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INDONESIA
Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 5 Documents
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Search results for , issue "Vol. 1 No. 1 (2004)" : 5 Documents clear
PENGARUH PRAPERLAKUAN JUS PISANG AMBON ( Musa paradisiaca L. ) TERHADAP BIOAVAILABILITAS SULFAMEZATIN PADA TIKUS PUTIH JANTAN Hayati, Farida; Hakim, Arief Rahman; Riptasari, Rhatna Dewi
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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The influence of ambon banana’s fruit ( Musa paradisiaca L. ) juice on the bioavailability of sulfamezathin on the rat that aim to know there are interaction result from their consumption together has been studied. The study was using experiment’s animal is white rats Wistar’s spesies that have age around 3-4 months and their weight 200-300 g. This experimental was used completely randomized design with three group’s test, each group’s test is contain seven rats. The first group is pretreatment single dose sulfamezathin (60 mg/kg ww; peroral ), second is sullfamezathin and banana ( 12,6 g/kg ww; peroral ) together and third group is sulfamezathin after one hour dose banana like second group. Respectively blood samples take up from tail vein of rat at 15, 30, 45, 60, 90, 120, 150, 180, 240, 360, 480 and 600 minutes. Consentrations of Sulfamezatin were measured use Bratton Marshall methode with spektrofotometer instrument at 545 mn wavelength. Consentrations of sulfamezathin versus times by software of Stripe used to calculate pharmacokinetics parameters in each group’s test and the value parameters of pharmacokinetics have statistic analysis by ANOVA and if there are difference’s significant ( p < 0,05 ) from calculated value, statistic analysis continued by Tukey test. The results from experimental banana at second and third groups in compare with control at the first group can increased significant ( p < 0,05 ) parameters C maks, t maks, AUC0- .Bioavailability, Sulfamezathin, Ambon banana, Musa paradisiaca L.
EFEK ANTI PROLIFERATIF EKSTRAK ETANOL KULIT BATANG TANAMAN CANGKRING (Erythrina fusca Lour) TERHADAP SEL MYELOMA Meiyanto, Edy; Sismindari, Sismindari; Triastuti, Asih
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTErythrina fusca Lour has been traditionally used to cure hepatosis, malaria, hematuria, andcancer. The bark of this plant contains  carotene, polifenol, thiamin, saponin, and alkaloiderythralin and erythramin. The aim of this research was to know the underlying mechanism of itseffect as antiproliferative against Myeloma cells. The bark powder was extracted using ethanol(70%) and was used for the experiment after freezed drying. Citotoxicity test of this extractperformed LC50 of 0,367 mg/ml. The rate of proliferation was observed by doubling time effectagainst proliferating cells. The cells were exposed with ethanolic extract in RPMI 1640 mediumcontaining 1) 0,25 mg/ml 2) 6,25x10-2mg/ml, and 3) 1,56x10-2mg/ml and every 0, 6, 12, 24, 48,and 72 hours cell were counted. The result showed that extract treated cells delayed proliferation atall concentration with doubling time dose 2) of 161, 38 hours, and dose 3) of 93,91 hours, whereasdoubling time of control cells were 69,86 hours. Ethidium bromide staining of extract treated cellsshowed apoptosis like profile. These results indicated that ethanolic extract of the bark of Erythrinafusca Lour has an antiproliverative effect on Myeloma cell line. Several mechanisms might accountfor this effect, like inhibiting cell cycle progression, signal transduction, causing delayed andapoptosisKeywords: Erythrina fusca Lour, atiproliferative, Myeloma
POLA PENGGUNAAN OBAT UNTUK PENDERITAGAGAL GINJAL AKUT DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM PUSAT (RSUP) DR. SARDJITO YOGYAKARTA TAHUN 1997-2001 Hanifah, Suci
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTDrug Utility Review for ARF’ patients of Internal Unit, Sardjito’s hospital was examed. Itinvolved 109 ARF’s patients. Medical Record Unit reported that this number was 0,12% of alldisese i.e. 93.445 case in 2001. The level was 93rdfrom 945 kind of disease. It was studied bynonanalitical descriptive design. using notes of Medical Record system. Collecting of data byretrospektive methode. This research was aimed to study the Drug Utility Review for ARF’spatients, especially to study ; drug variation included kind and class of drugs, route ofadministration, variation drug number, length of stay, and regimen dosage of drugs. To complete it,mortality persentaged was reported. The result of the study showed that ARF’s patients got somany variation of drugs. Using of antibiotic, diuretic, and electrolit was the most case. It conformedto Health Care Standard in Sardjito’s hospital. The others was aimed to simptomatical drugs i.e.antihypertensi, cardioasculer drugs, analgetic, antiemetic, multivitamin, laxan etc. It depended onsymptoms and complication of patients. Variation of number between 1-24. The average numberwas 7,7 drugs. It tended to use new generation of antibiotic and combinatins antibiotic, as indicatorof extravagant prescibing. Route of administratin by orally in most case and 38 % by injection.Injection route so indicate extravagant prescibing except on emergency care. The others used bysublingual and suppositoria. Length of stay averaged 12,52 days. Mortality persentaged was 22%.Key words : Drug Utility Review, ARF, Medical Record,Extravagant Prescribing
SENYAWA INSEKTISIDA DARI TANAMAN Hidayati, Atik
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTThe importance of insecticides in agricultural and economic aspects is undoubted. But thenegative impacts that arise lead to the discovery of new ones. A high number of insecticidal agentsare synthesized by plant species. They are of interest in that chemical modification of the naturalproduct can open the way to novel, synthetic insecticides.Key words: insecticides, Spodoptera litura
SISTEM PENGHANTARAN OBAT MELEWATI BARRIER DARAH OTAK Syukri, Yandi
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTBrain barrier is effective barrier in drug delivery to brain. For effectiveness drug deliveryneed be desaigned a delivery with nanoparticle technology. Nanoparticles are solid colloidalparticles ranging in size from 1 to 1000 nm that are utilized as drug delivery agents. The primaryadvantages of nanoparticle carrier technology is that nanoparticles mask the blood – brain barrierlimiting characteristics of the therapeutic drug molecule. Furthermore, this system may slow drugrelease in the brain, decreasing peripheral toxicity. The method which elaboration in manufacturenanoparticles are emulsion polimerization, interfacial polimerization, desolvation evaporation andsolvent deposition. Currently, report evaluating nanoparticles for brain delivery have studiedanesthetic and chemoterapeutic agent. These studies are reviewed for efficacy and mechanisms oftransport. Physiological factors such as phagocytic activity of the reticuloendothelial system andprotein opsonization may limit the amount of brain delivered drug. Nanoparticle technology appearsto have significant promise in delivering therapeutic molecules across the blood-brain barrier.Key Word : Drug Delivery System, Nanoparticle, Blood-Brain Barrier

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