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Medula
Published by Universitas Halu Oleo
ISSN : 23391006     EISSN : 24430218     DOI : http://dx.doi.org/10.33772/medula
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
MEDULA mengundang kontribusi bagi penelitian original dan fundamental pada bidang kesehatan sebagai sebuah artikel yang melewati proses review.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 3, No 1 (2015)" : 6 Documents clear
Bioaktifitas Antibakteri Ekstrak Etanol Teripang Pasir (Holothuria scabra) terhadap Pertumbuhan Klebsiella pneumoniae Secara In Vitro Fifit Ervitha; Sulastrianah Sulastrianah; Indria Hafizah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 1 (2015)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (397.561 KB) | DOI: 10.46496/medula.v3i1.2538

Abstract

Holothuria scabra is  one of the biota that commonly found in Southeast Sulawesi waters and traditionally use as a source food and medicine by local tribe. They also harvesting this species for exported to several countrywith high demand.  Even this species have commmercially beneficience, but there is lack of publication about the bioactivity, especially H. Scabra derived from southeast Sulawesi. This study aims to determine secunder metabolite that contain in the extractand to examine antibacterial bioactivity of H. scabra ethanol extract againstKlebsiellapneumoniae by defining the Minimum Inhibitory Consentration. The method using an experimental with post test onlycontrol group design. The extraction is using maseration method and the extract then  diluted and divided intoten concentration 100%, 50%, 25%, 12,5%, 6,25%, 3,125%, 1,56%, 0,78%, 0,39%, and 0,19%. The secunder metabolite was determined by using TLC and the MIC was determined by using dilution method. All consentration.As the result, TLC test showing positif result for alcaloid and triterpenoid and the nutrient broth starting to show no turbidity in concetration 0,78%. The conclusion of this study is ethanol extract of H. Scabra contain alkaloid and triterpenoid as secunder metabolite and the MIC was in 0,78% concentration.Keywords: Holothuria scabra, Klebsiella pneumoniae,  MIC, alkaloid, terpenoid
Analisis Faktor Determinan Proksi Kejadian Hipertensi di Poliklinik Interna BLUD RSU Provinsi Sulawesi Tenggara La Ode Alfariki
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 1 (2015)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.538 KB) | DOI: 10.46496/medula.v3i1.2539

Abstract

Hypertension represent the serious and big problem in all the world. From other side because prevalensi which high enough that is 19,7 % and tend to increase a period of/to to come, also because high ferocity storey;level in the form of permanent handicap and sudden death. Hypertension disease of Regency. hypertension in BLUD General Hospital South East Sulawesi Province that in 2008 the number of new visits to the outpatient hypertension as many as 1672 case, as many as 1758 case in 2009 and in 2010 as many as 1789 case. This study aims to analyze the determinants proxy of occurence hypertension in BLUD general hospitals South East Sulawesi Province. This research have the character of the observasional with the device [of] case study manage the (Case Control Study), where case is hypertension patient, is control the  non patient hipertensi.Uji used by Odds Ratio and regresi logistics with the value ά= 0,05. Result of study show there are relation which signifikan to hypertension by family history OR = 6.84 95% CI (3.92 to 11.94), obesity OR = 6.32 95% CI (3.64 to 10.96), consumption of salted fish OR = 9.52 95% CI (5.35 to 16.95), physical activity OR = 8.07 95% CI (4.60 to 14.14), smoking OR = 8.19 95% CI (4.60 to 14.59), stress OR = 5.18 95% CI (3.38 to 9.96), diet OR = 5.44 95% CI (3.12 to 9.50), area of residence OR = 1.53 CI 95% (0.92 to 2.55), on multivariate analysis, consumption of salted fish is a proxy determinant of the incidence of hypertension. Advice need for society to control the risk factors for hypertension by controlling salt consumption, smoking, obesity, regular physical activity, leading a healthy lifestyle, diet.Keywords :  hypertension occurence, family history, obesity, consumption of salted fish, physical activity, smoking, stress, diet, area of residence.
Uji Aktivitas Antibakteri Ekstrak Metanol Rumput Laut (Kappaphycus alvarezii) pada Berbagai Tingkat Konsentrasi terhadap Pertumbuhan Bakteri Streptococcus mutans Agus Saifuddin; Sapto Raharjo; Amiruddin Eso
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 1 (2015)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.821 KB) | DOI: 10.46496/medula.v3i1.2541

Abstract

Red algae Kappaphycus alvarezii contain flavonoids compound which has activity as an anti bacterial. This study aims to determine the difference of inhibition zone of the growth of Streptococcus mutans bacteria by seaweed methanol extract (K. alvarezii) at each concentrations. This research was conducted by post–test only design (one-shot case study) with a variable treatment of the seaweed methanol extract (K. alvarezii) against S. mutans. Extracts were then divided into 7 concentration of 5%, 25%, 50%, 65%, 75%, 85%, and 95%. Data were analyzed to determine the difference of inhibition zone seen from the ANOVA test (analysis of varience) followed by a post hoc test. The results of the bivariate analysis showed there were no difference of inhibition zone of the growth of S. mutans bacteria by seaweed methanol extract of K. alvarezii at the concentration of 65%, 75%, 85%, and 95% (p = 0,143). This research concluded that there were no defference of inhibition zone of the growth of S. mutans bacteria by seaweed methanol extract of K. alvarezii.Keywords : Kappaphycus alvarezii, Streptococcus mutans
Pengaruh Kadar Gula Darah terhadap Kejadian Reinfark dan Kematian pada Penderita Sindroma Koroner Akut Jamaludin Jamaludin; Zaenab Djafar
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 1 (2015)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.397 KB) | DOI: 10.46496/medula.v3i1.2540

Abstract

Recent decades data relates between admission hyperglycemia and mortality that increase among acute coronary syndrome(ACS) patients. Aim  of study is to assess relationship between hyperglycemia and Cardiac Event, i.e. death, reinfarction among ACS patients. This is a prospective cohort study, which was held on March to April 2014 among 83 ACS patients in CVCU Wahodin Sudorohusodo Hospital. Patients was grouped into two groups, hyperglycemic ACS group and normoglycemic one. Reinfarction and death events at each group was observed within first 30 days after infarction. In this study, it found death and reinfarction events were higher in hyperglycemic group than in normoglycemic group (22 vs 4, RR = 3.7, p=0.026 for death event, and 14 vs 1, RR =8.7, p=0.03 for reinfarction). Conclusion of this study was hyperglycemia is related to reinfartion and death events among ACS patients.Keywords: Acute Coronary Syndrome, Hyperglycemia, Reinfarction, Death
Uji Daya Hambat Ekstrak Etanol Bintang Laut Bertanduk (Protoreaster nodosus) terhadap Bakteri Streptococcus sp. dan Candida albicans Indria Hafizah; Sulastrianah Sulastrianah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 1 (2015)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.184 KB) | DOI: 10.46496/medula.v3i1.2536

Abstract

Starfish is a marine biota that have potency for used in human health. Protoreaster nodosus is species of starfish that commonly found in water of southeast Sulawesi and not widely used by local community. The aim of this study is to find out bioactive compound and to examine the antibacterial and antifungal bioactivity ethanol exract of Protoreaster nodosus. Thin Layer Chromatography (TLC) is used in bioactive compound assay and disk diffussion method is used to examine antibacterial and antifungal activity. Ethanol extract of Protoreaster nodosus is diluted into 2000 ppm, 4000 ppm, 8000 ppm, 16.000ppm and 32.000 ppm. As the result result of this study, ethanol extract of Protoreaster nodosus are positively containing alkaloid, steroid, saponin, flavonoid and tannin. The diameter of clear zone of disk containing extract in nutrient agar with Streptococcus sp are  4,4 mm, 5,4 mm, 6,7 mm, 9,4 mm dan 11,4 mm, consecutively. The diameter of clear zone of disk containing extract in potato dextrose agar with Candida albicans are 6,6 mm, 9,15 mm, 11,5 mm, 13,95 mm and 20,7 mm, consecutively. In the conclusion, ethanol extract of Protoreaster nodosus from Southeast Sulawesi containing alkaloid, steroid, saponin, flavonoid and tannin. The Antibacterial activity is strong in concentration of 32.000 ppm and the antifungal activity is strong in 32.000  ppm, 16.000 ppm, 8.000 ppm, 4000 ppm concentration. Keywords: Protoreaster nodosus, antibacterial activity, antifungal activity Streptococcus sp, Candida albicans, secondary metabolite
Uji Aktivitas Antioksidan Mikroalga Air Tawar Rio Kristian; Sapto Raharjo; Sulastrianah Sulastrianah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 1 (2015)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.1 KB) | DOI: 10.46496/medula.v3i1.2537

Abstract

Cell or tissue damage due to oxidative stress can be slowed by giving antioxidants. Antioxidants are vital substances that may help protect the body against free radicals by neutralizing or mitigate negative impacts. The human body is naturally equipped antioxidant defenses. but these antioxidants can not completely prevent cell damage. Body still requires antioxidants from the outside. The purpose of this study was to determine the antioxidant potential of microalgae species in freshwater.This research is a descriptive study of the identification of species of freshwater microalgae samples taken with a microscope and testing of extracts from freshwater microalgae species of antioxidant activity using DPPH method. Microalgae extract as much 2,25ml then homogenized with DPPH as 0,75ml in containers with a volume of 3ml. The containers are then incubated for 30 minutes in a dark room. Furthermore, the container is inserted into the spectrophotometer to read absorbance at 519nm wavelength. Results absorbance at the input curves to obtain IC50 values.The results that have identified three species of freshwater microalgae namely Navicula sp., Oscillatoria sp., And Carteria sp. From all three species showed strong inhibition against DPPH with IC50 values sequentially 41.304 ppm, 23.401 ppm and 51.433 ppm. The conclusions of this study are species of freshwater microalgae are obtained, namely Navicula sp., Oscilatoria sp., And Carteria sp. has potential antioxidant activityKeywords: Microalgae, antioxidant, DPPH

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