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Journal of Advanced Pharmaceutical Research Sciences and Sustainability
Published by Yayasan Adra Karima Hubbi
ISSN : -     EISSN : 31107117     DOI : 10.70177/japrss
Core Subject : Health,
Medicine & Pharmacology
Journal of Advanced Pharmaceutical Research Sciences and Sustainability is an international peer-reviewed journal dedicated to interchange for the results of high-quality research in all aspect of Pharmacy, Medicinal Chemistry, Social Behavior, and Administrative Pharmacy. The journal publishes state-of-art papers in fundamental theory, experiments and simulation, as well as applications, with a systematic proposed method, sufficient review on previous works, expanded discussion and concise conclusion. As our commitment to the advancement of science and technology, the Journal of Advanced Pharmaceutical Research Sciences and Sustainability follows the open access policy that allows the published articles freely available online without any subscription.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Innovative Nanoparticle-Based Drug Delivery Systems for Targeted Cancer Therapy Folny, Anggia; Anbro, Rechny
Journal of Advanced Pharmaceutical Research Sciences and Sustainability (JAPRSS) Vol. 1 No. 1 (2025)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Background: Targeted cancer therapy aims to maximize therapeutic efficacy while minimizing adverse effects, a challenge often limited by non-specific drug distribution. Nanoparticle-based drug delivery systems have emerged as a promising solution, offering enhanced targeting capabilities and improved drug bioavailability. These innovative systems can deliver therapeutic agents directly to tumor cells, reducing systemic toxicity and improving patient outcomes. Objective: This study aims to evaluate the efficacy and safety of nanoparticle-based drug delivery systems in targeted cancer therapy. The research focuses on the development and testing of various nanoparticle formulations to enhance drug delivery to cancerous tissues while minimizing off-target effects. Methods: A comprehensive experimental approach was employed, including the synthesis of different nanoparticle formulations, in vitro and in vivo testing, and comparative analysis. Nanoparticles were engineered to encapsulate common chemotherapeutic agents and modified with targeting ligands to enhance specificity. In vitro cytotoxicity assays were conducted on multiple cancer cell lines, followed by in vivo studies on tumor-bearing mice to assess biodistribution, therapeutic efficacy, and toxicity. Results: The nanoparticle-based drug delivery systems demonstrated significantly improved targeting and retention in tumor tissues compared to conventional delivery methods. In vitro studies showed enhanced cytotoxicity in cancer cells, with minimal impact on healthy cells. In vivo studies revealed higher tumor accumulation of the drug-loaded nanoparticles, resulting in greater tumor reduction and fewer side effects. Comparative analysis indicated superior performance of targeted nanoparticles over non-targeted formulations. Conclusion: Nanoparticle-based drug delivery systems offer a promising approach for targeted cancer therapy, providing enhanced specificity, reduced systemic toxicity, and improved therapeutic outcomes. These findings support further development and clinical evaluation of nanoparticle formulations to optimize cancer treatment strategies.
3D Printing of Personalized Medications: Current Trends and Future Prospects Gerb, Unuel; Anggil, Birty
Journal of Advanced Pharmaceutical Research Sciences and Sustainability (JAPRSS) Vol. 1 No. 1 (2025)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Background: 3D printing technology, also known as additive manufacturing, has rapidly advanced and is now being explored for its potential in creating personalized medications. This innovative approach offers the possibility of producing customized dosage forms tailored to individual patient needs, addressing issues such as precise dosing, polypills, and patient compliance. Objective: The study aims to review the current trends in 3D printing of personalized medications, exploring its applications, technological advancements, regulatory challenges, and potential future directions. The focus is on understanding how this technology can revolutionize pharmaceutical manufacturing and patient care. Methods: A comprehensive literature review was conducted, analyzing academic articles, patents, and regulatory documents published between 2015 and 2023. The study examined various 3D printing techniques, such as fused deposition modeling (FDM), stereolithography (SLA), and selective laser sintering (SLS), and their applications in pharmaceutical production. Data were collected on the types of drugs being printed, the materials used, and the clinical outcomes associated with these personalized medications. Results: The review identified significant progress in the development of 3D-printed medications, with successful cases reported in creating customized dosages and multi-drug polypills. The technology has demonstrated the ability to produce medications with complex release profiles and unique shapes, enhancing patient adherence. However, regulatory hurdles and the need for extensive clinical validation remain major challenges. The study also highlighted emerging trends, such as the use of bioprinting for creating biologically active compounds and the integration of 3D printing with digital health technologies. Conclusion: 3D printing holds promising potential for revolutionizing the pharmaceutical industry by enabling the production of personalized medications. While significant advancements have been made, further research and regulatory developments are necessary to fully realize its benefits. The future of 3D-printed medications will likely involve a combination of technological innovations and new regulatory frameworks to ensure safety, efficacy, and accessibility.
Innovative Nanoparticle-Based Drug Delivery Systems for Targeted Cancer Therapy Edvy, Ronald; Areal, Jhino
Journal of Advanced Pharmaceutical Research Sciences and Sustainability (JAPRSS) Vol. 1 No. 1 (2025)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Background: Targeted cancer therapy aims to maximize therapeutic efficacy while minimizing adverse effects, a challenge often limited by non-specific drug distribution. Nanoparticle-based drug delivery systems have emerged as a promising solution, offering enhanced targeting capabilities and improved drug bioavailability. These innovative systems can deliver therapeutic agents directly to tumor cells, reducing systemic toxicity and improving patient outcomes. Objective: This study aims to evaluate the efficacy and safety of nanoparticle-based drug delivery systems in targeted cancer therapy. The research focuses on the development and testing of various nanoparticle formulations to enhance drug delivery to cancerous tissues while minimizing off-target effects. Methods: A comprehensive experimental approach was employed, including the synthesis of different nanoparticle formulations, in vitro and in vivo testing, and comparative analysis. Nanoparticles were engineered to encapsulate common chemotherapeutic agents and modified with targeting ligands to enhance specificity. In vitro cytotoxicity assays were conducted on multiple cancer cell lines, followed by in vivo studies on tumor-bearing mice to assess biodistribution, therapeutic efficacy, and toxicity. Results: The nanoparticle-based drug delivery systems demonstrated significantly improved targeting and retention in tumor tissues compared to conventional delivery methods. In vitro studies showed enhanced cytotoxicity in cancer cells, with minimal impact on healthy cells. In vivo studies revealed higher tumor accumulation of the drug-loaded nanoparticles, resulting in greater tumor reduction and fewer side effects. Comparative analysis indicated superior performance of targeted nanoparticles over non-targeted formulations. Conclusion: Nanoparticle-based drug delivery systems offer a promising approach for targeted cancer therapy, providing enhanced specificity, reduced systemic toxicity, and improved therapeutic outcomes. These findings support further development and clinical evaluation of nanoparticle formulations to optimize cancer treatment strategies.
Optimization of Liposome Formulations for Enhanced Bioavailability of Hydrophobic Drugs Adni, Merty; Ambi, Nerty
Journal of Advanced Pharmaceutical Research Sciences and Sustainability (JAPRSS) Vol. 1 No. 1 (2025)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Background: Hydrophobic drugs often face challenges in achieving sufficient bioavailability due to their poor solubility in aqueous environments. Liposomes, with their ability to encapsulate both hydrophilic and hydrophobic compounds, present a promising solution to enhance the bioavailability of these drugs. Optimization of liposome formulations is crucial to maximize their effectiveness in drug delivery. Objective: This study aims to optimize liposome formulations to enhance the bioavailability of hydrophobic drugs. The research focuses on identifying key formulation parameters that influence the encapsulation efficiency, stability, and release profiles of liposome-encapsulated hydrophobic drugs. Methods: Various liposome formulations were prepared using different lipid compositions, cholesterol content, and preparation methods. The hydrophobic drug was encapsulated in the liposomes, and the formulations were characterized for particle size, zeta potential, encapsulation efficiency, and drug release profiles. In vitro studies were conducted to evaluate the stability and release kinetics of the formulations. Additionally, in vivo studies in animal models were performed to assess the bioavailability and therapeutic efficacy of the optimized liposome formulations. Results: The optimized liposome formulation demonstrated a significant increase in encapsulation efficiency and stability compared to initial formulations. Particle size analysis revealed that smaller liposomes with a high cholesterol content exhibited improved stability and prolonged drug release. In vitro and in vivo studies confirmed that the optimized liposomes enhanced the bioavailability of the hydrophobic drug, resulting in higher plasma drug concentrations and improved therapeutic outcomes. Conclusion: Optimization of liposome formulations is essential for enhancing the bioavailability of hydrophobic drugs. The study identified critical formulation parameters that influence the performance of liposome-encapsulated drugs, providing valuable insights for future development. These findings support the potential of optimized liposome formulations to improve the delivery and efficacy of hydrophobic drugs.
Advances in Transdermal Drug Delivery Systems for Systemic Disease Management Laurn, Pheny; Arean, Much
Journal of Advanced Pharmaceutical Research Sciences and Sustainability (JAPRSS) Vol. 1 No. 1 (2025)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Background: Transdermal drug delivery systems (TDDS) have emerged as a promising alternative to conventional drug administration routes for systemic disease management. These systems offer several advantages, including improved patient compliance, steady drug release, and avoidance of gastrointestinal metabolism. Recent technological advancements have further enhanced the efficacy and applicability of TDDS, making them a viable option for a wide range of therapeutic applications. Objective: This study aims to review the recent advances in TDDS, focusing on new technologies, materials, and formulations that have improved drug delivery efficiency and patient outcomes in systemic disease management. Methods: A comprehensive literature review was conducted, covering scientific articles published between 2015 and 2023. The study examined various aspects of TDDS, including the types of drugs delivered, the materials used for transdermal patches, and the innovations in delivery mechanisms. Data was collected on the clinical efficacy, safety profiles, and patient adherence associated with these systems. Results: The review identified significant advancements in TDDS, such as the development of microneedles, iontophoresis, and ultrasound-enhanced delivery systems. These technologies have improved drug permeability through the skin, enabling the effective delivery of larger molecules and peptides. Additionally, new materials, such as bioadhesive polymers and hydrogel matrices, have enhanced the stability and comfort of transdermal patches. Clinical studies reported positive outcomes in patient adherence and therapeutic efficacy, particularly in managing chronic conditions like hypertension, diabetes, and pain. Conclusion: Recent advancements in TDDS have significantly broadened their therapeutic scope, making them an increasingly attractive option for systemic disease management. The integration of innovative technologies and materials has improved drug delivery efficiency and patient experience. Future research should focus on further optimizing these systems and expanding their applications to more complex therapeutic areas.

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