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Indonesian Journal of Herbal and Biomedical Research
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INDONESIA
Indonesian Journal of Herbal and Biomedical Research
Published by Bahiraliya Natura Science
ISSN : 31245447     EISSN : 31245447     DOI : https://doi.org/10.66982/ijhbr.v1i1
Core Subject :
The Indonesian Journal of Herbal and Biomedical Research (IJHBR) is a peer-reviewed, double-blind, open-access scientific journal published and managed by Bahiraliya Natura Science (E-ISSN: 3124-5447), a scientific organization affiliated with Politeknik ‘Aisyiyah Pontianak, committed to advancing research in herbal medicine, natural products, and biomedical sciences in Indonesia and internationally. The IJHBR serves as a platform for researchers, academics, and practitioners to share scientific findings, innovations, and insights related to herbal therapy, pharmacognosy, phytochemistry, molecular biology, clinical applications, and health science. The journal welcomes original research articles, review papers, and short communications that contribute to the growing body of knowledge on herbal and biomedical research. IJHBR published periodically (twice a year) in June and December. Every article that goes to the editorial staff will be selected through Desk Review and Initial Manuscript Evaluation processes by Editorial Board. Then, the articles will be sent to the Mitra Bebestari/peer reviewer and will go to the next selection by Double-Blind Peer-Review Process.
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Articles 5 Documents
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Search results for , issue "vol. 2 no. 1 (2026)" : 5 Documents clear
Analisis In Silico Potensi Aktivitas Biologis Senyawa Volatil Asap Cair Tempurung Kelapa Muhammad Andre Reynaldi; Rafika Sari; Abdurraafi’ Maududi Dermawan; Enggy Erwansani; Shahiroh Haulaini; Aulia Faradilla
Indonesian Journal of Herbal and Biomedical Research Vol. 2 No. 1 (2026)
Publisher : Bahiraliya Natura Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66982/ijhbr.v2i1.6

Abstract

Coconut shell liquid smoke contains various volatile compounds with potential biological activities that can be explored through computational approaches. This study aimed to predict the potential biological activities of volatile compounds identified in coconut shell liquid smoke using the PASS Online platform as an initial computational screening approach to identify promising natural bioactive compounds for further pharmacological investigation and drug discovery. Five representative volatile compounds reported in previous studies, namely 2-hydroxymethylphenol, 3-methoxybenzene-1,2-diol, 2-methoxyphenol, 2,6-dimethoxyphenol, and 4-methyl-1,2-benzenediol, were selected for analysis. Prediction of biological activities was performed using PASS Online based on the probability of activity (Pa) and probability of inactivity (Pi) values. The results showed that all compounds exhibited high potential biological activities with Pa values above 0.900. The dominant predicted activities included aspulvinone dimethylallyltransferase inhibitor, feruloyl esterase inhibitor, JAK2 expression inhibitor, membrane integrity agonist, and ubiquinol-cytochrome-c reductase inhibitor. Several compounds also demonstrated potential activities related to anti-inflammatory and antimicrobial mechanisms. The predicted activity profiles suggest that volatile phenolic compounds in coconut shell liquid smoke may represent promising candidates for further bioactivity exploration. However, these computational predictions require experimental validation through in vitro and in vivo studies before their biological potential can be confirmed.
Artikel Review : Sistem Penghantaran Obat Berbasis pH Tertarget pada Kolon: Tinjauan Mekanisme dan Efektivitas Formulasi Enterik Nobel Pangarintungan
Indonesian Journal of Herbal and Biomedical Research Vol. 2 No. 1 (2026)
Publisher : Bahiraliya Natura Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66982/ijhbr.v2i1.7

Abstract

pH-responsive drug delivery systems have emerged as a promising strategy to achieve targeted drug release in the colon by protecting drugs from premature release in the upper gastrointestinal tract. This review aimed to evaluate recent advances in pH-responsive colon-targeted drug delivery systems published between 2016 and 2025. A Systematic Literature Review (SLR) was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Literature was retrieved from PubMed, ScienceDirect, and SpringerLink using predefined keywords. After applying the inclusion and exclusion criteria, ten original research articles were included for qualitative synthesis. The findings demonstrated that pH-responsive nanoparticles, microparticles, and polymer-coated beads consistently minimized drug release under acidic conditions while enhancing drug release at colonic pH. Eudragit-based polymers, either alone or combined with natural polymers and advanced carrier materials, remained the most widely used formulations because of their favorable drug protection, encapsulation efficiency, controlled release, and therapeutic performance. Recent developments indicate a shift toward multifunctional and multi-responsive delivery platforms to improve colon-specific drug delivery. However, most available evidence is limited to preclinical studies, highlighting the need for further clinical investigations to facilitate future therapeutic applications.
Perbedaan Sensitifitas Air Rebusan Daun Sirih Hijau dengan Daun Sirih Merah dalam Menghambat Pertumbuhan Bakteri Escherichia coli Menggunakan Metode Difusi Kamarudin Kamarudin; Suwandi Edy
Indonesian Journal of Herbal and Biomedical Research Vol. 2 No. 1 (2026)
Publisher : Bahiraliya Natura Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66982/ijhbr.v2i1.8

Abstract

Green betel leaves contain essential oils, tannins, alkaloids, flavonoids, phenols, and steroids. Conversely, red betel leaves contain chemical compounds such as flavonoids, alkaloids, tannins, and essential oils. The compounds present in red betel leaves are secondary metabolites that can be utilized as medicinal agents. This study aimed to evaluate the differences in the antibacterial efficacy of green and red betel leaf decoctions in inhibiting the growth of Escherichia coli using the diffusion method. A comparative research design was employed to determine the magnitude of the differences between the observed groups. The results demonstrated that across 16 samples of green betel leaf decoction, the zone of inhibition ranged from 9 mm to 11 mm, with a mean of 10 mm. In contrast, the 16 samples of red betel leaf decoction exhibited a minimum inhibition zone of 11 mm and a maximum of 13 mm, with a mean inhibition zone of 11.88 mm (~12 mm). The Mann-Whitney U test yielded a p-value of 0.000 (p < 0.05), indicating a statistically significant difference in inhibitory activity between green and red betel leaf decoctions against the growth of Escherichia coli.
Perbedaan Daya Hambat Ekstrak Etanol Daun Miana Merah Konsentrasi 10%, 20% Dan 30% Terhadap Pertumbuhan Bakteri Shigella dysentriae Muhammad Yumni; Suwandi Edy
Indonesian Journal of Herbal and Biomedical Research Vol. 2 No. 1 (2026)
Publisher : Bahiraliya Natura Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66982/ijhbr.v2i1.9

Abstract

The Miana plant is an easily cultivated ornamental species. In West Kalimantan, Miana grows abundantly in the wild and grows rapidly. Miana leaves contain bioactive compounds, including flavonoids, tannins, triterpenoids, and steroids, which serve as antibacterial agents. These phytochemicals can inhibit bacterial growth, particularly that of Shigella species. This study aimed to elucidate the differences in the inhibitory efficacy of various concentrations of Miana leaf ethanol extract on the growth of Shigella dysenteriae. A quasi-experimental research design was employed. The study used Miana leaf ethanol extract samples at three treatment concentrations (10%, 20%, and 30%), with 10 replications per concentration. The inhibitory activity against S. dysenteriae was evaluated using the Kirby-Bauer disk diffusion method. Laboratory results revealed that the mean zones of inhibition formed at concentrations of 10%, 20%, and 30% were 7.90 mm, 9.10 mm, and 11.10 mm, respectively. Statistical analysis using the Friedman test yielded a p-value of 0.000 (p < 0.05). Consequently, there is a significant difference in the antibacterial inhibitory activity of red Miana leaf ethanol extracts at 10%, 20%, and 30% concentrations against the growth of Shigella dysenteriae.
Analisis Antibakteri Teh Kombucha Terhadap Bakteri Staphylococcus aureus Isolat Pus Ulkus Diabetikum Rosyiid Amrijuldin; Tilawaty Aprina; Khoirul Rista Abidin; Khairul Bariyah
Indonesian Journal of Herbal and Biomedical Research Vol. 2 No. 1 (2026)
Publisher : Bahiraliya Natura Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66982/ijhbr.v2i1.10

Abstract

Background: Diabetic ulcers are a chronic complication of diabetes mellitus that are frequently infected by Staphylococcus aureus. The increasing prevalence of antibiotic resistance has encouraged the search for natural antibacterial alternatives, one of which is green tea kombucha, which contains bioactive compounds produced during the fermentation process. Methods: This experimental study employed the disk diffusion method on Mueller–Hinton Agar (MHA). The samples consisted of green tea kombucha fermented for 7 days at concentrations of 20%, 30%, 40%, and 50%. Nebacetin was used as the positive control, while sterile distilled water served as the negative control. Bacterial isolates were identified using Mannitol Salt Agar (MSA). Statistical analysis was performed using the Mann–Whitney test to determine significant differences among the treatment groups. Results: Diabetic ulcer pus isolates exhibited the characteristic features of S. aureus, as indicated by the yellow color change of the culture medium. The antibacterial activity assay demonstrated that all kombucha concentrations inhibited the growth of S. aureus, with the largest inhibition zone observed at the 50% concentration (5.58 mm) and the smallest at the 40% concentration (4.30 mm). The Mann–Whitney test revealed a significant difference between the kombucha treatment groups and the negative control (p < 0.05). Conclusion: Green tea kombucha fermented for 7 days exhibited antibacterial activity against Staphylococcus aureus isolated from diabetic ulcer pus and shows potential as a natural antibacterial agent to support the treatment of wound infections in patients with diabetes.

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