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INDONESIA
Jurnal Farmasi Klinik Indonesia
Published by Universitas Padjadjaran
ISSN : 23375701     EISSN : 2337 5701     DOI : -
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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
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Indikator Perawatan Pasien: Resep Pasien Degeneratif-Nondegeneratif dan Resep Racikan-Nonracikan di Salah Satu Apotek di Bandung Dika P. Destiani; Ainun M. Nasution; Anita P. Pratama; Elida R. Mujihardianti; Fenadya Rahayu; Michael Michael; Muhammad W. Amrillah; Nida Anistia; Steven A. Pamolango; Theresia R.; Rano K. Sinuraya; Abdurahman R.; Riestya D. Permata
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6989.481 KB) | DOI: 10.15416/ijcp.2018.7.2.134

Abstract

Apotek merupakan salah satu sarana dilakukannya pelayanan kefarmasian oleh seorang apoteker. Dilaporkan bahwa 50% pasien gagal menerima pengobatan secara tepat karena peresepan dan praktik pemberian obat (dispensing) yang tidak sesuai. Apoteker memiliki peran untuk lebih terlibat dalam pelayanan kefarmasian (pharmaceutical care) yang berorientasi pada pasien. Pada penelitian ini dilakukan evaluasi perawatan pasien (patient care) di Apotek Pendidikan Universitas Padjadjaran (Unpad) Kota Bandung, pada bulan Juli–Oktober tahun 2017, dengan menilai beberapa faktor dalam pemberian obat sesuai dengan ketentuan instrumen indikator perawatan pasien dari WHO. Penelitian ini menggunakan rancangan cross-sectional dengan jumlah sampel minimal 20 pasien. Indikator yang digunakan meliputi: lama waktu konsultasi, lama waktu pemberian obat, persen obat yang dapat diserahkan, pelabelan yang benar, dan pengetahuan akan dosis. Hasil penelitian menunjukkan rata-rata waktu pemberian obat 264 detik, persentase obat yang diserahkan 97,18%, persentase obat yang terlabeli dengan benar 100%, dan waktu rata-rata konsultasi 99,03 detik. Indikator pengetahuan pasien mengenai obatnya hanya 17,07% dan waktu konsultasi bervariasi yaitu 10–370 detik, dibandingkan waktu rekomendasi yaitu 60 detik. Tingkat pengetahuan pasien mengenai obat atau dosis hanya 21,17%. Kegiatan pelayanan kefarmasian di Apotek Pendidikan Unpad dapat dinilai dengan menggunakan indikator WHO dan diketahui bahwa pengetahuan pasien akan dosis obat dipengaruhi oleh jenis penyakit yaitu penyakit degeneratif dan nondegeneratif, sedangkan waktu pemberian obat dan pelabelan obat yang benar dipengaruhi oleh jenis resep pasien yaitu resep racikan atau nonracikan. Kecepatan waktu pelayanan untuk pasien nonkonseling perlu ditingkatkan sehingga diharapkan pasien dapat menerima obat dengan cepat. Pengetahuan pasien mengenai terapinya yang masih rendah juga diharapkan dapat meningkat dengan pemberian informasi obat atau konseling.Kata kunci: Indikator pasien, pelayanan kefarmasian, pengetahuan pasien, waktu konsultasi, waktu dispensing, tepat labelPatient Care Indicator: Degenerative-Nondegenerative Patients and Compounded-Non-Compounded Prescription in One of Community Pharmacy in BandungAbstractPharmacy is one of facilities for pharmacist to do a pharmaceutical care. It has been reported that 50% of patients failed to receive a treatment properly because of error in prescription and dispensing practices. Pharmacist has to be more involved in patient-oriented of pharmaceutical care. This study was conducted to evaluate pharmaceutical care in Apotek Pendidikan Universitas Padjadjaran (Unpad) Bandung from July–October in 2017, by assessing several factors in drugs dispensing using WHO patient indicators instrument. This cross-sectional study was conducted with a minimum sample size of 20 patients. The indicators that we used based on WHO assessment were average consultation time, dispensing time, percent of drugs that can be delivered, percent of labeling, and knowledge of dosage. The results showed that the average of consultation time was 99.03 s, average of dispensing time was 264 s, percentage of delivered drug was 97.18%, and 100% of correctly labeled drugs. Patients’ knowledge about their drug was only 17.07%, and consultation time varied from 10 to 370 s, compared with recommended time which is 60 s. Patients’ knowledge about dose was only 21.17%. Pharmaceutical care in Apotek Pendidikan Unpad Bandung could be assessed by WHO indicators and can be seen that patients’ knowledge of drug dose was influenced by type of disease which is degenerative and nondegenerative diseases, while time of drug administration and correct drug labeling was influenced by type of prescription of patients that is prescription of compounded medicine or non-compounded medicine. Pharmacists need to increase their service time so that patients can receive the drug quickly. Low patient’s knowledge is also expected to increase by drug information service and counseling.Keywords: Consultation time, dispensing time, patient indicators, patient knowledge, pharmaceutical care, right label
Evaluasi Penggunaan Obat Antihipertensi pada Pasien Stroke Iskemik di Rumah Sakit Stroke Nasional Bukittinggi Dian A. Juwita; Dedy Almasdy; Tika Hardini
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.454 KB) | DOI: 10.15416/ijcp.2018.7.2.99

Abstract

Obat antihipertensi menjadi salah satu obat yang paling banyak diresepkan pada pasien stroke iskemik. Penatalaksanaan hipertensi yang tidak tepat pada kedaruratan neurovaskular akut dapat meningkatkan risiko kerusakan otak dan saraf. Penggunaan obat antihipertensi harus dievaluasi melalui program evaluasi penggunaan obat (EPO) untuk menjamin penggunaan obat yang rasional. Penelitian ini bertujuan untuk mengkaji kerasionalan/ketepatan penggunaan obat antihipertensi pada pasien stroke iskemik meliputi tepat indikasi, tepat obat, tepat regimen dosis dan tepat pasien. Penelitian ini merupakan penelitian deskriptif retrospektif dengan menggunakan data rekam medis 150 pasien stroke iskemik. Kriteria inklusi penelitian yaitu semua pasien stroke iskemik nonkardioemboli dan tanpa komplikasi yang menerima terapi antihipertensi di Instalasi Rawat Inap (IRNA) Rumah Sakit Stroke Nasional (RSSN) Bukittinggi pada tahun 2016. Evaluasi ketepatan dilakukan secara deskriptif dengan membandingkan data penelitian terhadap literatur. Hasil penelitian menunjukkan ketepatan penggunaan obat antihipertensi yaitu 100% tepat indikasi; 84% tepat obat; 96% tepat dosis; 98% tepat frekuensi; dan 100% tepat pasien. Jenis ketidaktepatan yang paling sering ditemui adalah ketidaktepatan kombinasi obat serta ketidaksesuaian pemilihan obat dengan stage hipertensi yang diderita pasien. Dibutuhkan peran apoteker rumah sakit sebagai bagian dari upaya peningkatan ketepatan penggunaan obat pada pasien stroke.Kata kunci: Antihipertensi, evaluasi penggunaan obat, stroke iskemik, tepat dosis, tepat indikasi, tepat obat Evaluation of Antihypertensive Drug Use on Ischemic Stroke Patients at National Stroke Hospital BukittinggiAbstractAntihypertensive drugs are the most widely prescribed drug for ischemic stroke patients. Inappropriate management of hypertension in acute neurovascular emergencies may increase the risk of brain and nerve damage. Use of antihypertensive drugs should be evaluated through a drug use evaluation program to ensure rational use of drugs. This study aimed to examine the rationale for the use of antihypertensive drugs in patients with ischemic stroke including indications, drugs, dosage regimens and patients. This research was a retrospective descriptive study using medical record data of 150 ischemic stroke patients who met the inclusion criteria, i.e. all non-cardioembolic and uncomplicated ischemic stroke patients receiving antihypertensive therapy in Inpatient Care (IRNA of National Stroke Hospital Bukittinggi (RSSN) in 2016. The evaluation of accuracy was done descriptively by comparing the research data with the literature. The results showed that 100% of medication use was precisely indicated; 84% precise medication; 96% right dose; 98% exact frequency; and 100% precise patient. Inappropriate drug selection compared to the stage of hypertension and incorrect drug combinations were the most common types of inappropriate medications found in this study inaccuracies. It takes the role of hospital pharmacists as part of efforts to improve the accuracy of drug use in stroke patients.Keywords: Antihypertensive, correct dose, drugs use evaluation, ischemic stroke, precise indication, proper drug
Hubungan Penurunan Nilai Densitas Mineral Tulang dengan Kepatuhan Terapi Metilprednisolon Pasien Artritis Reumatoid dan Lupus Eritematosus Sistemik Anisyah Achmad; Bagus P. P. Suryana; Niela Amalia
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2567.377 KB) | DOI: 10.15416/ijcp.2018.7.2.108

Abstract

Metilprednisolon merupakan glukokortikoid yang memiliki efek samping penurunan densitas mineral tulang (DMT). Tingkat kepatuhan berhubungan dengan terjadinya efek. Penelitian ini bertujuan untuk mengetahui hubungan penurunan nilai DMT dengan kepatuhan terapi metilprednisolon pada pasien artritis reumatoid dan lupus eritematosus sistemik. Penelitian ini dilakukan pada 43 pasien di Poliklinik Rheumatologi RSUD dr. Saiful Anwar Malang pada bulan Desember 2016–Januari 2017 dan termasuk penelitian deskriptif noneksperimental dengan analisis kualitatif dan kuantitatif menggunakan metode cross-sectional. Data diambil dari rekam medis pasien dan wawancara. Kriteria inklusi pada penelitian ini adalah perempuan berusia 31–50 tahun, menggunakan terapi metilprednisolon minimal selama 3 bulan serta memiliki data DMT. Kriteria eksklusi adalah menopause, riwayat fraktur tulang, merokok, mengonsumsi alkohol, sindrom cushing, hipertiroidisme, hiperparatiroidisme, gangguan kelenjar pituitari, dan osteoartritis serta mengonsumsi obat bifosfonat, heparin, anti-konvulsan, dan thiazid. Analisis data menggunakan uji korelasi Pearson dan regresi linier. Terdapat hubungan antara kepatuhan dengan area DMT Spine-L1 (r= –0,313; p=0,041), Spine-L2 (r= –0,349; p=0,022), Spine-L3 (r= –0,375; p=0,013), dan total spine (r = -0,380; p = 0,012). Metilprednisolon sensitif pada jaringan tulang trabekular yang menyusun area lumbar spine dibandingkan tulang kortikal. Hubungan rendah (r) antara tingkat kepatuhan dan DMT disebabkan sosial ekonomi, perawatan kesehatan, karakteristik penyakit, dan genetik. Kepatuhan terapi metilprednisolon menurunkan nilai DMT (lumbar spine) yang berakibat meningkatkan osteoporosis.Kata kunci: Artritis reumatoid, densitas mineral tulang, eritematosus sistemik, kepatuhan, lupus metilprednisolon The Relationship of Lowering the Values of Bone Mineral Density in Methylprednisolone Medication Adherence on Rheumatoid Arthritis and Systemic Lupus Erythematosus PatientsAbstractMethylprednisolone is a glucocorticoid which has a side effect of decreasing bone mineral density (DMT). The degree of compliance relates to the occurrence of effects. The objective of this study was to investigate the association of DMT impairment with adherence to methylprednisolone therapy in patients with rheumatoid arthritis (AR) and systemic lupus erythematosus (LES). The research was conducted to 43 patients in Rheumatology Polyclinic of dr. Saiful Anwar (RSSA) Malang. The study was conducted in December 2016–January 2017 and included nonexperimental description with qualitative and quantitative analysis using cross sectional method. The data were taken from the patient’s medical record and interview. The inclusion criteria in this research were women, aged 31–50 years, using metilprednisolon therapy for at least three months and have mineral bone density data. Exclusion criteria were menopause, history of bone fracture, smoking, alcohol consumption, cushing syndrome, hyperthyroidism, hyperparathyroidism, pituitary gland disorders, and osteoarthritis and taking drugs bisphosphonates, heparin, anti-convulsants, and thiazid. Data analysis used person correlation and linear regression. There was a significant correlation between adherence to the Spine-L1 DMT area (r= –0.313; p=0.041), Spine-L2 (r= –0.349; p=0.022), Spine-L3 (r = –0.375; p=0.013), and total spine (r= –0.380; p=0.012). Methylprednisolone is sensitive to trabecular bone tissue that makes up the lumbar spine area compared to cortical bone. The low association (r) between adherence and DMT is due to socioeconomic, health care, disease characteristics, and genetics. Compliance of methylprednisolone therapy decreases the value of DMT (lumbar spine) which increased in osteoporosis.Keywords: Bone mineral density, medication adherence, methylprednisolone, reumathoid arthritis, systemic lupus eythematosus
Efektivitas dan Risiko Toksisitas Aminofilin Intravena pada Pengobatan Awal Serangan Asma Amelia Lorensia; Zullies Ikawati; Tri M. Andayani; Rivan V. Suryadinata; Khaula A. A. Hantoro; Lisma D. Firanita
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.49 KB) | DOI: 10.15416/ijcp.2018.7.2.78

Abstract

Asma merupakan penyakit inflamasi kronis pada saluran pernafasan yang mempunyai prevalensi global yang cukup besar. Perburukan penyakit asma berupa serangan asma yang menyebabkan peningkatan gejala asma dan penurunan fungsi paru secara progresif. Salah satu obat asma yang masih sering digunakan di Indonesia adalah aminofilin intravena. Aminofilin merupakan obat dengan rentang terapi sempit yang berisiko menyebabkan toksisitas obat, namun data perbandingan keuntungan efektivitas dan keamanan obat tersebut belum memadai. Penelitian ini bertujuan untuk mengetahui efektivitas aminofilin intravena pada pengobatan awal serangan asma berupa perbaikan gejala asma dan kejadian toksisitas terkait gejala yang muncul dan kadar teofilin dalam darah di suatu rumah sakit di Surabaya, Indonesia. Penelitian ini menggunakan metode pra-eksperimental yang dilaksanakan sejak 2014 hingga 2016. Sebanyak 27 pasien terlibat dalam penelitian ini. Terapi yang diberikan adalah aminofilin intravena selama satu jam. Metode sampling yang digunakan adalah consecutive sampling dengan teknik analisis deskriptif dan jum. Semua subjek penelitian menunjukkan perbaikan gejala serangan asma dengan terapi aminofilin intravena selama satu jam, dan tidak ada yang mengalami toksisitas karena kadar teofilin dalam darah di bawah rentang terapi. Aminofilin masih efektif dalam mengurangi gejala pada serangan asma dan tidak menunjukkan risiko toksisitas.Kata kunci: Aminofilin, efektivitas, serangan asma, toksisitas Effectiveness and Toxicity Risk of Intravenous Aminophylline in Exacerbation Asthma TreatmentAbstractAsthma is a chronic inflammatory disease in the respiratory tract that has a considerable global prevalence. The worsening of asthma is an asthma attack that causes asthma symptoms to increase and decreased lung function progressively. One of the most commonly used asthma medications in Indonesia is intravenous aminophylline. Aminophylline is a drug with a narrow range of therapies that is at risk of causing drug toxicity, but the comparative data on the efficacy and safety benefits of the drug are inadequate. This study aimed to determine the effectiveness of aminophylline intravenously in the early treatment of asthma attacks in the form of improvements in asthma symptoms and toxicity events related to the symptoms that appear and blood theophylline levels in a hospital in Surabaya, Indonesia. This study used a pre-experimental method which was carried out from 2014 to 2016. A total of twenty seven patients were involved in the study. The therapy given was aminophylline intravenously for one hour. The sampling method used was consecutive sampling with descriptive analysis technique. All subjects showed improved symptoms of asthma attacks with intravenous aminophylline therapy for one hour, and none had toxicity due to theophylline levels in the blood below the therapeutic range. Aminophylline is still effective in reducing symptoms in asthma attacks and does not indicate the risk of toxicity.Keywords: Aminophylline, asthma attack, effectiveness, toxicity
Imunoekspresi Poly (ADP-Ribose) Polymerase sebagai Petanda Kemoresisten pada Karsinoma Ovarium Retno Westiningrum; Hermin A. Usman; Herry Yulianti; Bethy S. Hernowo
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2794.834 KB) | DOI: 10.15416/ijcp.2018.7.2.115

Abstract

Karsinoma ovarium merupakan keganasan kelima terbanyak dan penyebab kematian ginekologi pertama di dunia. Kemoterapi merupakan modalitas terapi utama karsinoma ovarium dengan stadium lanjut setelah dilakukan pembedahan. Poly (ADP-Ribose) Polymerase (PARP) dan B cell Lymphoma-2 (Bcl-2) merupakan petanda imunohistokimia yang berfungsi dalam proses DNA repair dan anti-apoptosis yang merupakan bagian dari lingkaran mekanisme kerja regimen kemoterapi pada sel tumor. Oleh karena itu dua mekanisme tersebut dianggap memegang peranan penting terhadap terjadinya resisten kemoterapi bahkan rekurensi. Tujuan penelitian ini adalah melihat hubungan imunoekspresi PARP dan Bcl-2 dengan respons kemoterapi pada karsinoma ovarium. Penelitian ini menggunakan desain analisis observasi secara potong lintang dengan menggunakan blok parafin pasien yang didiagnosis sebagai karsinoma ovarium selama periode tahun 2012−2015 di Departemen Patologi Anatomi RSUP Dr Hasan Sadikin Bandung. Jumlah sampel sebanyak 58 kasus yang terdiri atas 30 kasus kemoterapi sensitif dan 28 kasus kemoterapi resisten, keseluruhan sampel dilakukan pulasan imunohistokimia PARP dan Bcl-2. Analisis data menggunakan uji Chi-Square dengan taraf signifikansi 5%. Hasil dari penelitian ini adalah 60% sampel terekspresi PARP kuat dengan proporsi terbesar pada kelompok resisten (p=0,001) dan 74% sampel terekspresi Bcl-2 lemah dengan proporsi sama pada tiap kelompok respon kemoterapi (p=0,45). Respons kemoterapi sangat dipengaruhi oleh proses DNA repair yang dapat dinilai dengan pemeriksaan imunoekspresi PARP. Semakin tinggi imunoekspresi PARP maka semakin tinggi kemampuan DNA repair sehingga semakin tinggi kemungkinan kemoterapi resisten.Kata kunci: Bcl-2, karsinoma ovarium, kemoterapi, PARP Poly (ADP-Ribose) Polymerase Immunoexpression as Chemoresistance Marker in Ovarian CarcinomaAbstractEpithelial ovarian cancer (EOC) is the fifth most common cancer and the main cause of gynecological cancer death worldwide. Chemotherapy is the main therapy in advanced stage of EOC. Poly (ADP-Ribose) Polymerase (PARP) dan B cell Lymphoma-2 (Bcl-2) are immunohistochemistry markers that represent influential factors in chemotherapy response which have roles in DNA repair and anti-apoptosis. The aim of this study was to review the correlation between PARP and Bcl-2 expression with chemotherapy response in EOC. This research was performed as analytic-observational with cross-sectional design using paraffin block of patients diagnosed as EOC in 2012–2015 at Anatomical Pathology Department, Hasan Sadikin Hospital Bandung. Total sample was 58 cases which were divided into chemotherapy sensitive and resistant. All samples were stained by immunohistochemistry PARP and Bcl-2 and analysed using Chi-Square test with significant level of 5%. The results of this study showed that 60% of all samples have strong PARP expression whereas the largest proportion is in chemotherapy resistant group (p=0.001) and 74% of all samples have weak Bcl-2 expression in each group (p=0.45). The conclusion of this study in chemotherapy response was influenced by PARP. Higher PARP immunoexpression showed higher tumour cell ability to repair DNA and higher chemotherapy resistance.Keywords: Bcl-2, chemotherapy, EOC, PARP
Evaluasi Penggunaan Antibiotik dan Profil Kuman pada Seksio Sesarea di Rumah Sakit Umum Daerah Kabupaten Pasuruan Rika Yulia; Fauna Herawati; Abdul K. Jaelani; Wirda Anggraini
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.91 KB) | DOI: 10.15416/ijcp.2018.7.2.69

Abstract

Infeksi Luka Operasi (ILO) adalah salah satu komplikasi pembedahan yang paling umum terjadi di dunia, terutama di negara berkembang. Penggunaan antibiotik profilaksis sebelum operasi yang tepat dapat mengurangi ILO. Penelitian ini bertujuan untuk mengetahui profil penggunaan antibiotik dan kesesuaian penggunaan antibiotik pada seksio sesarea dengan peta kuman rumah sakit, Pedoman Penggunaan Antibiotik (PPAB) 2016, Formularium Rumah Sakit (RS), Formularium Nasional (Fornas), serta mengidentifikasi profil kuman penyebab ILO pada luka pasien. Metode penelitian menggunakan metode cohort prospective melalui penelusuran data terhadap rekam medik pasien yang menjalani tindakan operasi seksio sesarea di salah satu rumah sakit di Kabupaten Pasuruan periode Maret–Mei 2017, yaitu data penggunaan antibiotik (jenis antibiotik, dosis, waktu pemberian) dan data peta kuman bulan Januari–Maret 2017 terkait resistensi antibiotik. Analisis data berupa deskripsi profil penggunaan antibiotik, kesesuaian penggunaan antibiotik pada pasien seksio sesarea dengan pedoman, dan profil kuman penyebab ILO. Hasil yang diperoleh dari penelitian ini menunjukkan bahwa penggunaan antibiotik pada pasien seksio sesarea adalah ampisilin/sulbaktam 37%, sefuroksim 34%, seftriakson 24%, sefazolin 5%, metronidazol 1%, dan gentamisin 1%. Kesesuaian berdasarkan jenis antibiotik secara berturut-turut 5% berdasarkan PPAB, 100% berdasarkan Formularium RS dan 63% berdasarkan Fornas. Hal ini disebabkan oleh pola sensitivitas sefazolin berdasarkan peta kuman bulan Januari–Maret 2017 semakin menurun. Kesesuaian berdasarkan dosis antibiotik 100% sesuai berdasarkan PPAB, Formularium RS dan Fornas. Kesesuaian berdasarkan dosis antibiotik dan waktu pemberian 92% sesuai berdasarkan PPAB. Kuman yang ditemukan pada luka pasien adalah bakteri Hafnia alvei.Kata kunci: Antibiotik profilaksis, Infeksi Luka Operasi, seksio sesarea Evaluation of Antibiotics Use and Bacteria Profile of Caesarean Section at Regional General Hospital, PasuruanAbstractSurgical Site Infection (SSI) is one of the most common surgical complications in the world, especially in developing countries. Proper use of prophylaxis antibiotics in appropriate intraoperative procedures may reduce SSI. The aim of this study was to determine the profile of antibiotic used and the adherence of antibiotic in caesarean section to Hospital Guideline 2016, Hospital Formulary, National Formulary, bacteria profile that cause SSI on the patient’s wound. Method used in this study was cohort prospective study design using record data of patients who underwent caesarean section surgery at Regional General Hospital of Pasuruan from March–May 2017, i.e. antibiotics usage data (type, dosage and time of delivery) and microbial pattern data about antibiotic resistance from January–March 2017. Data analysis was description of the profile of antibiotic use, adherence use of antibiotic of caesarean section inpatients to the guidelines, and profile of bacteria that cause SSI. The results showed that the use of antibiotics in caesarean section patients was ampicillin/sulbactam 37%, cefuroxime 34%, ceftriaxone 24%, cefazolin 5%, metronidazole 1%, and gentamycin 1%. Adherence by type of antibiotics was 5% based on Hospital Guideline, 100% based on Hospital Formulary and 63% based on National Formulary. This was due to a decrease of cefazolin sensitivity pattern from 20% to 0% in January–March 2017 period. Adherence of antibiotic dosage was 100% based on Hospital Guideline, Hospital Formulary and National Formulary. Adherence of time of delivery 92% was based on Hospital Guideline. Bacteria found in the wounds of patients was Hafnia alvei.Keywords: Caesarean section, prophylaxis antibiotic, surgical site infection

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