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Global Medical and Health Communication
Published by Universitas Islam Bandung
ISSN : 23019123     EISSN : 24605441     DOI : https://doi.org/10.29313/gmhc
Core Subject : Health, Science,
Dentistry Health Professions Immunology & microbiology Nursing Public Health
Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
Arjuna Subject : Kedokteran - Epidemilogi
Articles 13 Documents
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Search results for , issue "Vol 5, No 3 (2017)" : 13 Documents clear
Neopterin Serum sebagai Prediktor Dini Luaran Perburukan pada Sepsis Neonatorum Ahmad Hafidz; Tetty Yuniati; Purboyo Solek
Global Medical & Health Communication (GMHC) Vol 5, No 3 (2017)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.292 KB) | DOI: 10.29313/gmhc.v5i3.3101

Abstract

Neopterin telah diketahui sebagai biomarker untuk diagnostik sepsis neonatorum awitan dini. Hingga saat ini belum diketahui peran neopterin sebagai biomarker untuk memprediksi luaran sepsis neonatorum awitan dini maupun awitan lanjut. Tujuan penelitian ini menentukan neopterin serum sebagai biomarker prediktor sepsis neonatorum awitan dini dan lanjut. Penelitian dilakukan pada bulan Mei–Juli 2017 di RSUP Dr. Hasan Sadikin Bandung. Seluruh neonatus yang memenuhi kriteria sepsis neonatorum, yaitu didapatkan skor Tollner ≥10, dilakukan pemeriksaan neopterin serum menggunakan metode ELISA. Subjek kemudian diikuti dan dikelompokkan menjadi luaran perbaikan dan perburukan. Analisis menggunakan receiver operating characteristic (ROC) untuk mendapatkan luas area under curve, menentukan titik potong serta sensitivitas dan spesifisitas. Subjek penelitian terdiri atas 42 neonatus, mayoritas karakteristik neonatus yang mengalami luaran perburukan berjenis kelamin laki-laki (10 subjek), sepsis awitan dini (11 subjek), cara persalinan dengan operasi (11 subjek), dan tempat persalinan di RS (14 subjek). Temuan kadar neopterin pada luaran perburukan lebih tinggi dibanding dengan luaran perbaikan dan disimpulkan terdapat perbedaan yang bermakna (p<0,01). Kadar neopterin rata-rata yang didapatkan pada sepsis luaran perburukan 60,97 ng/mL dengan rentang kadar 40,63–92,04 ng/mL. Luas area di bawah kurva ROC kadar neopterin adalah 0,981 (95% IK=0,882–1,000; p<0,001). Kadar titik potong neopterin >43,13 dengan sensitivitas 94,1% dan spesifisitas 96,0%. Simpulan, kadar titik potong neopterin adalah 43,13 ng/mL serta memiliki sensitivitas 94,1% dan spesifisitas 96,0%. Biomarker ini dapat menjadi salah satu parameter dalam memprediksi dini luaran perburukan sepsis neonatorum awitan dini dan awitan lanjut.NEOPTERIN SERUM AS EARLY PREDICTOR OF POOR OOUTCOME IN NEONATAL SEPSISNeopterin was known as the biomarker for diagnosed early onset neonatal sepsis. Nowadays it has been proven for neopterin as predictors of poor outcome in early and late neonatal sepsis. The objective of this study was to determine serum levels of neopterin as predictors of poor outcome in early and late neonatal sepsis. The study held from May to July 2017 in Dr. Hasan Sadikin General Hospital Bandung. All subjects were neonatal sepsis with Tollner score ≥10 observed for serum levels of neopterin with ELISA method and then followed during hospitalization. The outcome defined as good and poor outcomes. The data were analyzed using receiver operating characteristic (ROC) for getting area under curved, cut-off point and also sensitivity, specificity. Research subjects consisted of 42 neonates, the majority which experienced poor outcomes were male (10 subjects), early onset sepsis (11 subjects), section cesarean procedure (11 subjects) and were born in a hospital (14 subjects). Serum neopterin levels findings significantly correlated with poor outcomes. Mean of poor outcomes in sepsis was 60.97 ng/mL with observed levels 40.63–92.04 ng/mL. Area under the ROC curve of neopterin were 0.981 (95% CI=0.882–1.000; p<0.001). Cut off levels of neopterin >43.13 with sensitivity 94.1% and specificity 96.0%. In conclusion, cut off levels of neopterin >43.13 with sensitivity 94.1% and specificity 96.0%. Neopterin defined as a biomarker for the early predictor of poor outcome in early and late onset neonatal sepsis.
Ekspresi Caspase-3 pada Kanker Payudara Tikus Setelah Pemberian Antikanker Brusein-A Muhartono Muhartono; Subeki Subeki
Global Medical & Health Communication (GMHC) Vol 5, No 3 (2017)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (55.039 KB) | DOI: 10.29313/gmhc.v5i3.2263

Abstract

Brusein-A diduga menyebabkan apoptosis. Salah satu protein yang berperan dalam proses apoptosis adalah caspase-3. Penelitian ini bertujuan mengetahui aktivitas antikanker brusein-A terhadap ekspresi caspase-3 pada kanker payudara. Penelitian menggunakan rancang acak lengkap. Sebanyak 27 ekor tikus betina berumur 12 minggu diberi dimethylbenzanthracene (DMBA) 20 mg/kgBB per oral selama 3 minggu sampai terbentuk kanker payudara. Selanjutnya, dibagi dalam 9 kelompok perlakuan brusein-A, yaitu 0; 2,5; 5; 7,5; 10; 12,5; 15; 17,5; dan 20 mg/L selama 28 hari. Parameter yang diukur adalah ekspresi caspase-3 yang dinilai berdasar atas persentase sitoplasma yang berwarna coklat. Penelitian ini dilakukan di Laboratorium Patologi-Anatomi dan Laboratorium Biokimia, Pusat Penelitian Ilmu Pengetahuan dan Teknologi (Puspiptek) Serpong tahun 2015–2016. Hasil penelitian menunjukkan ekspresi caspase-3 rata-rata pada dosis 0 mg/L sebesar 4%, 2,5 mg/L sebesar 15,3%, 5 mg/L sebesar 21%, 7,5 mg/L sebesar 25%, 10 mg/L sebesar 41%, 12,5 mg/L sebesar 65%, 15 mg/L sebesar 75,3%, 17,5 mg/L sebesar 84%, dan 20 mg/L sebesar 94,7%. Hasil uji one way ANOVA menunjukkan perbedaan ekspresi caspase-3 rata-rata yang signifikan antarkelompok perlakuan (p=0,0001). Uji korelasi Spearman menunjukkan hubungan yang sangat erat dan positif antara dosis brusein-A dan ekspresi caspase-3 (r=0,994). Simpulan, brusein-A meningkatkan ekpresi caspase-3 pada kanker payudara tikus yang diinduksi DMBA.CASPASE-3 EXPRESSION ON BREAST CANCER RATS AFTER BRUSEIN-A ADMINISTRATIONBrusein-A is thought to cause apoptosis. Caspase-3 is a protein that plays a role in the process of apoptosis. This study aims to determine anticancer activity of brusein-A on the expression of caspase-3 in breast cancer. This study uses a completely randomized control design. A total of 27 female rats, 12 week aged, were given 20 mg dimethylbenzanthracene (DMBA)/kgBW peroral for 3 weeks until they had breast cancer. They divided into 9 treatment group of brusein A, that were 0, 2.5, 5, 7.5, 10, 12.5, 15, 17.5, and 20 mg/L for 28 days. Parameter measured were caspase-3 expression, assessed on the percentage of brown cytoplasm. This research was conducted in Pathology-Anatomy Laboratory and Biochemistry Laboratory, Research Center for Science and Technology (Puspiptek) Serpong in 2015–2016. The results showed caspase expression rate of 4%, 15.3%, 21%, 25%, 41%, 65%, 75.3%, 84%, and 94.7% on the dosage of , 2.5, 5, 7.5, 10, 12.5, 15, 17.5, and 20 mg/L respectively. The one way ANOVA test results showed significant difference of caspase-3 expression between treatment group (p=0.0001). Spearman's rank correlation test showed that a very close and positive relationship between brusein-A dose and caspase-3 expression (r=0.994). In conclusion, brusein-A increased caspase-3 expression in DMBA induced breast cancer rats.
Spatial Distribution of Dengue Hemorrhagic Fever (DHF) in Urban Setting of Bandung City Titik Respati; Ardini Raksanagara; Henni Djuhaeni; Asep Sofyan
Global Medical & Health Communication (GMHC) Vol 5, No 3 (2017)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (736.601 KB) | DOI: 10.29313/gmhc.v5i3.2535

Abstract

The proximity of urban area provides fertile ground for the exchange of bacteria, virus and other health problem. One of the diseases which have a close relationship with the environment and people interaction is dengue. At present, it still is one of the major health problems for Indonesia. One method to understand the disease is by using spatial analysis that the prevention program can be focusing on the area most affected. This study aims to analyze the spatial distribution of dengue cases in Bandung city. The method used was the mapping of dengue cases using geographic information system (GIS) with ArcView software. Data were collected from August 2015 to March 2016 in Bandung city. Results showed that dengue cases increased with fluctuated hyperendemic years especially in the year 2009, 2012, and 2013. Spreading pattern of the disease was from north of Bandung to east. The conclusion of this study dengue cases in Bandung city showed an increased trend with fluctuated hyperendemic year especially in the year 2009, 2012, and 2013. Pockets of highest reported cases were found in north to middle and east for the whole year. The spread of this disease, especially in east Bandung, showed wider affected areas in the observed year. Land usage for residential purposes without good development plan might be on factors that increase the disease transmission. DISTRIBUSI SPASIAL KASUS DEMAM BERDARAH DENGUE DI DAERAH URBAN KOTA BANDUNGKedekatan dalam wilayah urban memberikan kemudahan dalam pertukaran bakteri, virus, dan masalah kesehatan lainnya. Salah satu penyakit yang erat hubungannya dengan kedekatan pemukiman, lingkungan, dan interaksi manusia adalah demam berdarah dengue (DBD). Sampai saat ini DBD masih menjadi masalah kesehatan di Indonesia. Pencegahan suatu penyakit akan lebih mudah dilakukan apabila pemahaman mengenai penyakit tersebut sudah dapat dilakukan dengan baik. Dengan pemetaan (distribusi spasial), kasus DBD akan lebih mudah dimonitor sehingga program pencegahan dapat difokuskan pada wilayah dengan angka kejadian yang tinggi. Penelitian ini bertujuan melihat distribusi spasial kasus DBD mempergunakan geografic information system (GIS) di Kota Bandung. Metode penelitian ini adalah pemetaan kasus di wilayah tertentu dengan GIS menggunakan ArcView software menggunakan data kasus DBD dan data spasial dilaksanakan pada tahun 2015 di Kota Bandung. Hasil penelitian kasus DBD di Kota Bandung menunjukkan peningkatan dengan pola tahun hiperendemik berfluktuasi terutama pada tahun 2009, 2012, dan 2013. Pola pergerakan kasus tampak berawal dari arah utara menuju timur. Kantong wilayah dengan kasus DBD yang tinggi terkumpul di daerah utara menuju timur Kota Bandung sepanjang tahun. Simpulan penelitian ini, penyebaran kasus di wilayah Bandung menunjukkan daerah sebaran yang semakin besar dari tahun ke tahun. Pemanfaatan lahan sebagai pemukiman memiliki keterkaitan terhadap kejadian DBD.

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