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MEDULA
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Fakultas Kedokteran Universitas Halu Oleo, Kampus Hijau Bumi Tridharma Andonuhu, Kendari 93232
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MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Published by Universitas Halu Oleo
ISSN : 23391006     EISSN : 24430218     DOI : https://doi.org/10.46496
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
MEDULA invites contributions to original and fundamental research in the field of health, which must be submitted for peer reviewed articles. The journals focus and scope are contemporary medicine through biomedical research, genetics, and medical technology, Patient care practices, Disease prevention, Disease epidemiology, Family medicine, Health care center management, New drug development through research on the effectiveness of medicinal plants in treating disease, Development of traditional medicines frequently used by local communities, Utilization of marine biota for medicinal purposes, Social aspects related to the implementation of medical education and other relevant fields
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol. 11 No. 2 (2024)" : 5 Documents clear
The Effect Of Isometric Handgrip Exercise In Reducing Blood Pressure Of Hypertension Patients In Bajoe Village, Soropia Subdistrict, Konawe Regency Wikal Sulistia Dwi Putra; Amiruddin Eso; Pranita Aritrina Syafri; Yenti Purnamasari
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.35

Abstract

ABSTRACT Background. Hypertension is a condition where systolic blood pressure is ≥140 mmHg and diastolic pressure is ≥90 mmHg at rest. Isometric handgrip exercise is one type of exercise that is effective in reducing blood pressure in patients with hypertension. The purpose of this study was to determine the effect of isometric handgrip exercise in reducing blood pressure in hypertensive patients in Bajoe Village, Soropia Subdistrict, Konawe Regency. Methods. This study used a pre-experiment research design with a one group pretest posttest design approach with the independent variable being isometric handgrip exercise and the dependent variable being blood pressure. The sample in the study was the community of Bajoe Village, Soropia Subdistrict, Konawe Regency who suffered from hypertension as many as 30 people who were taken using Purposive Sampling technique and data analysis using Paired sample t test. Data obtained from blood pressure measurements measured before and after doing isometric handgrip exercise for 5 minutes in 5 consecutive days. Results. The results obtained from 30 samples showed that isometric handgrip exercise intervention reduced mean systolic blood pressure by 7.35 mmHg (p = 0.000) and mean diastolic blood pressure by 2.53 mmHg (p = 0.000). Conclusion. There is an effect of isometric handgrip exercise in reducing blood pressure of hypertensive patients in Bajoe Village, Soropia Subdistrict, Konawe Regency.
Anti-inflammatory Activity of Kappaphycus Alvarezii Using Protein Denaturation Inhibition Method Windy Zafa Amalia; Sulastrianah; Arimaswati
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.37

Abstract

ABSTRACT Background: Inflammation is the body's reaction to injury or tissue damage. As an NSAID, diclofenac sodium is frequently used. But since this medication has adverse effects, a substitute is required. Flavonoids found in K. alvarezii may have therapeutic uses and anti-inflammatory potential. Purpose: The goal of this research was to investigate the anti-inflammatory effect of K. alvarezii utilizing the protein denaturation inhibition method. Method: The IC50 was utilized to test anti-inflammatory effect through protein denaturation inhibition. Diclofenac sodium served as a positive control. The data were then analyzed with an independent t-test. Result: The anti-inflammatory activity test produced an IC50 of 197.94 ppm for extract K. alvarezii and 35.7 ppm for diclofenac sodium. The statistical test found a significant difference between seaweed ethanol extract K. alvarezii and sodium diclofenac (p = 0.000). Keywords: anti-inflammatory; Kappaphycus alvarezii; protein denaturation inhibition.
The Antibacterial Activity of Arabian Bidara Leave (Ziziphus spina-christi L.) against the growth of Escherichia coli Sufiah Asri Mulyawati; Amiruddin Eso; Yusni Nurul Hidayah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.38

Abstract

ABSTRACT Background: The primary cause of mortality for children, according to the World Health Organization, is infectious illnesses. Escherichia coli is one of the bacteria that may infect people. Infections caused by E. coli have historically been treated with antibiotics. Antibiotic resistance, however, can result from improper usage. Arabian Bidara is a plant that has been shown to possess antibacterial qualities, making it a viable alternative therapy. The antibacterial properties of this plant's leaves effectively combat a variety of dangerous germs and pathogens. Purposes: to determine the effectiveness of the ethanolic extract of bidara arabic leaves as an antibacterial against the growth of Escherichia coli bacteria. Methods: This research are an experimental study with a post test only control group design with the independent variable being the treatment of arabic bidara leaf extract, the dependent variable being the zone of inhibition against Escherichia coli . Positive control in the form of ciprofloxacin and negative control using distilled water. The concentrations used were 1500 ppm, 2000 ppm, 2500 ppm and 3000 ppm with three repetitions. Results: This study showed that the ethanolic extract of bidara arabic leaves could inhibit the growth of Escherichia coli bacteria with a strong zone of inhibition at concentrations of 2000 ppm, 2500 ppm, and 3000 ppm and an inhibition zone category classified as weak at a concentration of 1500 ppm. Conclusion: There is antibacterial effectiveness of the ethanolic extract of the leaves of the arabic bidara (Ziziphus spina-christi L.) against the growth of Escherichia coli bacteria. Keywords: Antibacterial; Escherichia coli ; Ziziphus spina-christi L
VAS Pain Analysis Before and After Genicular Nerve Block in Different Types Occupations of Knee Osteoarthritis Patients in Orthopedic Polyclinic Hati Mulia General Hospital Kendari Febriski Okta Bimantara S; Muhammad Rustam HN; Tien
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.39

Abstract

ABSTRACT Background: Knee OA patients suffer from joint pain, stiffness, instability, and swelling. This causes a decrease in the quality of life and daily activities. Knee osteoarthritis is a multifactorial disease, namely modifiable and non-modifiable factors. One of the modifiable risk factors for OA is occupation. One of the therapies for knee OA is Genicular Nerve Block (GNB). Purposes: to determine the correlation between the type of work and VAS of pain before and after genicular nerve block in knee OA patients at the Orthopedic Clinic, Hati Mulia General Hospital, Kendari. Methods: This quasi-experimental research used a one-group pretest-posttest design approach without control. This study has conducted using a questionnaire (informed consent, respondent form, and VAS sheet) from 29 OA patients before and after genicular nerve block (GNB) was performed at the orthopedic polyclinic of Hati Mulia General Hospital for the period November 2021. The dependent variable observed was VAS and the independent variable observed was the type of work. Data analysis used the Spearmen and Wilcoxon statistical test and if p <0.05, it indicated that there was a correlation between the independent and dependent variables. Results: Analysis of the correlation between occupational type and VAS pain before genicular nerve block (GNB) obtained p-value = 0.624, the correlation between occupational type and VAS pain after GNB obtained p-value = 0.716, and the influence before and after GNB on VAS pain obtained p-value = 0.000. Conclusion: There was no correlation between the occupational type and the pain VAS before and after Genicular nerve block (GNB) there was a difference before and after the Genicular nerve block (GNB) on the pain VAS. Keywords: Osteoarthritis, ocupational type, VAS, GNB
Effectivity Test of Ethanol Extract of Arabic Bidara Leaf (Ziziphus Spina-Christi L.) As Antibacterially Against Growt Bacteria Pseudomonas aeruginosa and Bacillus cereus Vira Adiningsi; Amiruddin Eso; Yenti Purnamasari
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.40

Abstract

Background. Infection disease is one of the major health problems in developing countries including Indonesia, one of which is nosocomial infection caused by Pseudomonas aeruginosa bacteria. On the other hand, food poisoning is still a serious problem in Indonesia especially caused by pathogenic bacteria, one of which is Bacillus cereus bacteria. Indonesia is famous for its potential as home to medicinal plants. One plant that can potentially be used as an alternative in the treatment of this bacterial infection is arabic bidara leaves. This study aims to find out the effectiveness of arabic bidara leaf ethanol extract (Ziziphus spina-christi L.) as antibacterial against bacterial growth of Pseudomonas aeruginosa and Bacillus cereus. Methods. This study was an experimental study with a post test only control group design with a free variable in the form of treatment of arabic bidara leaf extract, a bound variable in the form of an inhibitory zone against Pseudomonas aeruginosa and Bacillus cereus. Positive control of ciprofloxacin and negative control using aquades. The concentrations used were 1500 ppm, 2000 ppm, 2500 ppm and 3000 ppm with three repetitions. Results. An ethanol extract of arabic bidara leaves has an inhibitory zone classified as strong at concentrations of 2000 ppm, 2500 ppm, and 3000 ppm. Conclusion. There is an antibacterial effectiveness of arabic bidara leaf ethanol extract against bacterial growth of Pseudomonas aeruginosa and Bacillus cereus. Keywords: Antibacterial, Bidara Arab Leaves, Pseudomonas aeruginosa, Bacillus cereus

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