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The Indonesian Journal of Dental Research
Published by Universitas Gadjah Mada
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Dentistry
Arjuna Subject : -
Articles 4 Documents
 1 
Search results for , issue "Vol 1, No 3 (2011)" : 4 Documents clear
Influence of Exposing Root Canal Dentin to Calcium Hydroxide on Its Flexural Strength Diatri Nari Ratih
The Indonesian Journal of Dental Research Vol 1, No 3 (2011)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.514 KB) | DOI: 10.22146/theindjdentres.10063

Abstract

Calcium hydroxide has been used extensively in endodontic treatments, for instance as an intra-canal dressing; however, the exposure of root canal dentin to calcium hydroxide may affect its flexural strength and could have important clinical implications for endodontic treatment. The purpose of this in vitro study was to investigate the influence of calcium hydroxide on the flexural strength of root canal dentin.Seventy-two extracted single-rooted human mandibular premolars were used in this study. Each tooth was instrumented using crown-down technique and was irrigated using sterile saline. The teeth were assigned into three groups of 24 each. The prepared root canal system of each tooth was filled with calcium hydroxide mixed with sterile saline (group 1), a calcium hydroxide commercially available product (UltraCal®) (group 2) or saline solution (group 3, as control). The apices and access opening were sealed using composite resin, and the teeth were immersed in artificial saliva. After 7, 14 and 30 days of immersion, the inner root canal dentin of 8 teeth respectively from each group were sectioned to create dentin bars (1 X 1 mm, with 7 mm in length). Each dentin bar then was subjected to a three-point bending flexural test using MTS (Universal Testing Machine). Data gathered were then analyzed using two-way ANOVA, followed by Tukey’s test with the level of significance of 95%. The results showed that exposure to calcium hydroxide either using calcium hydroxide mixed with sterile saline or UltraCal® for 14 and 30 days can reduce flexural strength of root canal dentin compared to control group (p<0.05). In contrast, after 7 days exposure, there was no significantly different of flexural strength between three groups (p>0.05).   It can be concluded that calcium hydroxide reduced the flexural strength of root canal dentin. The longer the exposure to calcium hydroxide would produce a greater effect on flexural strength of root canal dentin.   
Chemical Effectiveness of Salvadora persica and Commercially Available Whitening Toothpaste on Preventing Tea and Chlorhexidine Stain (in vitro study) Erlina Sih Mahanani; Erry Mochamad Arief; Puteri Ezdiani Binti Mohamed Ismail
The Indonesian Journal of Dental Research Vol 1, No 3 (2011)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (512.451 KB) | DOI: 10.22146/theindjdentres.10064

Abstract

Salvadora persica, a plant that contains a wide range of healthy components, has been used as chewing stick for ages to maintain good oral hygiene and currently has been approved to remove stains. However, its stain-preventing effect is still under investigation. This study aimed to investigate the effectiveness of Salvadora persica and commercially available whitening toothpastes on preventing tea and chlorhexidine stains. Sixty clear acrylic blocks were used and divided into 3 groups, 20 for each group. First group was treated with drinking water, second with commercially available whitening toothpaste and third with whitening toothpaste containing Salvadora persica extract. Baseline measurement by spectrophotometer was taken before starting the procedure. All specimens were immersed in artificial saliva for 2 minutes, rinsed in distilled water and exposed in 0.2% chlorhexidine and tea solution. These cycles were performed 8 times a day for 5 days. Intervention with whitening toothpaste was done for 2 minutes; twice a day. Eventually, all blocks were removed, washed and dried. Stain was assessed by spectrophotometer and visual assessment using Lobene stain index (1968). This study results showed significant differences among groups (Kruskal-Wallis test, p<0.001) and Salvadora persica extract was found to be more effective than commercially availablewhitening toothpaste on preventing stain formation
The Newly Bone Formation with Carbonate Apatite-Chitosan Bone Substitute in the Rat Tibia Anne Handrini Dewi; Andi Triawan
The Indonesian Journal of Dental Research Vol 1, No 3 (2011)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4497.936 KB) | DOI: 10.22146/theindjdentres.10065

Abstract

Large bone defect still represent a major problem in orthopedics. A tissue engineering approach has been proposed where osteogenic cells, bioceramic scaffolds and growth factors can play in a role to the bone repair. Bone consist a mineral phase such as carbonate apatite and an organic phase such as collagen. Synthetic carbonate apatite ceramics are considered as promising alloplastic materials for bone substitute. Chitin is the organic matrix of the hard parts of exoskeleton of insect, crustacean and present in a small amounts in mushrooms. It is an insoluble, similar to cellulose and composed of N-acetylglucosamine unit. Partial deacetylation from chitin result in the formation of chitosan. Chitin’s properties as a flexible and strong material make it favourable as surgical thread. It has novel properties such as biocompatibility, biodegradability, anti bacterial, wound healing activity, tissue regeneration and hemostatic activitities. The composit from carbonate apatite and chitosan may have a great impact on human health care system as bioresorbable bone substitute. The aim of the study was to evaluate the newly bone formation on the bone healing of defect tibia treated with carbonate apatite-chitosan bone substitute. Eighteen Sprague Dawley rats, male, 3 months, weighing 250-300g used in this study. Bilateral defect were created in each tibia rat. The defects were filled with carbonate-apatite chitosan bone substitute. The rats were sacrificed after respectively 1, 2 and 3 weeks. The result of this study showed that carbonate apatite-chitosan significantly increased a number of osteoblast (p<0.05). Carbonate apatite-chitosan group showed that matrix deposition faster than the other groups and have a good interface with the old bone. These data indicate that carbonate apatite-chitosan are potential candidate for bone substitute
Dynamic Changes of Sp6 Transgene Expression in Dental Epithelial Cells during Long-term Culture Trianna W. Utami; Keiko Miyoshi; Hiroko Hagita; Ryna D. Yanuaryska; Taigo Horiguchi; Takafumi Noma
The Indonesian Journal of Dental Research Vol 1, No 3 (2011)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1095.22 KB) | DOI: 10.22146/theindjdentres.10009

Abstract

To investigate the function of specificity protein 6 (SP6) transcription factor by gain-of-function procedure, we established cytomegalovirus (CMV) promoter-driven Sp6 stable transformants, C9 cells, using dental epithelialderived cells. Initially, C9 cells produced a significant amount of SP6 protein. However, SP6 expression was reduced in these cells upon long-term culture. We could detect Sp6 transcripts in C9 cells by RT-PCR throughout the passages, although the CMV promoter is known to be epigenetically silenced. We recently found that SP6 was a short-lived protein that was degraded by a ubiquitin-independent proteasome pathway, although it is yet unclear how Sp6 expression was regulated during culture. Thus, we studied the possibility of epigenetic regulation of Sp6 expression. Comparative analysis of endogenous and exogenous Sp6 mRNA expressions demonstrated the specific down-regulation of exogenous Sp6 mRNA levels during culture passages. A DNA methyltransferase inhibitor, 5-Aza-2'-deoxycytidine (5AC), and a histone deacetylase inhibitor, valproic acid (VPA), enhanced or induced SP6 protein expression up to passage 28 without enhancing the mRNA level. The dramatic up-regulation of exogenous Sp6 mRNA was uniquely observed only at passage 50 by 5AC or VPA treatment. These findings indicate that multiple epigenetic regulatory mechanisms operate to fine-tune Sp6 expression during long-term culture.

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