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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Majalah Obat Tradisional IJCER (International Journal of Chemistry Education Research) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Pengabdian Magister Pendidikan IPA
Asih Triastuti
Department Of Pharmacy, Universitas Islam Indonesia, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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FORMULASI TABLET HISAP EKSTRAK GAMBIR (Uncaria gambir (Hunter) Roxb.) DENGAN VARIASI BAHAN PENGIKAT GOM ARAB (Gummi Acaciae) Triastuti, Asih; Irianti, Rischi Dwi; Chabib, Lutfi
Majalah Obat Tradisional Vol 15, No 2 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.367 KB) | DOI: 10.14499/mot-TradMedJ15iss2pp%p

Abstract

Gambir merupakan salah satu tanaman obat yang biasa digunakan untuk menyirih, yang mempunyai manfaat untuk kesehatan mulut dan gigi. Gambir ini memiliki khasiat sebagai obat pelega tenggorokan, obat sakit perut, sakit gigi, dan dapat digunakan untuk mencegah terbentuknya plak gigi. Penelitian ini bertujuan untuk membuat ekstrak gambir  menjadi sediaan obat dalam bentuk tablet hisap. Dalam tablet hisap ini digunakan variasi bahan pengikat gom arab untuk mendapatkan konsentrasi bahan pengikat yang dapat menghasilkan tablet yang memenuhi persyaratan. Ekstrak gambir diperoleh dengan metode maserasi, dengan pelarut etanol 80%. Tablet diformulasi dengan konsentrasi bahan pengikat gom arab 10%, 17,5% dan 25% menggunakan metode kempa langsung. Hasil analisis menunjukkan bahwa variasi konsentrasi gom arab dapat memperkecil variasi keseragaman bobot, meningkatkan kekerasan, menurunkan % kerapuhan, dan meningkatkan waktu larut tablet hisap. Ketiga tablet memiliki sifat fisik tablet yang baik. Tablet hisap formula 3 yang paling bisa diterima oleh responden baik dari segi warna, rasa, dan waktu larutnya. 
PENGARUH TRAGAKAN SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK JAHE (Zingiber officinalle Roxb.) Taurina, Wintari; Syukri, Yandi; Triastuti, Asih
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.951 KB) | DOI: 10.14499/mot-TradMedJ18iss2pp%p

Abstract

Jahe (Zingiber officinale Roxb.) merupakan salah satu tanaman obat yang berkhasiat sebagai obat batuk, pelega perut, obat rematik serta penawar racun, dan telah lama digunakan dalam bentuk jamu. Penelitian ini bertujuan untuk membuat sediaan obat tradisional yang lebih praktis, ekonomis, stabil, dan bernilai estetis dalam bentuk tablet hisap ekstrak jahe. Pertama dilakukan ekstraksi dari serbuk jahe, kemudian dibuat ekstrak kental dan diformulasi menjadi tablet hisap menggunakan metode granulasi basah dengan variasi konsentrasi bahan pengikat tragakan berturut-turut adalah 5%, 7,5%, dan 10%. Granul yang dihasilkan diuji sifat fisiknya berikut dievaluasi sifat fisik tablet dan tanggapan rasa serta waktu melarut di dalam mulut. Data yang diperoleh dianalisis menggunakan korelasi Pearson dengan taraf  kepercayaan 99%. Semua formula dengan variasi konsentrasi bahan pengikat tragakan dapat menghasilkan sifat fisik tablet hisap yang baik dalam memenuhi persyaratan. Dari hasil penelitian terlihat bahwa semakin besar konsentrasi tragakan  yang digunakan menyebabkan % penyimpangan bobot tablet dan kerapuhan semakin kecil, kekerasan akan semakin besar serta memperlama waktu melarut tablet. Diantara formula, tablet dengan konsentrasi tagakan 10% menghasilkan sifat fisik yang paling optimal dengan penyimpangan bobot 0,98%, kekerasan 10,18 kg, dan kerapuhan 0,11% serta waktu melarut 11,50 menit. Pada uji tanggapan rasa ketiga formula sebagian besar diterima responden dengan syarat meningkatkan kemanisan dan memperbaiki bentuk dan warnanya.
Peningkatan Ketahanan Keluarga Dalam Menghadapi Pandemi Covid-19 Melalui Vaksin dan Pembuatan Ramuan Herbal Peningkat Sistem Imun Asih Triastuti; Arde Toga Nugraha; Riyanto; Yon Haryanto
Jurnal Pengabdian Magister Pendidikan IPA Vol 5 No 1 (2022): Januari - Maret
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (365.468 KB) | DOI: 10.29303/jpmpi.v5i1.1259

Abstract

Since it was declared a pandemic by the World Health Organization, Covid-19 has significantly altered the behavior and way of life of the global community, as well as the majority of the Indonesian people. This has ramifications for the resilience of families. A strong family resilience will benefit the family's ability to deal with the various impacts and changes caused by the pandemic and post-pandemic problems. According to various reports, community empowerment is critical to the pandemic's success. Communities with a strong health culture, educational and social foundation will be successful in responding to, analyzing, and resolving pandemics (and other health/social problems that may arise) using quantifiable strategies that can actively support the government policies. The purpose of this activity is to foster a society with physically and mentally healthy, educated, and has a healthy culture. The Pucung-Umbulsari village is located 24 kilometers from the campus of the Univesitas Islam Indonesia, is a partner in this service. Promotional activities for the covid-19 vaccine and the workshop of herbals to boost the immune system are carried out based on the results of the initial need assessment conducted by the proposer and community officials (heads of RT and RW). The activities are part of the community recovery process, which includes addressing issues that arose during the pandemic and preparing people to adapt to new normal. While maintaining health protocols, health promotion activities and training are conducted. The social impact of this community service activity are an increase in public awareness of the COVID-19 vaccine in preventing the spread of the disease and the high participation and initiative of the society to produce herbals.
PROTECTIVE EFFECTS OF ETHYL ACETATE FRACTION OF Phaleria macrocarpa (Scheff) Boerl. ON OXIDATIVE STRESS ASSOCIATED WITH ALLOXAN-INDUCED DIABETIC RATS Asih Triastuti; Jong Won Choi
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTOxidative stress resulting from the increased production of reactive oxygen species playsa key role in the development of diabetes mellitus and its complications. Phaleria macrocarpa, atraditional plant from Indonesia, has been used empirically to control cancer, arthritis, and diabetesin society. The anti-diabetic effect and antioxidant activity of ethyl acetate (EtOAc) of Phaleriamacrocarpa (PM) was investigated in alloxan-induced diabetic rats. After two weeks administrationof PM, liver antioxidant enzyme and hyperglycemic state were evaluated. The result showed thatEtOAc fraction treatments reduced blood glucose levels in diabetic rats by oral administration(P
BAHAN ALAM (NATURAL PRODUCTS) SEBAGAI AGEN KEMOPREVENTIV DAN KEMOTERAPI KANKER Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTMedicinal plant has formed the basis of sophisticated traditional medicine systems that havebeen existed for thousands of years. Many advances in the chemistry of novel bioactive naturalproducts are reported. This article looks at potential chemotherapeutic and chemopreventive ofsome natural products such as curcumin, polyphenol, and dietary phytochemicals. Apparently, themedicinal plants will be continue to be important source of lead compounds for the new drugdiscovery and development in the future especially for the new anti cancer drug.Key word: bahan alam, kemopreventiv, kemoterapi, kanker
UJI KEPEKAAN BAKTERI Escherichia coli HASIL ISOLASI DARI URIN PASIEN RUMAH SAKIT Dr. Sardjito TERHADAP ANTIBIOTIK GOLONGAN -LAKTAM Sri harnanik; Sri Mulyaningsih; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTUncontrolled use of antibiotic caused the emergence of bacteria strain resistant toward of antibiotic. The sensitivity assay of E. coli toward -lactam antibiotic has been done. The sensitivity assay was started with isolated bacteria from patients urine at Dr. Sardjito hospital followed by count total of colony/number of germ which growth and identified the bacteria. The Kirby Bauer method was performed. Antibiotic impregnated disk (ampicillin 30 g, sulbactam/ampicillin 20 g, cefotaxim 30 g, ceftazidime 30 g, ceftriaxon 30 g, cefpirom 30 g, cefepim 30 g and imipenem 10 g) were placed on agar plate previously streaked with suspension of E. coli (1.10 8 CFU/ml). The plates were incubated for 18-24 hours at 37 0 C. The diameters of the zone inhibition were measured, and compared to standar interpretive zone sizes. The result of the study showed that all of E. coli resistant toward antibiotic ampicillin; 65% resistant toward antibiotic sulbactam/ampicillin; 50% still sensitive toward antibiotic third cefalosporin generation that is cefotaxim, ceftazidime, ceftriaxon; more than 50% sensitive toward fourth cefalosporin generation like cefepim, cefpirom and all of pathogen bacteria E. coli sensitive toward antibiotic imipenem.Key Words : E. coli, -lactam antibiotic, Sensitivity assay, Urine of patient hospital.
ISOLATION AND IDENTIFICATION OF FLAVONOIDS FROM WATER FRACTION OF SECANG WOOD (Caesalpinia sappan. L) WITH THIN LAYER CHROMATOGRAPHY AND UV-VIS SPECTROPHOTOMETRY METHODS Lolyta Fournia Sari; Suparmi Suparmi; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTAim of this research was to determine chemical structure of flavonoid from water fraction ofSappan wood. The flavonoid was isolated by Soxhlet xtraction using methanol and infundation.First, the detection of flavonoid was done using Thin Layer Chromatography (TLC) with statioramphase silica gel GF 254 and mobile phase ethyl acetate : acetyc acid 15 % (9:1 v/v) smoked byNH3, and detected under UV 366 nm, showed 5 spots with hRf 7, 50, 61, 68, and 80. PreparatifTLC was done to water fraction, disolveed in methanol and detected with UV-Visspectrophotometry using diagnostic reagents NaOH, NaOAc, NaOAc+H3BO3, AlCl3, ACl3+HCl andcompared with references. In fraction 1, 2, and 5 showed isoflavon with 7-OH, substitution oxygenin position six. In fraction 3 showed isoflavon with 7-OH, substitution oxygen in position six, 6,7diOH in A ring, and o-diOH in 6,7 or 7,8. In fraction 4 showed isoflavon with 7-OH, substitutionoxygen in 6, o-diOH in 6,7 or 7,8 and 5-OH.Key Words: Caesalpinia Sappan. L, Flavonoid, TLC, UV-Vis Spectrophotometry
PERBANDINGAN EFEKTIVITAS TRAGAKAN DAN PVP SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK JAHE (Zingiber officinale Roxb.) Wintari Taurina; Melinda Dewi M; Yandi Syukri; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTGinger (Zingiber Officinale Roxb) is a traditional plants usually used to relieve pain, rheumatism,and neutralize poison. The aim of this study was to get the optimum concentration of tragacanthand PVP as a binding agent in ginger lozenges formulation. The components from ginger wereextracted using percolation with ethanol 70% and then evaporated using rotary evaporator.Lozenges were made in three formulas ; formula 1 (5%), 2 (7,5%), 3 (10%) of tragacanth and PVPusing wet granulation method. Granules and tablets were tested for its physical properties, andanalyzed using Pearson correlation. The result showed that, all of three formulas were good,comply with a regulation of physical properties and disolution time in the mouth. Variation oftragacanth and PVP concentration affected physical properties of tablets. It showed that the greaterconcentration of tragacanth and PVP, the larger the hardness and the longer the disolution time oftablets. The third formula (tragacanth 10% b/v) gave an optimum physical properties and solubletime of tablets, with weight variety deviation 0,98%, hardness 10,18 kg, friability 0.11% anddisolution time 11.50 minutes. The three formulas were received by respondens withprerequirement of improving sweetness, repairing form and the color of tablets.Key words :Ginger lozenges, tragacanth, PVP, wet granulation method.
Uji Kepekaan Bakteri Escherichia Coli Hasil Isolasi Dari Urin Pasien Rumah Sakit Dr. Sardjito Terhadap Antibiotik Golongan P-Laktam Sri Harnanik; Sri Mulyaningsih; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

Uncontrolled use of antibiotic caused the emergence of bacteria strain resistant toward of antibiotic. The sensitivity assay of E. coli toward p-lactam antibiotic has been done. The sensitivity assay was started with isolated bacteria from patients urine at Dr. Sardjito hospital followed by count total of colony/number of germ which growth and identified the bacteria. The Kirby Bauer method was performed. Antibiotic impregnated disk (ampicillin 30 ng, sulbactam/ampicillin 20 ng, cefotaxim 30 ng, ceftazidime 30 jig, ceftriaxon 30 ng, cefpirom 30 ng, cefepim 30 ng and imipenem 10 ng) were placed on agar plate previously streaked with suspension of E. coli (1.10 CFU/ml). The plates were incubated for 18-24 hours at 37° C. The diameters of the zone inhibition were measured, and compared to standar interpretive zone sizes. The result of the study showed that all of E. coli resistant toward antibiotic ampicillin; 65% resistant toward antibiotic sulbactam/ampicillin; 50% still sensitive toward antibiotic third cefalosporin generation that is cefotaxim, ceftazidime, ceftriaxon; more than 50% sensitive toward fourth cefalosporin generation like cefepim, cefpirom and all of pathogen bacteria E. coli sensitive toward antibiotic imipenem.
Fungal endophytes as the source of medicinal natural product Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 16 No. 1 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss1.art6

Abstract

AbstractMassive exploration of medicinal plants as a source of medicinal raw materials and high demand for traditional medicines on the market has been a threat to biodiversity and plant species. To respond to the challenge of more efficient access to chemical diversity in a sustainable way, researchers have begun to focus their research on renewable sources, under-explored, but that have the prospect as the reservoir of new structures of bioactive metabolites, namely fungal endophytes. Fungal endophytes grow within the internal tissue s of the plant, without causing pathogenic symptoms have succeeded in producing secondary metabolites with diverse chemical structures and pharmacological activities such as antibacterial, antifungal, insecticide, antioxidant, anti hyperlipidemia, cytotoxic and anticancer. However, under conventional laboratory conditions, a plethora of secondary metabolites encoded in fungal endophytes were not produced presumably because the genes responsible for the secondary metabolites biosynthetic are not transcribed (remain silent). Several methods have been explored to activate these silent genes, including optimization parameters of fermentation, co-culture techniques, precursors/ plant extracts feeding, the addition of epigenetic modifiers such as DNA methyltransferase (DNMT) or histone deacetylase (HDAC) inhibitors, and genetic manipulation of biosynthetic and regulatory genes. The approaches in culture techniques are expected to bridge the debate in drug discovery and natural material production from endophytic fungi.Intisari Eksplorasi besar-besaran tanaman obat sebagai sumber bahan baku obat dan tingginya permintaan akan obat tradisional di pasaran telah menimbulkan permasalahan dalam biodiversitas dan ancaman bagi spesies tanaman. Peneliti bahan alam telah mulai memfokuskan penelitannya pada sumber terbarukan yang belum tereksplorasi namun memiliki prospek sebagai penyedia keanekaragaman struktur kimia, yaitu jamur endofit. Jamur endofit hidup di dalam jaringan tanaman tanpa menimbulkan simptom patogenik dan telah dilaporkan menghasilkan metabolit sekunder dengan struktur kimia yang beragam dengan aktivitas farmakologi yang luas seperti antibakteri, antijamur, insektisida, antioksidan, antihiperlipidemia, sitotoksik dan antikanker yang sangat potensial untuk dikembangkan dalam industri farmasi. Dalam pengembangannya, pemanfaatan jamur endofit memiliki beberapa kendala, utamanya dalam teknik kultur / fermentasi dalam rangka mengaktifkan gen penyandi biosintesis metabolit sekunder yang relatif inaktif selama kultur. Metode untuk mengaktifkan gen diam (silent gene) dapat dilakukan dengan beberapa cara yaitu: optimasi parameter fermentasi, teknik ko-kultur, penambahan prekursor atau zat antara ke dalam media kultur, penambahan modifikator epigenetik seperti inhibitor DNA methyltransferase (DNMT) dan atau inhibitor histone deacetylase (HDAC), dan manipulasi genetik. Pendekatan dalam teknik kultur jamur endofit diharapkan dapat menjembatani permasalahan dalam penemuan obat dan produksi bahan alam dari jamur endofit. Kata kunci: Jamur endofit, Aktivitas farmakologi, Aktivasi gen diam 
Co-Authors Amalia, Senya Putri Anjayani, Nuri Arde Toga Nugraha Edy Meiyanto Jong Won Choi LINDA SUKMARINI Lolyta Fournia Sari Lutfi Chabib, Lutfi Melinda Dewi M Pramundita Ramadani, Arba Primahana, Gian Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Riyanto Sismindari . Sri harnanik Sri harnanik Sri Mulyaningsih Sri Mulyaningsih Suparmi Suparmi Tamhid, Hady Anshory Uzulul Hikmah Wintari Taurina Yandi Syukri Yon Haryanto