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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Published by Universitas Gadjah Mada

ISSN : 01261312 EISSN : 23563931 DOI : http://dx.doi.org/10.19106/JMedSci005303202101

Core Subject : Science,

Immunology & microbiology Neuroscience

Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 16 Documents

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Search results for , issue "Vol 34, No 01 (2002)" : 16 Documents clear

Usage of propranolol to attenuate catabolism process in burn victim : A case report Ishandono Dahlan, Ishandono Dahlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.774 KB)

Burn is still a common injury faced by the surgeons. The mortality is considerably high. One of the improvement in the mortality and outcome of the treatment over the last decades can be attributed to the modulation of the hypermetabolic response to trauma. It was reported by researchers in Shrinners Hospital that propranolol administration during the hospitalization attenuates the hypermetabolism and reverses muscle catabolism. Our case is a 16 year old male burn victim admitted to DR Sardjito Hospital, after 24 hour hospitalization in a District Hospital. He was assessed as 40% grade II-III of electric injury. Fluid resuscitation with Baxter Formula and debridement of the wound were performed as the initial treatment. In the first 12 weeks of hospitalization the plasma protein was decreasing due to hypermetabolic response to the severe burn and the albumin concentration was never reach 2 g/L. Thats why the plan to do skin grafting was postponed. It was decided then to apply the Shrinners Hospital protocol, i.e. propranolol administration, to make reversal effect of catabolism. After five weeks of oral propranolol administration the albumin concentration was increasing from 1.8 to 2.9 g/I, so that we could perform split thickness skin grafting procedure. Two weekks later about 95% of the skin graft donor were viable. We came to the conclusion that the administration of oral propranolol could attenuate catabolism process and directly increase the plasma albumin concentration.Keywords : burn - propranolol - hypermetabolism slowing effect - plasma albumin concentration

The correlation between blood glucose control obesity and diabetic duration, with frequency of dermatophytosis among type II diabetic patients. Dwi Retno AW, Dwi Retno AW
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

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Objectives: The aim of this study was to determine the correlation of blood glucose control and frequency of dermatophytosis among type II diabetic patients. In addition we also assessed the dermatophytosis in correlation with obesity and diabetic duration.Materials and Methods: The study was performed using a cross-sectional study design. The subjects of this study were 180 type II diabetic patients, divided into two groups of blood glucose level (good and poor glycemic control groups). In addition, these subjects were examined for evidence of dermatophytosis, and compared between good glycemic control and poor glycemic control. Among the subjects suspected to have dermatophytosis lesions were further examined using potassium hydroxide and fungal cultures.Results: The result showed that there was seemed to be an increased frequency of dermatophytosis in poor glycemic control group in comparison with the good glycemic control group (8.3% vs 6.1 %). Statistically this difference was significant (p0.05). The combination of glycemic control and obesity in this study was seemed to have a significant correlation too.Conclusion: poor glycemic control and or obesity increased the risk for suffering from dermatophytosis in the type II diabetics, while the diabetic duration did not increase.Keywords: dermatophytosis - type II diabetes - glycemic control - obesity - diabetic duration

The effect of rifampicin administration on the pharmacokinetic profile of glipizid in normal subjects Luciana Kuswibawati, Luciana Kuswibawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

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Background: The use of antituberculosis drugs among diabetic patients is not infrequent. Among these, glipizide is one of the widely used antidiabetic drugs. The use of this second generation sulfonylurea in combination with rifampicin is common.Rifampicin is known as enzyme inductor that can influence other drugs metabolism used in combination.Objective: To investigate the effect of rifampicin pretreatment on the pharmacokinetic parameters of glipizide among 12 Indonesian healthy volunteers.Methods: Using randomized crossover design, volunteers were divided into two groups, i.e control and rifampicin pretreatment groups. Before starting the experiment, the pretreatment group was given 450 mg of rifampicin orally which should be taken daily for 7 days. Subsequently, a single dose of 5 mg glipizide was ingested to control and the pretreatment group as well. After oral administration of single dose of 5 mg glipizide, the samples were collected serially at 0; 0.5; 0.75; 1; 1.5; 2; 2.5; 3; 4; 5; 7; 9 and 12 hours to analyze blood glipizide level. High Pert ormace Liquid Chromatography (HPLC) method was used to analyze glipizide pharmacokinetic profile. From the data obtained, the pharmacokinetic parameters were calculated using noncompartment model.Results: The results showed that there were no significant change in the value of Tmax, Cmax, Ka, significant increases clearence (CI) 101.8% and elimination rate constant (Kel) 116.7% of the rifampicin pretreatment group. The elimination half life (T1/2) were shortened 39.5% from 3.8 to 2.3 hours Â (p<0.01).Â AUCO-12 dan AUCO--- of the rifampicin pretreatment group decreased by 38.7% and 44.0% respec-tively (p<0.05).Conclusion: Pretreatment with rifampicin 450 mg once daily for 7 days did not change absorption pharmacokinetic parameters of glipizid single dose of 5 mg but accelerated the elimination pharmacokinetic parameters of glipizide.Â Keywords: rifampicin-glipizide-drug interaction-pharmacokinetic-DM

Factors associated with severe malnutrition among children under five-year old in Yogyakarta during the economic crisis Endy P. Prawirohartono, Endy P. Prawirohartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

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Background: Malnutrition is a problem in under five-year old children. During the economic crisis, the nutritional status of this group has decreased. There are variety of risk factors related to severe malnutrition. Some risk factors are preventable. Recognition of preventable risk factors is important in the management of severely malnourished children in the community.Objective: To determine factors associated with severe malnutrition among under five-year old children in Yogyakarta during the economic crisis.Methods: A case control study conducted in Sleman and Bantul Districts. Thirty four severely malnourished children and 68 controls of well nourished children were enrolled in this study. There were 6 group of variables consisted of 21 factors analyzed in this study. A logistic regression analysis was done to calculate OR and 95%Cl.Results: Univariate analysis showed that low educated mother, mother who works outside home, bad water disposal, non-breastfed children, and tuberculosis were associated with severe malnutrition where their OR and 95%Cl were 2.96 (1.26 - 6.94), 2.79 (1.15 - 6.77), 12.33 (3.44 - 44.24), 4.13 (1.70 -10.02) and 9.03 (2.29 - 35.62) respectively. Using multivariate analysis only non-breastfed children, tuberculosis and bad water disposal related to severe malnutrition with OR and 95%Cl 7.01 (1.35 -36.48), 11.52 (1.43 - 92.64) and 32.64 (5.44 - 195.90) respectively.Conclusions: Breastfeeding plays important role to support nutrients and other benefits to nutritional status of the children during the economic crisis. Tuberculosis is still a main factor related to severe malnutrition compared to acute diseases.Keywords: malnutrition - under five - risk factors - breastfeeding - tuberculosis

Hereditary ovalocytosis - molecular analysis of hereditary Southeast Asian Ovalocytosis (SAO) in Bangka, South Sumatra. Suryono Yudha Patria, Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

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Background: Southeast Asian Ovalocytosis (SAO) is a hereditary asymptomatic hemolytic disease characterized by oval form erythrocytes. This morphology is rigid and related with resistency to several strains of malaria parasites. The underlying molecular genetic abnormalities include heterozygous state for mutant band 3 protein, a membrane anion transporters protein.Objectives: To characterize the SAO in Bangka, South Sumatra in molecular level, by analyzing the DNA genome of three generation family with polymerase chain reaction (PCR).Methods: The DNA genome extracted from dried blood filter paper was used as template PCR. A pair of primers was synthesized in accordance with exon 11 of band 3 gene. The PCR product was studied under UV after electrophoresis on EtBr stained 3% agarose gel.Results: Both mutant alleles showed as smaller band compared to normal allele in all 6 heterozygote SAO persons, but not in the normal 8 cases. Deletions were predicted removing nine amino acids of band 3 protein. The mutant protein was possibly carried by the ancestor from China.Conclusions: Hereditary ovalocytosis in Bangka, Sumatra Selatan was caused by specific mutation on band 3 gene which is common mutation occurred in SAO patients.Keywords: Bangka ovalocytosis - SAO - Band 3 protein - EPB3 gene deletion - PCR

Stature in Yogyakartas students and prehistoric Balinese circa 1100 A.C. Etty Indriati, Etty Indriati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

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Background: Stature is one of growth and development indicators among others such as weight, dental eruption, and bone development. Stature varies between populations and races, and changes across times and spaces.Aim of study: to understand the average stature of groups of Indonesians relative to other populations worldwide; and to understand the anthropological category of Indonesians stature. Material and methods: Subjects were students of National University of Yogyakarta consisted of 245 people. Sex, age and their statures were recorded. In addition, the stature of 47 human skeletal remains from prehistoric Bali were measured utilizing regression formula of Mongolid race.Results: The average stature of Yogyakarta National University students in 1980s was 165 cm and 152.8 cm in males and females respectively. In the 1990s, their statures were 165.4 cm and 153.7 cm respectively. The prehistoric Balinese circa 1100 A.D. had statures of 164.4 cm and 157.3 cm in males and females respectively.Conclusion: Increased stature of 0.4 cm in males and 0.9 cm in females among Yogyakarta students in one decade might have been related to better nutrition, social and economy from the 80s to the 90s. Within two millennia, Indonesian stature has not undertook significance change. Indonesian stature is medium relative to other populations stature worldwide; and in the range of stature of people from China, Hongkong, Taiwan, Thailand, and India. However, Indonesian stature is below the average stature of European and American people. This suggests that race/genetics are more prominent as contributing factors reaching terminal stature, compared to latitude (weather and geograpy).Keywords: stature, Yogyakarta, Bali, anthropology, growth

Management of early breast cancer with breast conserving treatment : Evaluation of cases in Yogyakarta T. Aryandono, T. Aryandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

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Background: Breast conserving treatment (BCT) can be done for early breast cancer, with the same survival as mastectomy. The patients should not lost the breast resulted from the treatment. Objective: To evaluate the patients with breast conserving treatment in two hospitals in Yogyakarta, in connection with locoregional recurrence, distant metastasis, cosmetic result and general condition. The results can be used for improving the technique of breast conserving treatment in this region. Methods: Five patients with BCT from 1996 until 2001 were treated with wide excision (lumpectomy), axillary dissection level I and II, and radiotherapy 5000 cGy. Histopathological examination, estrogen and progesterone receptor and c-erbB-2 examination were conducted for these patients. All patients received hormonal adjuvant treatment with tamoxifen, no one received adjuvant chemotherapy.Results: The age range was 28-51 years old, stage one, maximum diameter of tumor was 1.5 cm. Most of them were invasive duct carcinoma, with positive ER, PR and c-erbB-2. Follow up from 8 to 66 months, with median follow up 37 months. No locoregional recurrences, one with distant metastasis (lung). The cosmetic result as well as the general condition were good.Conclusions: Breast conserving treatment had been done on patients and resulted in good cosmetic result, no locoregional recurrences and good general condition. With early detection and good patient selection, the patient should have not lost the breast with the same survival as in mastectomy.Keywords: breast conserving treatment- lumpectomy - radiotherapy - estrogen receptor - progesterone receptor.

Catamenial epilepsy Harsono, Harsono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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The true frequency of menstrually related seizures (catamenial epilepsy) is unclear. This is due in part to the fact that at present there is no universally accepted definition of this entity. Because of such arbitrary definition, a variety of therapeutic strategies for controlling seizures related to hormonal fluctuations have been recommended. With respect to the uncertainty of catamenial epilepsy criteria, the principles of physiologic changes related to hormonal fluctuations in women with epilepsy should be understood. Based on the knowledge of hormonal changes and characteristics of epilepsy, a detailed history taking should be carried out properly. This strategy will be useful for establishing diagnosis and planning appropriate treatment.Keywords: catamenial epilepsy - definition - seizure - therapeutic strategy - hormonal fluctuations.

Usage of propranolol to attenuate catabolism process in burn victim : A case report Ishandono Dahlan Ishandono Dahlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.774 KB)

Burn is still a common injury faced by the surgeons. The mortality is considerably high. One of the improvement in the mortality and outcome of the treatment over the last decades can be attributed to the modulation of the hypermetabolic response to trauma. It was reported by researchers in Shrinners Hospital that propranolol administration during the hospitalization attenuates the hypermetabolism and reverses muscle catabolism. Our case is a 16 year old male burn victim admitted to DR Sardjito Hospital, after 24 hour hospitalization in a District Hospital. He was assessed as 40% grade II-III of electric injury. Fluid resuscitation with Baxter Formula and debridement of the wound were performed as the initial treatment. In the first 12 weeks of hospitalization the plasma protein was decreasing due to hypermetabolic response to the severe burn and the albumin concentration was never reach 2 g/L. That's why the plan to do skin grafting was postponed. It was decided then to apply the Shrinners Hospital protocol, i.e. propranolol administration, to make reversal effect of catabolism. After five weeks of oral propranolol administration the albumin concentration was increasing from 1.8 to 2.9 g/I, so that we could perform split thickness skin grafting procedure. Two weekks later about 95% of the skin graft donor were viable. We came to the conclusion that the administration of oral propranolol could attenuate catabolism process and directly increase the plasma albumin concentration.Keywords : burn - propranolol - hypermetabolism slowing effect - plasma albumin concentration

The correlation between blood glucose control obesity and diabetic duration, with frequency of dermatophytosis among type II diabetic patients. Dwi Retno AW Dwi Retno AW
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Nurhadiyahya

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