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INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 6 Documents
 1 
Search results for , issue "Vol 8, No 2 (2019)" : 6 Documents clear
Anatomical and Histological Study of Shark (Carcharhinus sorrah) Kidney Hikmah Supriyati; Rakhmiyati Rakhmiyati; Muhammad Ja’far Luthfi
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.37-40

Abstract

Sharks are sea water fishes belong to the class Chondrichthyes, Subclass Elasmobranchii. Sharks are cartilaginous fish that have a different osmoregulation process than any other sea water fish. Cartilaginous fish is the only vertebrate that can maintain urea. This study aims to determine the anatomical and histological structure of the kidney in the anterior, medial and posterior parts of kidney. The study was conducted by observing anatomy of the kidney. Histological preparations were made using the paraffin method. Qualitative descriptive data analysis was done. Research results show that shark kidneys consist of three parts, namely the head kidney, the body kidney, and the tail kidney. Kidney sharks are brownish red with a size of 18 cm long. Histological observations of shark kidney in the head kidney reveals many glomerulus, body kidney reveals many distal and tubule proximal contractile tubules whereas tail kidney reveals stroma that is rarely found in vertebrate kidney.
Digital Anthropometer Development for Improving the Measurement Quality of Human Body Dimensions Trio Yonathan Teja Kusuma; Arya Wirabhuana; Faurosi Syafa’atul Yusuf
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.27-32

Abstract

Digital information technology has become the nerve of information for industry-based companies. However, there are still data or information that retrieved manually, one of them is measurement of the human body dimension. The problem is seemed solved by invention of digital anthropometer application. Yet, the application requires a further improvement especially in its accuracy and user interface. The improvement of accuracy quality of its measurement uses the capability process analysis method. As a result, the current Cp and Cpk is 0.26 and -0.209 while in the developed application is 2.56 and 1.218. Thus, the developed application is stated that quality of measurement increases to meet the criteria of good process capability. The user interface is improved based on the user voices. Data storage databases and percentile calculation in the application was added as one on the significant user-interface improvement.
The Effects of Wet Cupping Therapy in Blood Pressure, Glucose, Uric Acid and Total Cholesterol Levels Sutriyono Sutriyono; Muhammad Rodham Robbina; Meksianis Zadrak Ndii
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.33-36

Abstract

Wet cupping therapy is a simple, cheap, and effective alternative medical treatment. In China wet cupping therapy become a formal treatment in the hospital. 14 centuries ago Prophet Muhammad implemented wet cupping therapy or hejamah as a curing treatment and become sunnah for muslim. Today in a modern world, many studies proved the advantages of wet cupping therapy, which is a sunnah since 14 centuries ago. The aims of this study were to measure the effects of wet cupping therapy treatment on blood pressure, blood glucose, uric acid, and total cholesterol level. 21 participants were treated with hejamah/wet cupping, blood pressure and blood samples were collected from all the participants one week before and one week after hejamah. Blood pressure, either systolic or diastolic was significantly decreased following therapy (p|<|0.05), blood glucose had a slight decreased but not significant (p|>|0.05). uric acid and total cholesterol level was also significantly decreased following therapy (p|<|0.05). With only just one time treatment, hejamah had a significant effects on blood pressure, uric acid and total cholesterol level, that is proved the advantages of hejamah.
Hepatotoxic Assessment of Tramadol-Diclofenac Use: A Study in a Rat Model Elias Adikwu; Ebinyo Clemente Nelson
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.41-45

Abstract

The concurrent use of tramadol and diclofenac may increase hepatotoxic risk due to their individual hepatotoxic effects. This study assessed the hepatotoxic effect of tramadol-diclofenac administration in albino rats. Twenty-four adult male albino rats (200-220g) randomized into four groups were orally administered with tramadol (12mg/kg/day), diclofenac (6mg/kg/day) and tramadol-diclofenac for 14 days respectively. The rats were anesthetized, blood samples were collected and evaluated for serum liver function and lipid parameters. Liver samples were weighed and evaluated for biochemical parameters and histology. The effects of tramadol-diclofenac on the body and liver weights did not differ significantly (p>0.05) when compared to control. Also, effects were not significant (p>0.05) on blood glucose, and serum cholesterol, triglyceride, low and high density lipoprotein cholesterol levels when compared to control. Liver and serum levels of aminotransferases, alkaline phosphatase, lactate dehydrogenase, gamma–glutamyl transferase, conjugated bilirubin and total bilirubin increased significantly in rats treated with tramadol (p<0.05), diclofenac (p<0.01) and tramadol-diclofenac (p<0.001) when compared to control. Furthermore, significant decreases in liver catalase, glutathione, superoxide dismutase, glutathione peroxidase levels with significant increases in malondialdehyde levels occurred in rats treated with tramadol (p<0.05), diclofenac (p<0.01) and tramadol-diclofenac (p<0.001) when compared to control. Hepatocyte necrosis was observed in rats treated with tramadol-diclofenac. Tramadol-diclofenac may increase hepatotoxic risk at doses used for this study.
Liver Profile of Atazanavir/Ritonavir in Pregnant Albino Rats Elias Adikwu; James Kemelayefa; Winifred Ocheiga
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.47-52

Abstract

Medication use during pregnancy is challenging due to the occurrence of maternal or fetal toxicities. Atazanavir/ritonavir (ATV/r) has hepatotoxic potential hence; use in pregnant patients living with human immunodeficiency virus may cause maternal hepatotoxicity. This study assessed the liver profile of ATV/r in pregnant albino rats. Thirty pregnant albino rats randomized into groups were orally treated daily with ATV/r (4.28/1.43 mg/kg-34.3/11.4 mg/kg) for 16 days. After treatment, the rats were weighed and sacrificed. Blood samples were collected and examined for serum biochemical parameters. Liver samples were weighed and assessed for biochemical and histological changes. Body and liver weights were normal (p>0.05) in ATV/r-treated pregnant rats when compared to control. Serum total cholesterol, triglyceride, low density lipoprotein cholesterol and blood glucose levels were significantly (p<0.01) elevated whereas high density lipoprotein cholesterol level was significantly (p<0.01) decreased in rats treated with ATV/r (34.3/11.4 mg/kg) when compared to control. Liver and serum aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, total bilirubin, and conjugated bilirubin levels were significantly increased in a dose-dependent fashion in rats treated with ATV/r; 8.57/2.86 mg/kg (p<0.05), 17.1/5.72 mg/kg (p<0.01) and 34.3/11.4 mg/kg (p<0.001) when compared to control. Liver superoxide dismutase, catalase, glutathione and glutathione peroxidase levels were significantly decreased whereas malondialdehyde levels were significantly increased in a dose-dependent fashion in rats treated with ATV/r; 8.57/2.86 mg/kg (p<0.05), 17.1/5.72 mg/kg (p<0.01) and 34.3/11.4 mg/kg (p<0.001) when compared to control. Necrotic hepatocytes were observed at higher doses of ATV/r. ATV/r may not be hepatotoxic in pregnant women living with HIV at the clinical dose.
Cover, Editorial Board, Guidance for Authors, & Table of Contents Muhammad Ja&#039;far Luthfi
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.%p

Abstract

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