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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 16 Documents
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Search results for , issue "Vol 29, No 01 (1997)" : 16 Documents clear
The impact of nosocomial postoperative wound infection on the cost of hospitalization in Obstetric and Gynecologic Unit, Sleman General Hospital,1992/1993 Stephani M, Stephani M
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.987 KB)

Abstract

Nosocomial postoperative wound infection is a combined clinical and managerial problem. This report discusses the impact of nosocomial postoperative wound infection on the cost of hospitalization, in the Obstetric and Gynecologic unit, Sleman General Hospital in 1992/1993. There are two methods of nosocomial postoperative wound infection examination used in this study, namely: (1) comparative analysis among infected with uninfected and (2) subjective comparison study. The result of the first method showed a total cost increase of Rp. 74,877.00 and subjective comparison yielded total cost increase of Rp. 3,112,371.80. Based on the diagnosis, the additional cost of nosocomial infection is as follows: (1) for Cephalopelvic Disproportion; Rp. 224,081.61; (2) for twin pregnancy, premature rupture of membranes, and prolonged pregnancy; Rp 290,457.09; (3) for uterine myoma (30 hospital days), the additional cost of nosocomial infection is Rp 513,564.66; (4) for premature rupture of membrane, and fetal distress, Rp. 75,793.87; (5) for malignant neoplasm of ovary; Rp. 328,838.70; (6) for malignant neoplasm of uterine cervix, Rp. 374,326.44; (7) for premature rupture of membranes, prolonged first stage and failure of vacuum extraction, the additional cost of nosocomial infection is Rp. 251,563.22; (8) for premature rupture of membranes, failure of induction of labor by medical methods and fetal distress, Rp. 177,619.35; (9) for uterine myoma (12 hospital days), 876,126.86. It is recommended, therefore, that nosocomial infection control committee should be established in Sleman General Hospital. The Committee will assist the hospital director in planning, implementing, monitoring and evaluating nosocomial infection control activities. A social marketing program to improve aseptic techniques, the use of appropriate antiseptic and the maintenance of sterility in the operating room should be implemented so that nosocomial infection can be prevented and may reduce the cost of hospital care.Key words: nosocomial infection - post operative wound infection - cost of treatment - comparative analysis - subjective comparison
Sensitivity and specificity of patch test in nickle allergic contact dermatitis I Ketut Darya Artana, I Ketut Darya Artana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Objectives of the study are as follows: first to compare the sensitivity and specificity of 5.0% nickle sulfate (NS) prepared by Pharmacy Unit Dr. Sardjito General Hospital and 5% NS International standard, and the second is to determine the ideal concentration of NS that can produce equal sensitivity and specificity with 5% NS International standard. Total number of sample is 86 subjects that have been recruited from Dermatology Clinic Sardjito General Hospital. Forty one patients with nickle allergic contact dermatitis and 45 patients with other dermatitis or healthy volunteers participated in the study. Every subject was tested with 5% NS International standard and 5.5%, 5.0%, 4.5%, 4.0%, 3.5%, 3.0%, 2.5%, 2.0% NS made by Pharmacy Unit Dr. Sardjito General Hospital. Result of the study shows that the sensitivity and specificity of 5% NS International standard are 95.12% and 95.56% respectively, while 5.0% NS made by Pharmacy Unit Sardjito General Hospital are 92.68% and 100% respectively (this differences is not statistically significant). Among different concentration of nickle sulfate made by Pharmacy Unit, 2.5% NS is the optimal concentration that can produce sensitivity and specificity which are equal to 5% NS International standard, both on the first and the second assessments (p = 0,06). Conclusion: 2.5% NS patch test made by Pharmacy Unit, Dr. Sardjito General Hospital can be used as standard material patch test for allergic contact dermatitis caused by nickel.Key word: nickle sulfate - pacth test - nickle allergic contact dermatitis.
Perinatal mortality in breech deliveries at Dr. Said%ito General Hospital, Yogyakarta Sulchan Sofoewan, Sulchan Sofoewan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Breech delivery is still of importance to discuss, because perinatal morbidity and mortility are higher than those vertex deliveries. A retrospective study was carried out on 141 cases of breech deliveries in Dr. Sardjito General Hospital during 1989 - 1990. The highest perinatal mortality was due to low birth weight: 17 cases (12%) compared to all cases (4.2%). No perinatal mortality of multiparity cases was found compared with cases of nulliparity i.e. 13 cases (17.0%). The type of breech presentation were frank breech: 85 cases (60.3%); incomplete: 21 cases (14.9%) and complete: 35 cases (24.8%). The highest perinatal mortality was frank breech presentation: 15 cases (17.6%). According to the termination of delivery, breech extraction has the highest perinatal mortality (23.%).Key Words: breech presentation - parity - perinatal - morbidity - mortality
The basal membrane destruction in benign prostatic hyperplasia, prostatic intraepithelial neoplasma, and prostatic adenocarcinoma. A study on basal membrane type IV collagens Irianiwati, Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Basal membrane (BM), a selective permeable membrane is mainly composed of type IV collagen. A tumor invasion, therefore, may only occur if this membrane is destroyed by an active process of tumor producing proteolytic enzymes. It has been found that prostatic intraepithelial neoplasia (PIN) is a prostatic premalignant lesion. Although both benign prostate hyperplasia (BPH) and prostatic adenocarcinoma required an androgenic hormone for their growth, the correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinoma should be clarified. This can be studied by observing the continuity of periacinair BM. In order to understand the correlation among prostatic lesions, the BM continuity of 40 paraffin block specimens (15 BPH, 11 PIN, and 14 Prostatic adenocarcinomas) were studied. The BM of these specimens were stained immunohistochemically with MoAB anti human Type IV collagens. The periacinair BM continuity was scored 0-5. The Spearmans correlation test was used to analyze their possible relationship.The result shows that there is a significant correlation between the degree of destruction of basal membranes and BPH, PIN, and Prostatic adenocarcinomas (r = 0.898; p<0.05). In conclusion, based on periacinair BM des-truction, there is a positive correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinomas.Key words : collagen type IV - prostatic adenocarsinoma - prostatic intrapithelial neoplasia - benign prostate hyperplasia - basal membrane
Comparison between vitamin E plasma level in diabetic retinopathy and normal person Tri Wahyu Widayanti, Tri Wahyu Widayanti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Diabetic retinopathy is one of the late complications of diabetes mellitus. Recent data have suggested that free radicals possibly play a role in its pathophysiology. Oxidative stress is very high in hyperglycemic condition leading to increased lipid peroxidation of the phospholipid cell membrane. Vitamin E is a chain breaking membrane antioxidant which can prevent lipid peroxidation in the cell membrane. The study was aimed at determining vitamin E plasma level in diabetic retinopathy compared to healthy subjects. In this study vitamin E plasma level in 30 diabetic retinopathy patients and 30 healthy subjects were measured by using (HPLC) technique. The result showed that the mean of vitamin E plasma level in healthy subjects and patients with diabetic retinopathy are 5.09 ± 3.51 and 4.32 ± 2.75 µg/ml respectively (Student t-test, p > 0.05) Total lipid level has a significant influence in increasing the vitamin E plasma level with coefficient correlation r=0.9746 and p<0.01. Further studies are needed to clasify factors that influence vitamin E plasma levels.Keywords: vitamin E - diabetic retinopathy - oxidative stress - lipid peroxidation
Accuracy of standard test of renal function status IKA-1984 Lydia Kosnadi, Lydia Kosnadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Measurements of standard inulin clearance and endogeous creatinine clearances were performed simultaneously in 112 children aged 2-14 years suffering from renal diseases. To diagnose the status of these renal functions, normal or decreased, a standard renal function test, namely IKA-1984, was used. The aim of this study was to investigate the accuracy of IKA-1984 compared with the other four standard renal function tests (i.e. Schwartz-1976, Feld-1990, Barratt-1975 and Chantler-1976). The data analysis used was clinical agreement in the interpretation of diagnostic tests. The results revealed very high kappa indexes (>0,80), providing IKA-1984 was accurate.Key words : inulin and creatinine clearances - renal function tests - accuracy - clinical disagreement - kappa index
Gadjah Mada stroke algorithm. Clinical strategy for distinguishing intracerebral haemorrhage from acute ischemic or infarction stroke Rusdi Lamsudin, Rusdi Lamsudin
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A Gadjah Mada Stroke Algorithm (GMSA) as a clinical strategy to distinguish intracerebral haemorrhage from acute ischaemic or infarction stroke after the onset of stroke has been developed and validated (internal validity) in 229 stroke patients. An observational-prospective study design was conducted to validate GMSA (external validity) from 350 acute stroke patients in Dr. Sardjito Hospital, Yogyakarta from 1st December 1992 to 30th June 1996. The scope of the study are as follows: (1) validity of multiple-parallel test against CT-Scan to define intracerebral haemorrhagic stroke diagnosis, (2) significance of correlation between 8 group-variables of GMSA and intracerebral haemorrhagic stroke diagnosis, and (3) the validity of every group-variable to define intracerebral haemorrhagic stroke. This study showed that the GMSA as a clinical strategy have a high validity (external validity) to distinguish intracerebral haemorrhagic stroke from acute ischaemic or infarction stroke.Key words : Gadjah Mada stroke algorithm - diagnostic test - intracerebral haemorrhagic stroke -acute ischaemic stroke - infarction stroke
The Relation between Epstein-Barr Virus and Hodgkins Disease: lmmuno-histo- pathological Analysis of EBV LMP-1 expression) C. Murtono, C. Murtono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

EBV-LMP-1 is one of the proteins formed in the B lymphocytes and that has an oncogenic property and expressed by Sternberg Reeds cells. Detection of EBV LMP-1 is a reliable method to determine the presence of EBV in Hodgkins disease. There were geographical distributions of Hodgkins disease based on its histological classification. This study determined the correlation between EBV and Hodgkins disease based on its histological subtype in Yogyakarta. Eighteen formaldehyde fixed in paraffin wax embedded specimen of Hodgkins disease were investigated for their EBV-LMP-1 expression by immunohistochemistry reaction with cocktail CS 1-4 (DAKO) as monoclonal antibody and Mayers Hematoxillin as counterstain. For negative control LMP-1 monoclonal antibody was omitted. EBV LMP-1 expression was detected in 9/18 (50%) of Hodgkins disease cases. The frequency of Hodgkins disease subtypes is as follows LP (lymphocytic predominance) 11.11%, NS (nodular sclerosis) 11.11%, MC (mixed cellularity) 22.22% and LD (lymphocytic depletion) 55.55%. The median age of the patients is 52.5 years with mean 52.3 year and SD 9.15 year. LMP-1 positivity was detected in 0/2 (0%) for LP subtype, 1/2 (50%) for NS, 2/4 (50%) for MC, and 6/10 for LD (60%). Based on EBV LMP-1 expression in the Sternberg Reed cells, it corroborated a significant role for EBV on the oncogenesis of Hodgkins disease in Yogyakarta especially for LD subtypeKey Words : Hodgkins disease - histological classification - latent membrane protein-1 (LMP-1) -immunohistochemistry - oncogenesis.
The Relation between Epstein-Barr Virus and Hodgkin's Disease: lmmuno-histo- pathological Analysis of EBV LMP-1 expression) C. Murtono C. Murtono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.948 KB)

Abstract

EBV-LMP-1 is one of the proteins formed in the B lymphocytes and that has an oncogenic property and expressed by Sternberg Reeds cells. Detection of EBV LMP-1 is a reliable method to determine the presence of EBV in Hodgkin's disease. There were geographical distributions of Hodgkin's disease based on its histological classification. This study determined the correlation between EBV and Hodgkin's disease based on its histological subtype in Yogyakarta. Eighteen formaldehyde fixed in paraffin wax embedded specimen of Hodgkin's disease were investigated for their EBV-LMP-1 expression by immunohistochemistry reaction with cocktail CS 1-4 (DAKO) as monoclonal antibody and Mayer's Hematoxillin as counterstain. For negative control LMP-1 monoclonal antibody was omitted. EBV LMP-1 expression was detected in 9/18 (50%) of Hodgkin's disease cases. The frequency of Hodgkin's disease subtypes is as follows LP (lymphocytic predominance) 11.11%, NS (nodular sclerosis) 11.11%, MC (mixed cellularity) 22.22% and LD (lymphocytic depletion) 55.55%. The median age of the patients is 52.5 years with mean 52.3 year and SD 9.15 year. LMP-1 positivity was detected in 0/2 (0%) for LP subtype, 1/2 (50%) for NS, 2/4 (50%) for MC, and 6/10 for LD (60%). Based on EBV LMP-1 expression in the Sternberg Reed cells, it corroborated a significant role for EBV on the oncogenesis of Hodgkin's disease in Yogyakarta especially for LD subtypeKey Words : Hodgkin's disease - histological classification - latent membrane protein-1 (LMP-1) -immunohistochemistry - oncogenesis.
The impact of nosocomial postoperative wound infection on the cost of hospitalization in Obstetric and Gynecologic Unit, Sleman General Hospital,1992/1993 Stephani M Stephani M
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.987 KB)

Abstract

Nosocomial postoperative wound infection is a combined clinical and managerial problem. This report discusses the impact of nosocomial postoperative wound infection on the cost of hospitalization, in the Obstetric and Gynecologic unit, Sleman General Hospital in 1992/1993. There are two methods of nosocomial postoperative wound infection examination used in this study, namely: (1) comparative analysis among infected with uninfected and (2) subjective comparison study. The result of the first method showed a total cost increase of Rp. 74,877.00 and subjective comparison yielded total cost increase of Rp. 3,112,371.80. Based on the diagnosis, the additional cost of nosocomial infection is as follows: (1) for Cephalopelvic Disproportion; Rp. 224,081.61; (2) for twin pregnancy, premature rupture of membranes, and prolonged pregnancy; Rp 290,457.09; (3) for uterine myoma (30 hospital days), the additional cost of nosocomial infection is Rp 513,564.66; (4) for premature rupture of membrane, and fetal distress, Rp. 75,793.87; (5) for malignant neoplasm of ovary; Rp. 328,838.70; (6) for malignant neoplasm of uterine cervix, Rp. 374,326.44; (7) for premature rupture of membranes, prolonged first stage and failure of vacuum extraction, the additional cost of nosocomial infection is Rp. 251,563.22; (8) for premature rupture of membranes, failure of induction of labor by medical methods and fetal distress, Rp. 177,619.35; (9) for uterine myoma (12 hospital days), 876,126.86. It is recommended, therefore, that nosocomial infection control committee should be established in Sleman General Hospital. The Committee will assist the hospital director in planning, implementing, monitoring and evaluating nosocomial infection control activities. A social marketing program to improve aseptic techniques, the use of appropriate antiseptic and the maintenance of sterility in the operating room should be implemented so that nosocomial infection can be prevented and may reduce the cost of hospital care.Key words: nosocomial infection - post operative wound infection - cost of treatment - comparative analysis - subjective comparison

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