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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23388404     EISSN : 26572311     DOI : https://doi.org/10.33508/jfst
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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year in March and October, containing research articles, review and short communication in the pharmacy science field, including medicinal chemistry, analytical chemistry, biological pharmacy, pharmaceutical sciences, and clinical pharmacy researches; the practice of pharmacy in industry, clinic and community, such as pharmacies, distributors and pharmacy education.
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Articles 172 Documents
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Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Annona squamosa L. Rofida, Siti; Firdiansyah, Ahmad; Fitriyastuti, Endah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.693

Abstract

Cause of cardiovascular disease risk factors, one of which is a high cholesterol levels in serum. Mortality caused by cardiovascular disease as 17.3 million people. Annona squamosa L. or commonly referred custard apple is a plant from family Annonaceae and have been used for insecticide, antitumor, antidiabetic, antioxidant, anti-inflammatory, and antihyperlipidemia. The leaves of Annona squamosa L. contains acetogenin, diterpene, flavonoids, lignin, hydroxyl ketones, and benzoquinazolin. The aims of this study is to determine the optimum dose to reduce levels of LDL on hyperlipidemic rats. In this study, hyperlipidemic rats were divided into 5 groups, negative control group (normal feed), positive control group (normal feed and simvastatin at a dose of 0.9 mg/KgBW), treatment group 1 (normal feed and ethanol extract leaves of Annona squamosa L. at a dose of 0.25 mg/gBB, treatment groups 2 (normal feed and ethanol extract leaf of Annona squamosa L. at a dose of 0.75 mg/gBB, treatment groups 3 (normal feed and ethanol extract leaf of Annona squamosa L. at a dose of 1 mg/gBB). The results of identification by thin-layer chromatography on ethanol extract leaf of Annona squamosa L indicates the presence of flavonoids. The results showed that the ethanol extract leaves of Annona squamosa Linn. On hyperlipidemia rats, can lower LDL cholesterol levels at doses of 0.25 mg/gram BB.
Efek Antihiperurikemia Ekstrak Air Kelopak Bunga Rosela (Hibiscus sabdariffa L.) pada Tikus Putih Wistar Jantan Wahyuningsih, Sri; Yulinah, Ellin; Sukrasno, .; N, Karina
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.694

Abstract

Antihyperuricemia effectivity had been studying of water extract roselle calyx (Hibiscus sabdariffa L.) in Wistar male rats used at 46.25 mg/kgBW, 92.5 mg/kgBW and 185 mg/kgBW by using uricostatic methods. In uricostatic method had used drug comparison alopurinol 9 mg/kgBW of an induced with potassium oxonate 250 mg/kgBW peritoneally and high purin diet which contained 10% seed of Gnetum gnemon administrations within 14 days. The test of uric acid content had observed on day 1, 7 and 14. The results showed in uricostatic method with alopurinol as drug comparison that water extract of roselle calyx at doses 46,25 mg/kgBW and 185 mg/ kgBW had capability decreased the level of uric acid (p
Perbandingan Kadar Likopen pada Manilkara zapota L., Gnetum gnemon L., Ipomoea batatas L., dan Momordica charantia L. dengan Menggunakan Campuran Solven n-Heksan, Aseton, dan Etanol R, Nur Syafaatur; R, Panji; W, Reka; M, Rika; NHS, Cikra
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.695

Abstract

Lycopene, a member of the carotenoid family of phytochemicals is a lipid soluble antioxidant that is synthesized by many plants and microorganisms but not by animals and human. Lycopene is a natural pigment that imparts red color totomato, guava, rosehip, watermelon, and pink grapefruit. Separation of lycopene from tomato fruit using conventional solvents can be carried out by liquid-liquid extraction method, using a mixture of n-hexane, acetone and ethanol as a solvent. Lycopene assay can be performed using a spectrophotometer method. Sapodilla fruit, leather melinjo, is ripe, and Cilembu sweet potato are some examples of plants that have a yellowish red pigment. This study aimed to investigate and compare the levels of lycopene contained in Cilembu sweet potato (Ipomoea batatas L.), fruit sapodilla (Manilkara zapota L.), bitter melon fruit (Momordica charantia L.), as well as fruit leather melinjo (Gnetum gnemon L.) using conventional solvent extraction method with a mixture of n-hexane, acetone, and ethanol. Data was analyzed by one-way ANOVA, followed by LSD test at 5% level test. The results showed that the concentration of lycopene in the fresh Cilembu sweet potatoes, fresh sapodilla fruit, fresh bitter melon fruit, and fresh fruit peel melinjo is 0.038 ± 0.003 mg/g, 0.085 ± 0.009 mg/g, 0.054 ±0.004 mg/g, 0.015±0.000 mg/g. Fresh sapodilla fruit has the highest lycopene content of 0.085 ±0.009 mg/g.
Pembibitan Tanaman Purwoceng (Pimpinella pruatjan Molk) dengan Abu Vulkanik Sudrajad, Heru; Suharto, .; Fauzi, .
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.696

Abstract

Purwoceng (Pimpinella pruatjan Molk) represents one of the plantation medicines of Indonesia, which its population was almost extinction (endangered). Purwoceng represent the original plant of Indonesia with the swampy forest limited so that need special effort to preserve. Purwoceng represents the endemic species which was growing in the mountain with the height of 1.800-3.500 m dpl in West Java (Pangrango Mountain), Central Java (Dieng plateau) and East Java. Purwoceng seeds represent the highly cost commodity, which is observed by a lot of jamu industry. Volcano dusty from Kelud mountain eruption on Thusday, 12 February 2014 diseminating widely and reach the region Yogyakarta, Central Java and West Java. The volcano dusty could give the fertility of land and plant. It became the good materials for media planting. This research was conducted in Medicinal Plant and Traditional Medicine Research and Development Centre with Complete Random Device Methods, by using the volcano dusty media of Kelud mountain with the treatment of giberelin 0 (control), 25, 50 and 75 ppm. The research showed that the purwoceng seed with the addition of giberelin 25 ppm gave the best result of growth, the average of total leaf was 6,7 pieces, the length of handle was 6,11 cm and the length of root was 11, 7 cm with the colour of leaf was yellow green at 3 month olds.
Pengaruh Jamu Anemia terhadap Fungsi Ginjal di Rumah Riset Jamu“Hortus Medicus” Tawangmangu Ardiyanto, Danang; Triyono, Agus; Nisa, Ulfatun
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.697

Abstract

The use of herbal medicine in the formal health care requires adequate scientific evidence especially on herbal safety data. The herb could be used for the treatment of anemia. The indicator for the safety of the herb was kidney function by measuring urea and creatinine. A clinical trial study with pre-post test designed was conducted at the Jamu Research Center "Hortus Medicus" Tawangmangu to assess renal function of patients treated anemic with herbal formula for anemia. A total of 35 subjects volunteered to follow this study received therapy with herbal formula for 1 month. Formula was a herbal infusion made up of 5 grams of red amaranth leaves (Amaranthus tricolor L.), 10 grams herbs of tapak liman (Elephantopus scaber L.) and 15 grams of temulawak rhizome (Curcuma xanthorrhiza), taken 3 times a day. Kidney function was observed by measuring the levels of urea and creatinine subjects at baseline (D-0) and at day 28 (D-28). The results of t-test between urea levels in D-0 and D-28, showed the value of p = 0.942 (> 0.05) and creatinine levels in D-0 and D-28, p-value = 0.935 (> 0.05), which means no significant difference. It can be concluded that herbal formula for anemia did not affect renal function.
Observasi Klinik Ramuan Jamu untuk Menurunkan Berat Badan Pamadyo(, Sunu; Novianto, Fajar; Mujahid, Rohmat
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.698

Abstract

The prevalence of overweight (obesity) has increased significantly in the world. During this decade, obesity will become a health problem. Even today, obesity is referred to as the New World Syndrome, where it is continuity increasing the number of events almost all over the world. Based on Riskesdas in 2010, the prevalence of adult obesity in Indonesia had reached 21.7%, significantly increasing if it was compared to the previous Riskesdas in 2007 which were 10.3%. Obesity in the younger people was associated with the increased of the incident risk of coronary heart disease, hypertension, hypercholesterolemia, diabetes mellitus and metabolic disorders. Obesity has a strong correlation with morbidity and mortality, and received serious attention on the causes, prevention and treatment efforts. Until now, there has been no specific drugs used for weight loss. People saw fitoterapi as a weight loss (besides diet)drug, because it has been considered relatively safe and without significant side effects. Jamu consisting of Jati Belanda, Kemuning, Kelembak and tempuyung was used in Saintifikasi Jamu Clinic. The results in this jamu showed that capsule weight loss has gave lower Body Mass Index (BMI) for 2 months but it has not lowered the BMI category of overweight to normal. The jamu could significantly reduce the weight of research subyek after administration for 28 days, with an average decline of 3.9 Kg and a highly significantly decrease after 56 days administration, with an average decrease of 6.7 Kg, compared to the initial weight. Medicinal herb could reduce the waist 41.1 cm, after 56 days administration. The herbs could not reduce the upper arm circumference, after 56 days administration.
Formulasi and Evaluasi Stabilitas Fisik Suspensi Ubi Cilembu (Ipomea batatas L.) dengan Suspending Agent CMC Na dan PGS Sebagai Antihiperkolesterol Fitriani, Yeyen Nor; INHS, Cikra; Yuliati, Ninis; Aryantini, Dyah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.699

Abstract

Drug which has small solubility in water is one of the problems that cause instability of pharmaceutical preparations. One drug practically insoluble in water is cilembu (Ipomoea batatas L.). So cilembu (Ipomoea batatas L.) made in form of suspension in order to produce stable preparations in liquid form. Making of the suspension cannot be separated from the suspending agent. CMC Na (Carboxymethylcellulose Sodium) and PGS (pulvis gummosus) is suspending agent which have been studied to produce a stable suspension. Accordingly, this study was conducted to know the suspension evaluation stability cilembu (Ipomoea batatas L.) with a suspending agent CMC Na and PGS as antihypercholesterol. Method of manufacture is dispersion method. Evaluation of physical stability test was conducted on the organoleptic, homogeneity, pH, density, viscosity, sedimentation volume, and redispersion. Data were analyzed with repeated measures and shelflife. Evaluation of physical stability the suspension cilembu with a suspending agent CMC Na and PGS on observations organoleptic, homogeneity, density and redispersion showed no difference, while the pH, viscosity and sedimentation volume were not significant differences (p< 0.05) during 30 days of storage.
Efek Farmakologi Infusa Biji Melinjo (Gnetum gnemon L.) Sebagai Antihiperglikemia pada Mencit (Mus musculus) yang Diinduksi Dextrosa Monohidrat 40% Feri Ira W(, Cita Dwi; NHS, Cikra Ikhda
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.700

Abstract

Diabetes mellitus is a group of disorders in which the body's carbohydrates, fats, and proteins metabolism was disordered and it has many other causes. This study objectives was to determine the pharmacological effects of melinjo infusion in decreasing blood glucose levels in mice (Mus musculus). This study using mice (Mus musculus) aged 2-3 months, 20 grams body weight. A total of 12 mice were divided into 4 groups, each was given dextrose monohydrate 40%. Group I as a negative control (CMC Na 1%), group II as positive control (glibenclamide), group III (melinjo infusion 25% w/v ) and group IV (melinjo infusion 50% w/v). The data obtained from the examination of blood glucose levels for 24 hours with an interval of 6 hours. Melinjo (Gnetum gnemon L.) infusion dose that can lower blood glucose levels in hyperglycemic mice is 50%. Repeated analysis of the data was done using ANOVA Duncan's test. The results showed that the dose 50% of infusion melinjo have a pharmacological effect in decreasing blood glucose levels by 33,41% and it was different significantly (p>0.01) compared to glibenclamide.
Efek Pemberian Fraksi Ekstral Etanol Daun Sirih (Piper betle L) pada Penurunan Nafsu Makan dan Berat Badan Tikus Wistar Jantan Mude, Serafin Anastasia; Tamayanti, Wahyu Dewi; Liben, Paulus
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.701

Abstract

Telah dilakukan penelitian mengenai elek pemberian Iraksi air ekstrak etanol pada daun sirih (Piper betle L.) pada penurunan nalsu makan dan berat badan pad a tikus Wistar. Pa~a penelitian ini tikus Wistar (Rattus norvegicus) jantan sebanyak 25 ekor dibagi dalam 5 kelompok, kelompok kontrol negatil K(-); 3 kelompok uji (Fl, F2, F3); dan kelompok kontrol positil (P). K(-) menerima perlakuan PGA 3% tanpa bahan aktil; Fl, F2, F3 masing-masing menerima Iraksi air ekstrak etanol daun sirih dengan dosis 300, 450, dan 600 mglkgBB; dan P menerima orlistat dengan dosis 10,B mglkgBB. Setiap perlakuan diberikan seeara oral selama 7 hari berturut-turut sekali sehari sebelum pengamatan. Jumlah sisa makanan dan berat badan (BB) ditimbang dan dieatat setiap hari. Hasil penelitian menunjukkan bahwa Fl, F2, dan F3 mampu menurunkan nalsu makan dan berat badan t ikus putih dibandingkan terhadap K(-). Selisih rerata penurunan jumlah makanan adalah 3,4 g (Fl); 3,8 g (F2); dan 4,2 g (F3). Penurunan tersebut setara dengan penurunan jumlah makanan kelompok P yaitu 4,2 g. Pada sisi BB, Fl; F2; dan F3 menunjukkan selisih rerata penurunan BB sebesar 14,6 g; 20,8 g dan 26,6 g. Selisih penurunan yang dihasilkan oleh F3 menunjukkan nilai mendekati penurunan berat badan oleh kelompok P yaitu 28,6 g. Penelitian ini mengindikasikan bahwa pemberian Iraksi air ekstrak etanol daun sirih (Piper betie L.) dalam dosis 300; 450; dan 600 mglkgBB seeara ora l mampu menurunkan jumlah makanan dan berat badan pada tikus Wistar jantan . Perhitungan koelisien korelasi menunjukkan tidak ada hubungan linear antara peningkatan dosis dengan peningkatan penurunan jumlah makanan dan berat badan tikus.
Efek Fraksi Air Daun Salam (Syzygium polyanthum) Terhadap Imunitas Alami Tikus Wistar Jantan Tamayanti, Wahyu Dewi; Soegianto, Lisa; Nurak, Elisabeth; Hadisoewignyo, Lannie; Ervina, Martha
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.702

Abstract

Pemberian fraksi air daun salam (Syzygium polyanthum) terhadap jumlah netrofil dan kadar IL-6 tjkus Wistarjantan yang telah diinduksi Staphylococcus aureus telah dilakukan. Tikus Wistar jantan dibagi dalam 3 ckelompok, masing-masing terdiri dari 5 ekor tikus, yaitu kelompok kontrol negatif (perlakuan NaCI 0,9%) kelompok uji (perlakuan fraksi air daun salam 200 mg/kg BB) dan ~elompok kontrol positif (perlakuan suspensi ibuprofen 400 mg/kg BB). Tikus dengan perlakuan dikorbankan satu jam setelah induksi Staphylococcus aureus, dan diambil darahnya. Perhitungan jumlah netrofil darah dilakukan .di bawah mikroskop dan penentuan kadar IL-6 dilakukan dengan metode ELISA. Hasil ana lisa data dengan anava satu arah mengindikasikan bahwa daun salam tidak menurunkan jumlah netrofil darah maupun IL-6 pada tikus Wistar jantan yang terinduksi Staphylococcus aureus.

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