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The Indonesian Journal of Dental Research
Published by Universitas Gadjah Mada
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Dentistry
Arjuna Subject : -
Articles 12 Documents
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Search results for , issue "Vol 1, No 1 (2010)" : 12 Documents clear
Augmentation of Demineralized Bone Matrix Post-Tooth Extraction Increases The Density of Gingival Collagen Fiber of Rabbit Mandible Regina TC Tandelilin
The Indonesian Journal of Dental Research Vol 1, No 1 (2010)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (918.323 KB) | DOI: 10.22146/theindjdentres.10174

Abstract

Most cases report that the abnormality of bone defect is engendered by tooth extraction. The powder of demineralized bone matrix (DBM) is required to fill alveolus bone for reconstructing material or preventingtissues defect after tooth extraction. The aim of this study was to determine the density of gingival collagen fiber on wound healing after the augmentation of DBM following the extraction of incisivus tooth. In this study, 36 male rabbits aged 2.5-3 months weighing 900-1,100 grams were randomly divided into two groups: control and treated rabbits. The incisivus teeth of mandibles of treated rabbits were extracted and augmented with the allograft DBM powder. The gingival was sutured with non-absorbable sutures. The same procedures were employed to the control group, except that these rabbits were augmented with DBM powder. Subsequently, the rabbits were sacrificed on days 1, 3, 5, 7, 10, and 14 after surgery, and each observation was represented by three rabbits in the sample. The gingival (ca. 0.5-1cm) was cut and fixed immediately in 10% paraformaldehide. The staining was done using van Geison. In the treated rabbits, the density of gingival collagen fiber significantly increases in all observation days except on first day, indicating that the allograft powder of DBM successfully accelerates the wound healing process.
Systemic IL-1β and TNF-α Productions of E. coli Lipopolysaccharide-Induced Periodontitis Model on Rats Alma Linggar Jonarta; Widya Asmara; Indwiani Astuti; Regina TC Tandelilin
The Indonesian Journal of Dental Research Vol 1, No 1 (2010)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (690.622 KB) | DOI: 10.22146/theindjdentres.9988

Abstract

Periodontal disease, a common inflammatory oral disease involved periodontal tissues, has been linked with the evidence of some systemic disorders. Recently, periodontal disease has been suspected as a trigger of systemic disorders. Penetration of bacterial products, such as lipopolysaccharide (LPS) may reach into deeper periodontal tissues. Therefore there may affect systemic blood and cytokines production. Interleukin-1β (IL-1β) and Tumour Nuclear Factor-α (TNF-α) are known as pro-inflammatory cytokines. The production of systemic IL-1β and TNF-α of E. coli lipopolysaccharide-induced periodontitis model on rats was investigated in this research. Fifteen male Wistar rats, aged 6-8 weeks used for this study were divided into 3 groups. For group 1 and 2, silk ligature 3/0 were inserted in interdental area between upper right molar 1 and 2. First and second group received solution containing 10μg/ml and 1mg/ml E. coli lipopolysaccharide, respectively, mixedwith 2% carboxymethylcellulose (CMC) diluted in 100μl of phosphate buffer saline (PBS). The solution was topically applied on gingival tissues around the gingival sulcus, a single topical application of solution onceper 2 days for 14 days. Untreated subjects were used as negative control. On day 15, the blood was collected from vena orbitalis, and rats were sacrificed. The blood serum of each group was divided into 2 groups andcultured for 4 hours with or without 20μl of 100ng/ml of E. coli LPS. ELISA techniques were used to measure the cytokine productions of the supernatant. The data was analysed using Repeated Measure ANOVA. This study showed that there was a significant increase of IL-1β production on low dose of LPS compared to control and high dose of LPS groups (p<0.05). Whereas TNF-α not significantly showed increasing trend. The increasing trend of pro-inflammatory cytokine productions, such as IL-1β and TNF-α, on LPS-induced periodontitis model in this experiment supports the previous studies about the contribution of periodontal disease in the pathogenesis of systemic diseases.

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