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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2 Documents
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Search results for , issue "Vol 9 No 3 (2019): Medula" : 2 Documents clear
Vitamin D sebagai Pencegahan Penyakit Degeneratif hingga Keganasan: Tinjauan Pustaka Riskita Fiannisa
Medula Vol 9 No 3 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Vitamin D is a vitamin that is often forgotten but has many benefits that are very beneficial for our body. Vitamin D or alsocalled a sunshine vitamin is obtained from inside the body and outside the body. The source from the body that vitamin Dcomes from 7-dehydroxylase which is in the epidermis and dermis layer which will transform into an active form of vitamin Dproduced by UVB radiation. Vitamin D which is synthesized with the help of sunlight is the main supply of vitamin D and thatlasts longer than vitamin D which comes from food sources. Factors causing vitamin D deficiency such as sunscreen, skinpigmentation, dress code, elderly, season and temperature of the region, medical conditions such as liver disorders, chronickidney disorders, and use of anticonvulsants, fat malabsorption, and obesity can use their use of vitamin D content inside thebody. There are many diseases related to vitamin D in the body, such as osteoporosis, rickets, fractures, weakness, cancer,diabetes, fat malabsorption, chronic kidney disorders, liver disorders and obesity. This research discusses the importance ofvitamin D for the body and can also help vitamin D in preventing various diseases. The benefits of vitamin D for the body canprevent diabetes, prevent cancer, and prevent cardiovascular disease, osteoporosis, and rickets.
Association Of Triple Negative Breast Cancer (TNBC) With BRCA-1 Mutation And Ethnicity Permana, Km. Allan Wahyu; Permana, M. Agung Yudistira; Nisa, Sayyidatun; Sukohar, Asep
Medula Vol 9 No 3 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i3.1109

Abstract

Breast cancer is the most common cancer suffered by women in the world, 15-20% is a subtype of triple negative breast cancer (TNBC). TNBC is a subtype of breast cancer that does not express genes for estrogen receptors (ER), progesterone receptors (PR) and HER2 overexpression, which is clinically more aggressive and unresponsive to standard therapy, thus it can worsen the prognosis. It suggests that TNBC is associated with BRCA-1 gene mutation, moreover in African-Americans. So this study aims to determine the association of TNBC with BRCA-1 gene mutation and ethnicity. International journal literature review. BRCA-1 gene mutations increased 45%-85% of the risk of breast cancer growth and 15% -25% of TNBC have BRCA-1 gene mutations which resulted in activation inefficiencies of the HR DNA repair pathway. TNBC occurred in 60% of the black race, disproportionate incidence of TNBC greater in African ethnicity compared to other ethnic groups in the world and has the worst prognosis among all races. There is asignificant association between TNBC with BRCA-1 gene mutations and ethnicity especially in African-Americans.

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