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All Journal International Journal of Public Health Science (IJPHS) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Sari Pediatri Paediatrica Indonesiana Berita Kedokteran Masyarakat Indonesian Journal of Biomedicine and Clinical Sciences
Suryono Yudha Patria
Department Of Pediatrics, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Central Java
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Quality of life epilepsy in childhood: Comparison between well-controlled epilepsy and non epilepsy Soeroyo Machfudz, Fita Wirastuti Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.668 KB)

Abstract

Quality of life is an important parameter in assessing the efficacy of medical interventions. Chronic diseases such asepilepsy, have a significant impact on quality of life. Childhood epilepsy is often associated with low achievement inschool, physical limitations, and disturbed social functions. The purpose of this study was to compare the quality oflife of well-controlled epileptic children with non epileptic children. This research was conducted with cross-sectionalstudy design with respondents aged 5-18 years old. All respondents were well-controlled epileptic and non epilepticchildren who were admitted to the Pediatric Polyclinic of Dr. Sardjito General Hospital, Yogyakarta, Indonesia in theperiod of March until June 2010. Measurement of quality of life was conducted by filling out the questionnairePediatrics Quality of Life (PedsQL) that directly obtained from the children who were accompanied by their parent.Lower total score of PedsQL showed better quality of life. The results showed that mean total score of PedsQL onwell-controlled epileptic children (38.31±1.6) was higher than non epileptic children (8.84±0.90). Prevalence ratioof controlled epileptic children was 2.69 (95% CI: 2.01-3.58). In conclusion, well-controlled epileptic children hadlower quality of life than non epileptic children. The factors that affect quality of life of well-controlled epilepticchildren were duration of suffering from epilepsy and age at diagnosis of epilepsy.Key words: quality of life – well-controlled epileptic children - PedsQL – physical function – emotional functionsocialfunction
Hereditary ovalocytosis - molecular analysis of hereditary Southeast Asian Ovalocytosis (SAO) in Bangka, South Sumatra. Suryono Yudha Patria, Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.476 KB)

Abstract

Background: Southeast Asian Ovalocytosis (SAO) is a hereditary asymptomatic hemolytic disease characterized by oval form erythrocytes. This morphology is rigid and related with resistency to several strains of malaria parasites. The underlying molecular genetic abnormalities include heterozygous state for mutant band 3 protein, a membrane anion transporters protein.Objectives: To characterize the SAO in Bangka, South Sumatra in molecular level, by analyzing the DNA genome of three generation family with polymerase chain reaction (PCR).Methods: The DNA genome extracted from dried blood filter paper was used as template PCR. A pair of primers was synthesized in accordance with exon 11 of band 3 gene. The PCR product was studied under UV after electrophoresis on EtBr stained 3% agarose gel.Results: Both mutant alleles showed as smaller band compared to normal allele in all 6 heterozygote SAO persons, but not in the normal 8 cases. Deletions were predicted removing nine amino acids of band 3 protein. The mutant protein was possibly carried by the ancestor from China.Conclusions: Hereditary ovalocytosis in Bangka, Sumatra Selatan was caused by specific mutation on band 3 gene which is common mutation occurred in SAO patients.Keywords: Bangka ovalocytosis - SAO - Band 3 protein - EPB3 gene deletion - PCR
Quality of life epilepsy in childhood: Comparison between well-controlled epilepsy and non epilepsy Fita Wirastuti Suryono Yudha Patria Soeroyo Machfudz
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.668 KB)

Abstract

Quality of life is an important parameter in assessing the efficacy of medical interventions. Chronic diseases such asepilepsy, have a significant impact on quality of life. Childhood epilepsy is often associated with low achievement inschool, physical limitations, and disturbed social functions. The purpose of this study was to compare the quality oflife of well-controlled epileptic children with non epileptic children. This research was conducted with cross-sectionalstudy design with respondents aged 5-18 years old. All respondents were well-controlled epileptic and non epilepticchildren who were admitted to the Pediatric Polyclinic of Dr. Sardjito General Hospital, Yogyakarta, Indonesia in theperiod of March until June 2010. Measurement of quality of life was conducted by filling out the questionnairePediatrics Quality of Life (PedsQL) that directly obtained from the children who were accompanied by their parent.Lower total score of PedsQL showed better quality of life. The results showed that mean total score of PedsQL onwell-controlled epileptic children (38.31±1.6) was higher than non epileptic children (8.84±0.90). Prevalence ratioof controlled epileptic children was 2.69 (95% CI: 2.01-3.58). In conclusion, well-controlled epileptic children hadlower quality of life than non epileptic children. The factors that affect quality of life of well-controlled epilepticchildren were duration of suffering from epilepsy and age at diagnosis of epilepsy.Key words: quality of life – well-controlled epileptic children - PedsQL – physical function – emotional functionsocialfunction
Hereditary ovalocytosis - molecular analysis of hereditary Southeast Asian Ovalocytosis (SAO) in Bangka, South Sumatra. Suryono Yudha Patria Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 01 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.476 KB)

Abstract

Background: Southeast Asian Ovalocytosis (SAO) is a hereditary asymptomatic hemolytic disease characterized by oval form erythrocytes. This morphology is rigid and related with resistency to several strains of malaria parasites. The underlying molecular genetic abnormalities include heterozygous state for mutant band 3 protein, a membrane anion transporters protein.Objectives: To characterize the SAO in Bangka, South Sumatra in molecular level, by analyzing the DNA genome of three generation family with polymerase chain reaction (PCR).Methods: The DNA genome extracted from dried blood filter paper was used as template PCR. A pair of primers was synthesized in accordance with exon 11 of band 3 gene. The PCR product was studied under UV after electrophoresis on EtBr stained 3% agarose gel.Results: Both mutant alleles showed as smaller band compared to normal allele in all 6 heterozygote SAO persons, but not in the normal 8 cases. Deletions were predicted removing nine amino acids of band 3 protein. The mutant protein was possibly carried by the ancestor from China.Conclusions: Hereditary ovalocytosis in Bangka, Sumatra Selatan was caused by specific mutation on band 3 gene which is common mutation occurred in SAO patients.Keywords: Bangka ovalocytosis - SAO - Band 3 protein - EPB3 gene deletion - PCR
Neonatal outcomes in In vitro fertilization (IVF) pregnancies Muhammad Buchori; Suryono Yudha Patria; Tunjung Wibowo; Ita Fauzia Hanoum
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.778 KB) | DOI: 10.19106/JMedSci005002201805

Abstract

small-for-gestational age (SGA), and low birth weight (LBW) rates are approximately twiceas high in IVF pregnancies than in natural pregnancies. The IVF procedures have becomemore routine in recent years in Indonesia, but there have been few assessments ofneonatal outcomes. The study aimed to evaluate the risk of preterm birth, SGA, and LBWin IVF infants. This was a retrospective cohort study performed in Dr. Sardjito GeneralHospital, Yogyakarta from January 2012 to December 2016. Pre-coded questionnaireswere used to collect data from medical records. The relative risk of preterm birth, SGA,and LBW among IVF infants were calculated and compared to naturally conceived infants.A total sampling method was used for the IVF infants and a simple random samplingmethod was used for naturally conceived infants, who were born on the same day as aninfant in the IVF group.A total of 108 infants were recruited, consisting of 54 IVF infants and 54 naturallyconceived infants. The IVF infants had increased risk of preterm birth (RR = 2.0; 95%CI0.52 - 7.58) and LBW (RR = 1.25; 95%CI 0.53 - 2.92). However, the IVF infants didnot have an increased risk of SGA (RR = 1.0; 95%CI 0.21 - 4.73). In conclusion, therisk of preterm birth and LBW in IVF infants are higher than in naturally conceived infants,but not statistically significant. However, there is no increased risk of SGA in IVF infants.
Ketepatan Waktu Pelayanan Skrining Hipotiroidism Kongenital di Yogyakarta Rini Anggraini; Suryono Yudha Patria; Madarina Julia
Sari Pediatri Vol 18, No 6 (2017)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1235.584 KB) | DOI: 10.14238/sp18.6.2017.436-42

Abstract

Latar belakang. Deteksi dan pengobatan dini hipotiroid kongenital dapat mengurangi risiko terjadinya disabilitas intelektual, sehingga ketepatan waktu pelayanan merupakan kunci keberhasilan program skrining hipotiroid kongenital (SHK) pada bayi baru lahir. Tujuan. Mengevaluasi pelaksanaan program SHK pada bayi baru lahir di Yogyakarta tahun 2013-2015. Metode. Data ketepatan waktu pengambilan, pengiriman spesimen ke laboratorium dan data umpan balik hasil skrining dikumpulkan melalui catatan dan pelaporan program di fasilitas pelayanan kesehatan, Dinas Kesehatan Provinsi DIY dan Laboratorium Patologi Klinik FK UGM. Hasil. Persentase pengambilan spesimen yang tidak tepat waktu pada kelompok dana pemerintah (25%-32%) lebih besar daripada kelompok dana mandiri (11%-15%). Persentase pengiriman spesimen ke laboratorium yang tidak tepat waktu dari kelompok dana pemerintah (38%-45%) lebih besar daripada kelompok dana mandiri (7%-11%). Hasil tes TSH tinggi diterima oleh Dinas Kesehatan Provinsi DIY/Patologi Klinik UGM ketika usia bayi sudah lebih dari 2 minggu, sedangkan hasil tes yang tidak terbaca diterima ketika usia bayi 22-59 hari. Kesimpulan. Setelah dilaksanakan hampir 10 tahun, cakupan program skrining hipotiroid kongenital di Yogyakarta baru mencapai 10% bayi baru lahir. Masih banyak terjadi ketidaktepatan waktu pelayanan. Alur jejaring kerjasama program juga kurang efisien.
Faktor Risiko Sekuele Meningitis Bakterial pada Anak Muriana Novariani; Elisabeth Siti Herini; Suryono Yudha Patria
Sari Pediatri Vol 9, No 5 (2008)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.409 KB) | DOI: 10.14238/sp9.5.2008.342-7

Abstract

Latar belakang. Mortalitas akibat meningitis bakterial menurun dengan ditemukan antibotik yang potendan penanganan yang baik pada saat pasien kritis. Walaupun demikian, sekuele akibat meningitis bakterialmasih tinggi, sekitar 50%-65% di negara berkembang.Tujuan. Mengetahui faktor risiko yang terkait dengan sekuele pada pasien meningitis bakterial yangbertahan hidup.Metode. Penelitian kasus kontrol dilakukan di RSUP Dr. Sardjito, RSUD Banyumas dan RSU SuradjiTirtonegoro Klaten. Kasus adalah pasien yang terdiagnosis meningitis bakterial pada tahun 2003 – 2006yang hidup dengan sekuele. Kontrol adalah pasien meningitis bakterial yang hidup tanpa sekuele. Datadiambil dari catatan medis, luaran ditetapkan setelah 6 bulan.Hasil. Terdapat 78 pasien yang memenuhi kriteria inklusi. Hasil analisis multivariat menunjukkan bahwafaktor risiko yang terkait dengan meningitis bakterial adalah kejang >30 menit saat masuk rumah sakit(OR 4,29; IK 95% 1,38–12,99), PCS (Pediatrics Coma Scale) <8 (OR 3,76 ; IK 95% 1,15-12,28), dankejang yang tidak terkontrol >72 jam (OR 5,24 ; IK 95% 1,49–18,43). Onset - gejala >48 jam mempunyaiOR 2,43 (IK 95% 0,73 – 8,13).Kesimpulan. Kejang >30 menit saat masuk rumah sakit, PCS <8, dan kejang yang tidak terkontrol >72 jammerupakan faktor risiko yang indipenden untuk menimbulkan sekuele.
Detection of the jaundice-related G71R mutation in the UGT1A1 gene by denaturing high performance liquid chromatography (DHPLC) Retno Sutomo; Sunartini Hapsara; Suryono Yudha Patria; Hajime Nakamura
Paediatrica Indonesiana Vol 49 No 1 (2009): January 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.816 KB) | DOI: 10.14238/pi49.1.2009.1-6

Abstract

Background  The  G71R mutation in the UGT1A1 gene has  beenassociated with neonatal jaundice  and  other  cases  of  hereditary,unconjugated hyperbilirubinemia in several Asian populations.Currently,  DNA  sequencing  is  the  only  method  available  toidentify the mutation, which can be time- and  labor-intensive,particularly for such projects  as  population-based genetic studies.A relatively new method, denaturing high performance liquidchromatography (DHPLC),  is  increasingly used to  detect  variousmutations.Objective  The  aim  of  the present study was to investigate theability of DHPLC to  detect  the G71R mutation, in comparisonwith the gold standard of sequencing analysis.Methods Seventy-two infants were enrolled. Following genomicDNA  extraction, exon 1 of the UGT1A1 gene was amplified  bypolymerase chain reaction (PCR). Afterwards, the G71R mutationwas simultaneously,  and  blindly, determined in all subjects  byDHPLC and sequence analysis.  The  performance  of  the DHPLCanalysis, compared  to  the sequence analysis, was assessed in termsof  sensitivity  and  specificity.Results DHPLC detected the G71 R mutation in  31  individuals.Of  these,  26  were heterozygous and 5 were homozygous for themutation. This method did not find the mutation in  41  otherindividuals. Sequence analysis produced identical results for allindividuals.Conclusion DHPLC analysis  is  capable  of  detecting the G71Rmutation  in  the  UGT1A1  with  a degree  of  sensitivity  andspecificity  (100%  each)  that  is  comparable to sequencing analysis.
Predictive factors of ketoacidosis in type 1 diabetes mellitus Listianingrum Listianingrum; Suryono Yudha Patria; Tunjung Wibowo
Paediatrica Indonesiana Vol 59 No 4 (2019): July 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.118 KB) | DOI: 10.14238/pi59.4.2019.169-74

Abstract

Background Diabetic ketoacidosis (DKA) is an acute complication in type 1 diabetes mellitus (DM) and a significant cause of morbidity and mortality in developing countries. Diabetic ketoacidosis can be prevented by good management of the disease. Risk factors from previous studies that increase the DKA incidence were peripubertal age, female gender, low socio-economic status, low parental education status, DKA at the first diagnosis of type 1 DM, infection, psychological problems, poor metabolic control, and non-compliance with insulin treatment. Objective To determine whether sex, age, socio-economic status, parental education level, DKA at the initial diagnosis of type 1 DM, infection, psychological problems, poor metabolic control, and failing to take insulin as needed were predictive of DKA in type 1 DM patients. Methods We conducted a retrospective cohort study using medical records from type 1 DM patients aged 0-20 years, at the Department of Child Health, Dr. Sardjito Hospital, Yogyakarta, from January 2011 to May 2017. We assessed for the incidence and predictors of DKA. Logistic regression analysis was done to determine which factors increased DKA incidence. Results A total of 57 type 1 DM patients were recruited, with DKA incidence of 37 (65%). Five (8.8%) DKA patients died. Multivariate analysis revealed that infection (OR 5.23; 95%CI 1.47 to 19.68; P=0.014) and DKA at the first diagnosis of type 1 DM (OR 5.37; 95%CI 1.40 to 19.52; P=0.011) were significant risk factors for DKA. Conclusion Infection and DKA at the first diagnosis of type 1 DM are significant predictors of increased DKA incidence.
The outcomes of childhood acute lymphoblastic leukemia with hyperleukocytosis Din Alfina; Pudjo Hagung Widjajanto; Suryono Yudha Patria
Paediatrica Indonesiana Vol 58 No 4 (2018): July 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.109 KB) | DOI: 10.14238/pi58.4.2018.186-91

Abstract

Background Hyperleukocytosis in childhood acute lymphoblastic leukemia (ALL) is an emergency in oncology. This condition showed high mortality and relapse rates, as well as low survival rate. The outcomes of this group of patients are not yet well studied. Objective To evaluate the characteristics and outcomes of childhood acute lymphoblastic leukemia (ALL) with hyperleukocytosis. Methods This was a retrospective cohort study. The patients were children less than 18 year of age who were diagnosed as ALL in Dr. Sardjito Hospital, Yogyakarta, from January 1st 2010 to November, 30th 2016. Event-free survival rate and overall survival rate were estimated for group of patients with the white blood cell (WBC) groups 50-200x109/L and >200x109/L using the Kaplan-Meier method. Results There were 705 children diagnosed as ALL during the study period, 129 (18%) with hyperleukocytosis and 111 of them met the inclusion criteria, consisted of 76 children in a group of WBC 50-200 x 109/L and 35 children in a group of WBC >200 x 109/L. Presentation at diagnosis: median age were 7 years (range 1 month-18 years), male was 1.5 higher than female, 92% of cases with lymphoid infiltration, 5% with CNS involvement, 40% had bleeding tendency, and 10% had clinical tumor lysis syndrome (TLS). Median WBC was 122 (range 53.4-876) x 109/L; mean Hb was 8 (SD 3) g/dL; median platelet count was 30 (range 1-221) x 109/L. Immunophenotyping was done in 23 patients, 5/23 (8%) was T cell. The patients in lower WBC group showed lower death (26% vs. 34%, P=0,389), higher two-year event-free survival (EFS) 68% vs. 45%, P=0.003, and overall survival (77% vs. 68%, P= 0.16), compared to patients in higher WBC group. Univariate and multivariate Cox regression analyses revealed that none of the variables was a significant prognostic factor for 2 years EFS or overall survival. Conclusion The group of children with ALL and hyperleukocytosis with lower WBC at diagnoses showed better outcomes than the higher WBC.
Co-Authors Agung Triono Cahya Dewi Satria Dibyo Pramono Dikahayu Alifia Anugrah Din Alfina Elisabeth Siti Herini Hajime Nakamura Indah Kartika Murni Ita Fauzia Hanoum Listianingrum Listianingrum Madarina Julia Muhammad Buchori Muriana Novariani Nadya Arafuri Noormanto Noormanto, Noormanto Priscila Evangelin Asa Pudjo Hagung Widjajanto Retno Sutomo Rini Anggraini Sabella Rahmawati, Rhea Sasmito Nugroho, Sasmito Sunartini Hapsara Tri Ratnaningsih Tunjung Wibowo Tunjung Wibowo Windarwati, Windarwati Wirawan, Muhammad Taufik