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INDONESIA
Jurnal Farmasi Klinik Indonesia
Published by Universitas Padjadjaran
ISSN : 23375701     EISSN : 2337 5701     DOI : -
Core Subject :
Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
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Articles 13 Documents
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Search results for , issue "Vol 7, No 3 (2018)" : 13 Documents clear
Kajian Penggunaan, Ketepatan, dan Biaya Antibiotik pada Pasien Rawat Inap Anak di Sebuah Rumah Sakit Umum di Surabaya Silvia Monica; Sylvi Irawati; Eko Setiawan
Indonesian Journal of Clinical Pharmacy Vol 7, No 3 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.455 KB) | DOI: 10.15416/ijcp.2018.7.3.194

Abstract

Ketepatan penggunaan antibiotik merupakan salah satu aspek penting untuk memastikan efektivitas dan keamanan terapi pada semua kelompok pasien, terutama kelompok pasien dengan perbedaan fisiologi dan profil farmakokinetika. Penelitian ini bertujuan untuk mengkaji penggunaan, ketepatan, dan biaya antibiotik pada bangsal rawat inap anak selama periode November–Desember 2015. Metode pengumpulan data pada penelitian ini adalah observasi yang dilakukan secara prospektif terhadap seluruh data rekam medis pasien rawat inap anak yang mendapatkan antibiotik selama periode pengambilan data. Data pasien rawat inap anak yang mendapatkan antibiotik dengan indikasi profilaksis sebelum pembedahan, menghendaki pulang paksa, dan memerlukan perawatan khusus pada saat pengambilan data dieksklusi dari penelitian. Total terdapat 109 rekam medis pasien yang memenuhi kriteria inklusi dan eksklusi. Sebesar 82 pasien (75,23%) pada penelitian ini berusia 1–24 bulan. Terdapat 5 pasien (4,59%) dengan diagnosis keluar noninfeksi dan tidak memiliki tanda infeksi yang menerima antibiotik. Tidak terdapat pasien yang mendapatkan kultur bakteri. Golongan antibiotik yang paling banyak digunakan adalah sefalosporin generasi III yaitu sebesar 114 antibiotik (90,48%), dan sebanyak 63 antibiotik (55,26%) di antaranya adalah seftriakson. Penggunaan antibiotik pada 21 pasien (45,65%) dinyatakan sesuai dosis, pada 19 pasien (41,30%) hanya sesuai dosis dan frekuensi, serta pada 6 pasien diklasifikasikan sebagai tidak ada yang sesuai. Biaya rata-rata antibiotik per pasien pada penelitian ini adalah sebesar Rp209.731,72. Penggunaan antibiotik pada pasien rawat inap anak pada rumah sakit tempat pengambilan data perlu dioptimalkan ketepatannya. Kultur bakteri dan uji sensitivitas perlu diupayakan di rumah sakit tempat pengambilan data sebagai upaya penjaminan ketepatan antibiotik.Kata kunci: Antibiotik, pediatrik, review penggunaan obat Review of the Utilization, Appropriateness, and Cost of Antibiotics among Paediatric Inpatients in a Public Hospital in SurabayaAbstractAn appropriate utilization of antibiotics is one of important aspects to assure treatment effectiveness and safety in all patient groups, especially in patients with distinctive physiology and pharmacokinetic profile. This study aimed to assess the utilization, appropriateness and cost of antibiotics administered in a pediatric hospital ward during November–December 2015. Method used to collect the data was observation conducted prospectively towards all medical records of paediatric inpatients receiving antibiotics during the study period. Medical records of patients receiving prophylaxis antibiotics before surgery, patients discharged against medical advice, and patients suddenly needed medical treatment in a special ward were excluded from the study. Overall, a total of 109 medical records met inclusion and exclusion criteria, in which 82 (75.23%) patients’ age ranged from 1 month to 2 years. There were 5 (4.59%) patients with non-infectious diagnoses and no signs of infection receiving antibiotics. No patients were tested for a microbial culture. The most utilized antibiotic class was the 3rd generation of cephalosporins (114 antibiotics, 90.48%); 63 (55.26%) of which was ceftriaxone. The utilization of antibiotics in 21 (45.65%) patients was considered dose appropriate, in 19 (41.30%) patients were dose-frequency appropriate and in 6 patients was classified as none appropriate. The mean of the cost of antibiotic per patient was IDR 209,731.72. There is a need to optimalize the appropriateness of antibiotic utilization in hospitalized pediatrics at the study hospital. Microbial culture and sensitivity tests would plausibly be one of preliminary steps to guard the appropriateness of antibiotic utilization.Keywords: Antibiotics, drug utilization review, paediatrics
Profil Mean Arterial Pressure dan Tekanan Darah pada Pasien Hipertensi Krisis dengan Kombinasi Amlodipin Ria Angelina; Nurmainah Nurmainah; Robiyanto Robiyanto
Indonesian Journal of Clinical Pharmacy Vol 7, No 3 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (523.582 KB) | DOI: 10.15416/ijcp.2018.7.3.172

Abstract

Berdasarkan pedoman pengobatan hipertensi krisis, pengobatan hipertensi emergensi menggunakan antihipertensi parenteral sedangkan hipertensi urgensi menggunakan antihipertensi oral. Tujuannya agar tercapai penurunan Mean Arterial Pressure (MAP) di bawah 25% dan tekanan darah sistolik/diastolik (TDS/TDD) di bawah atau sama dengan 160/100 mmHg. Penelitian ini bertujuan untuk mendeskripsikan penurunan MAP dan TDS/TDD setelah 24 jam pemberian amlodipin oral dengan berbagai kombinasi pada pasien hipertensi krisis. Penelitian ini merupakan penelitian observasional dengan rancangan potong lintang (cross-sectional) yang bersifat deskriptif. Pengumpulan data dilakukan secara retrospektif berdasarkan data rekam medis pasien hipertensi krisis rawat inap di RSUD Sultan Syarif Mohamad Alkadrie Kota Pontianak periode Januari 2016–Desember 2017. Sampel yang diperoleh sebanyak 38 pasien. Hasil penelitian menunjukkan bahwa pasien hipertensi emergensi yang menggunakan amlodipin secara oral dengan kombinasi antihipertensi lainnya memiliki nilai MAP setelah 24 jam sebesar 24% dan beberapa pasien hipertensi emergensi menunjukkan pencapaian MAP-nya sebesar 32%. Namun demikian, penurunan TDS/TDD setelah 24 jam mencapai di bawah atau sama dengan 160/100 mmHg. Penggunaan amlodipin oral dengan berbagai kombinasi terapi antihipertensi lainnya pada pasien hipertensi urgensi menunjukkan pencapaian MAP berkisar 20–23%. Sementara itu, TDS/TDD setelah 24 jam mencapai sekitar dan di bawah 160/100 mmHg. Penggunaan amlodipin secara oral dengan kombinasi antihipertensi lainnya pada pasien hipertensi emergensi belum mampu menunjukkan penurunan MAP sesuai yang diinginkan. Di sisi lain, penanganan hipertensi urgensi dengan menggunakan amlodipin oral dengan berbagai kombinasi terapi antihipertensi lainnya menunjukkan pencapaian penurunan MAP sesuai dengan pedoman pengobatan hipertensi krisis.Kata kunci: Amlodipin, hipertensi krisis, mean arterial pressure, tekanan darah Mean Arterial Pressure and Blood Pressure Profile in Hypertensive Crises Patients with Amlodipine Therapy CombinationAbstractBased on treatment guidelines of crisis hypertension, emergency hypertensive treatment uses parenteral antihypertensive whereas urgency hypertensive uses oral antihypertensive. The goal is to achieve a drop in Mean Arterial Pressure (MAP) below 25% and systolic/diastolic blood pressure (SBP/DBP) below or equal to 160/100 mmHg. This study aimed to describe the decrease in MAP and SBP/DBP after 24 hours of oral amlodipine administration with various combinations in patients with crisis hypertension. This research was an observational research with cross-sectional design which was descriptive. Data collection was done retrospectively based on medical record data of hypertensive crisis patients that hospitalized at RSUD Sultan Syarif Mohamad Alkadrie Pontianak City from January 2016 until December 2017. The samples obtained were 38 patients. Results from the study showed that emergency hypertension patients who used oral amlodipine with other antihypertensive combinations had 24-hour MAP values of 24% and some emergency hypertension patients showed a MAP attainment of 32% with decreased SBP/DBP after 24 hours reached under 160/100 mmHg. The use of oral amlodipine amlodipine with other antihypertensive combinations in urgency hypertensive patients showed an achievement of 20–23% reduction in MAP with decreased SBP/DBP after 24 hours under 160/100 mmHg. The use of oral amlodipine with other antihypertensive combinations in emergency hypertensive patients did not show a desirable reduction in MAP. Treatment of urgency hypertensive by using oral amlodipine with various combinations of other antihypertensive therapies showed a decrease in MAP according to crisis hypertension treatment guidelines.Keywords: Amlodipine, blood pressure, hypertensive crises, mean arterial pressure
Efek Perseptif Penggunaan Kombinasi Antidiabetes Oral-Insulin pada Pasien Diabetes Melitus Tipe 2 di Kota Pontianak dan Sekitarnya Winona Madelina; Eka K. Untari; Esy Nansy
Indonesian Journal of Clinical Pharmacy Vol 7, No 3 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.632 KB) | DOI: 10.15416/ijcp.2018.7.3.209

Abstract

Penggunaan antidiabetes oral dan insulin yang benar dapat menimbulkan efek perseptif positif akibat terkontrolnya kadar gula darah dengan baik sehingga gejala klinik diabetes dapat berkurang atau tidak ada sama sekali. Penelitian ini bertujuan untuk mendeskripsikan lama penggunaan kombinasi antidiabetes oral-insulin dengan efek perseptif yang dirasakan. Penelitian ini merupakan penelitian observasional dengan rancangan penelitian potong lintang (cross-sectional) yang bersifat deskriptif. Selama penelitian diperoleh 23 subjek penelitian yang memenuhi kriteria inklusi. Pengambilan data dan wawancara dilakukan pada bulan November–Desember tahun 2016 di Kota Pontianak dan sekitarnya. Penelitian ini menunjukkan bahwa subjek penelitian sebagian besar wanita (73,9%), usia terbanyak pada 55–64 tahun (43,47%), pendidikan terakhir yakni Sekolah Dasar (34,7%), serta pekerjaan ibu rumah tangga (43,4%) dengan lama penyakit ≥10 tahun (52%), dan memiliki komorbid (86.9%). Kombinasi long-acting dan antidiabetes oral (ADO) golongan biguanid paling banyak digunakan (39,13%). Lama penggunaan kombinasi antidiabetes oral-insulin sebagian besar subjek penelitian adalah ≥6 bulan (60,87%). Empat belas subjek merasakan efek perseptif (60,87%); 8 dari 14 subjek (57,14%) merasakan berkurangnya rasa lemas yang merupakan jenis efek perseptif, dan 4 subjek (28,57%) subjek merasakan adanya efek samping perseptif.Kata kunci: Diabetes melitus tipe 2, efek perseptif, kombinasi antidiabetes oral-insulin Perceptive Effect of Combination Use of Oral Antidiabetic-Insulin in Type 2 Diabetes Mellitus Patients in Pontianak City and Surrounding AreasAbstractThe use of oral and insulin antidiabetic is suspected causing a positive perceptive effect due to controlled blood sugar levels, thus the clinical symptoms of diabetes can be reduced. The study was aimed to describe the term of combination use of oral antidiabetic and insulin with perceptive effect. This research was an observational-descriptive study using cross-sectional design. Interview and data were collected from November–Desember 2016 in Pontianak City and its surrounding areas. During the research, 23 subjects were eligible for inclusion criteria of the study. This study showed that the subjects were mostly women (73.9%), dominantly aged 55–64 years (43.47%) and took the last education in elementary school (34.7%). The occupation of most subjects are housewives (43.4%), most of them had period of disease ≥10 years (52%) and had comorbid (86.9%). About 39.13% subjects mostly used combination of long-acting type insulin and biguanide class oral antidiabetic. The longest term of oral antidiabetic-insulin use was ≥6 months (60.86%). A total of 14 subjects felt perceptive effects (60.87%), of which 8 subjects (57.14%) had a lesser feeling of weakness, which is one of perceptive effects, and 4 subjects (28.57%) experienced side effect perceptively.Keywords: Combination of oral antidiabetic-insulin, perceptive effects, type 2 diabetes mellitus

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