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INDONESIA
Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 6 Documents
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Search results for , issue "Vol. 3 No. 1 (2006)" : 6 Documents clear
ASPEK FARMAKOLOGI TETRAHIDROKURKUMIN: METABOLIT UTAMA KURKUMIN Agung Endro Nugroho
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTTetrahydrocurcumin is a main metabolite product from biotransformation process of curcuminin the body. Biotransformation of curcumin is fast and occurred during absorption process ingastrointestinal tract. The biotransformation of curcumin to tetrahydrocurcumin and the stability oftetrahydrocurcumin play important roles in the biological effects of curcumin in the body. Thepresent article discussed about the pharmacological aspects of tetrahydrocurcumin.Tetrahydrocurcumin was reported possessing several pharmacological activities such as:antioxidant, anti-inflammatory, hepatoprotector, anti-allergy, protective for atherosclerosis and renaldamage, and also anticarcinogenesis. It’s main pharmacological activity is antioxidant, which isunderlying and responsible for the other activities. The antioxidant activity of tetrahydrocurcuminwas reported better than this of curcumin. The main factors for the antioxidant or free radicalscavenger effects of tetrahydrocurcumin are it’s aromatic/phenolic hydroxy and -diketon moieties.Key words : tetrahydrokurcumin, curcumin, pharmacology, antioxidant
PENGARUH SUSU KEDELAI DOSIS 25 ml/kg BB TERHADAP BIOAVAILABILITAS TEOFILIN PADA TIKUS PUTIH JANTAN Farida Hayati; Arief Rahman Hakim
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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Research has been conducted to study the effect of soya milk 25ml/kg BW per oral toward theophyline bioavailability when given concomittantly in male white rats. The study was done by using of wistar male white rats, weight 200-300 grams, age 3-4 month. The experimental design used was completely randomized design with two groups treatment, which each group test contained five rats. The first group (control) was given single dose pre-treatment of theophyline (25 ml/kg BW, orally), the second group (treatment) was given theophyline and soya milk (25 ml/kg BW, orally) with theophyline 25mg/kg BW. Blood samples were taken periodically from eye vein of rat in the 0,25; 1; 1,5; 3; 5; 6; 8; 10; and 24 hours. Determination of theophyline levels was done with HPLC by using Orcutt and friends method (1977) modified on the 269 nm wavelength. The concentration of theophyline was determined based on a standard curve. Theophyline bioavailability i.e. tmax, Cmax, and AUC0 inf was determined from the concentration to time data . Bioavailability parameters in the first group were tmax 2,36 ± 0,44 hours, Cmax 18,97± 2,06, AUC0 inf 231,48± 34,94 ug.hours/ml and bioavalibility parameters in the second group were tmax 2,08 ± 0,"l 7 hours, Cmax 24,11 ± 1,54, AUC0,nf 210,13±7,25 ug.hours/ml. The results indicated that soya milk was not found to be able to change theophyline bioavailability (P>0,05).
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL KULIT BUAH RAMBUTAN (Nephelium lappaceum L. ) TERHADAP PENANGKAPAN RADIKAL BEBAS DPPH Hady Anshory; Suparmi Suparmi; Arif Setiadi Tamimy
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTRambutan fruits are consumed by people for additional food and medical use. Pericarp oframbutan has been known to have some active compounds such as flavonoid. Many flavonoidsfrom plants are known to have anti radical activity effect or antioxidant. It is very interest todetermine of antioxidant activity from ethanol extract of rambutan pericarp (Nephelium lappaceumL.). Antioxidant activity was carried out spectrophotometry by using DPPH (2,2-diphenyl-1-picrylhydrazyl) as a reagent. The extract and vitamin E (-tocoferol) concentration was made 2, 3,4, 5, and 6 g/ml. The increasing concentration of extract and vitamin E has caused the scavengingof free radical DPPH. The amount of free radical scavenging DPPH was calculated based on itsabsorbance, measured at  521 nm. The result showed that anti radical activity of ethanolic extractof rambutan pericarp (EC50 = 1,62 g/ml) is higher than that of vitamin E (EC50 = 2,91 g/ml).Keywords : Rambutan, antioxidant, free radical DPPH
EKSPLORASI SIFAT FISIKOKIMIA 2-BENZILIDEN-SIKLOHEKSANA-1,3- DION BERDASAR PERHITUNGAN KIMIA KUANTUM SEMIEMPIRIK Enade Perdana Istyastono
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTAromatic cyclic endione has been predicted qualitatively as anticancer agent. 2-Benzylidenecylclohexane-1,3-dione is the simplest aromatic cyclic endione compound. Physicochemistryproperties of 2-benzylidene-cylclohexane-1,3-dione have been explored. The properties wereexplored by semiempirical quantum-chemical calculations using the computational chemistryapproach. Vibrations spectrum of 2-benzylidene-cylclohexane-1,3-dione has been used todetermine the best semiempirical method. The AM1 semiempirical method was found to be themost appropriate method to describe the structure of 2-benzylidene-cylclohexane-1,3-dione andexplore the physicochemistry properties.Keywords : anticancer, physicochemistry, semiempirical quantum-chemical calculation, 2-benzylidene-cylclohexane-1,3-dione.
TERATOGENIC EFFECTS OF BERGAPTEN, A NEW BOTANICAL PESTICIDE, ON FETUSES OF WHITE MICE Almahdy A.
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTLocal white mice were used to evaluate the toxic and teratogenic effects of various dose levels0.0, 0.5, 1.0, and 1.5 mg/kg body weight of Bergapten on fetuses and pups of pregnant females.The oral administration of the different dose levels of Bergapten on days 6-15 of gestation has notproduced any toxic condition and morphological or skeletal changes in fetuses of mice.Key Word : Bergapten, Teratogenicity, mice.
POTENSI KEJADIAN INTERAKSI OBAT PADA PENGGUNAAN OBAT UNTUK PASIEN ANAK YANG DIRAWAT INAP DENGAN DIAGNOSA INFEKSI SALURAN PERNAFASAN DI SALAH SATU RUMAH SAKIT SWASTA DI SURAKARTA Saepudin Saepudin; Suci Hanifah; Wachidah Rahmawati
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTThis research was aimed at knowing potential drug interactions on drug prescribing fortreatment of hospitalized pediatric patients with respiratory tract infection. Research was carriedout at a private hospital in Surakarta and data were collected from medical records of patients werehospitalized during January – December 2005. Potential drug interactions were determinedtheoretically using some literatures on drug interaction. From total 186 patients included in thisresearch, 67.2% were 0-4 years old with common cold was the most diagnosed. There were 52.7%patients receiving 4-6 item of drugs and 76.9% patients were hospitalized during 1-3 days.Potential drug interactions were identified in 30.7% patients with 1.8% and 15.8% of them at level 1and 2 clinical significance, respectively. Statistically, there was a relationship between potentialdrug interactions and length of hospitalization (p = 0.001). Some further investigations(prospectively) are needed to ensure results from this research.Key words : drug interaction, respiratory tract infection, pediatric

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