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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
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Articles 4 Documents
 1 
Search results for , issue " Vol 1, No 2 (2001)" : 4 Documents clear
Uji Toksisitas Kurkumin pada Kultur Sel Luteal Noor, Zulkhah
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 1, No 2 (2001)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/1907

Abstract

Cur cumin, an active substance of turmerics (Curcuma domestica Val.; Cur-cuma xanthorhiza Robx.), is found to be an anti-fertility substance. The re¬search was aimed to examine the toxicity of curcumin to ovarian cell, espe¬cially luteal cell and to investigate the threshold of curcumin toxicity to luteal¬cell culture.The sample used were luteal cell cultures of 3-day-old corpus luteum of immature Sprague-Dawley rats which received ovulation induction of 8 iu PMSG. Luteal cell cultures were divided into 7 groups (n-10), each of which was given curcumin (mg/ml) 0 (vehicle); 0.075; 0.15; 0.3; 0.6; 1.2; 2.4, and incubated for 24 hours. Toxicity effect of curcumin was counted by hemocy- tometer with trypan blue. The difference of alive-cell number of each group was tested statistically with student t-test and Cythopatic Effect (CPE.J is counted with Reed & Muench formulation.Student t-test of mean data of alive cell showed significant difference (p<0.05) between the control group and groups which were given curcumin the same or greater than 0.15 mg/ml. Cythopatic Effect (CPE30) of curcumin to cell luteal culture is 0.55 mg/ml.Kurkumin zat aktif yang terdapat dalam rimpang kunyit (curcuma domestica Val), temulawak (Curcuma xanthorriza Robx) dan beberapa marga curcuma, ditemukan memiliki efek anti fertilitas. Penelitian ini dilakukan untuk uji toksisitas kurkumin pada sel ovarium untuk mengetahui ambang batas kurkumin yang menyebabkan kematian sel (toksis).Sampel penelitian adalah kultur sel luteal dari korpus luteum umur tiga hari dari tikus Sprague Dawley prepubertal yang mendapat induksi ovulasi dengan 8 iu PMSG. Kultur sel luteal dikelompokkam menjadi 7 kelompok (n=10), masing-masing kelompok mendapat kurkumin kadar bertingkat(mg/ml) 0; 0,075,0,15; 0,3; 0,6; 1,2; dan 2,4; kemudian diinkubasi selama 24 jam . Efek toksis kurkumin (kematian sel) dihitung menggunakan hemositometer dengan zat warna tripan blue. Perbedaan jumlah sel hidup tiap kelompok di uji dengan student t-test. Sedangkan Cythopatic Effect (CPE50) dihitung dengan rumus Reed & Muench.Student t-test rerata data sel luteal hidup menunjukkan perbedaan bermakna p<0,05) antara kelompok kontrol dengan kelompok yang mendapat kurkumin mulai konsentrasi 0,15 mg/ml. Perhitungan Cythopatic Effect (CPE50) kadar kurkumin sintesis mumi dalam metanol yang menyebabkan kematian sel luteal umur tiga hari sebanyak 50% adalah 0,55 mg/ml.
Motilitas dan Viabilitas Spermatozoa Mencit ( Mus musculus) Setelah Pemberian Solasodin yang Diisolasi dari Terong Kuning (Solatium khasianum) Wahyuni, Alfaina
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 1, No 2 (2001)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

The eggplant is consumed and used in traditional medication, for example to reduce male desire. One of the solanum’s alkaloid which may affect on reproduction is solasodine , but it is still unclear. This study was conducted to investigate the effects of solasodine on sperm motility and viability in adult mice.Twenty five healthy mice, 3 months old, and 37- 45 gram of body weight were used. They were divided into five groups. Each group consisted of five mice. Group I, control without any treatment (Kl), group II, treatment with solvent of solasodine, polyvinylpirollidon 1% in aquadest (K2), group III, treatment with solasodine 87,61 mg/kgBw/day (PI), group IV, treatment with solasodine 175,62 mg/kgBW/day (P2) and group V, treatment with solasodine 263,43 mg/kgBW/day (P3). Treatments were given in 36 days. In the 37th day mice were killed for evaluation of sperm motility and viability. The result of this study shows that sperm motility and viability in all treatment groups were significantly reduced (Analysis of Variance cintinued with least significant difference, p < 0,05).Terong banyak dikonsumsi masyarakat dan digunakan sebagai bahan obat osional misalnya untuk menurunkan nafsu seks pria. Salah satu alkaloid solanum ;;~‘Z kemungkinan berpengaruh terhadap fungsi reproduksi adalah solasodin, tetapi . mi masih belum jelas dan perlu penelitian lebih lanjut, Penelitian ini dilakukan eik mengetahui pengaruh pemberian solasodin terhadap kualitas spermatozoa lisusnya motilitas dan viabilitas spermatozoa mencit dewasa.Digunakan 25 ekor mencit jantan umur 3 bulan, sehat, berat 37-45 gram.Mencit i fiompokkan menjadi 5 kelompok, tiap kelompok terdiri dari 5 ekor mencit. i rmpok I, kontrol tanpa perlakuan apapun (Kl), kelompok II, diberi larutan vinylpyrollidon 1% dalam aquadest(K2), kelompok III, diberi perlakuan solasodin ;: s 87,81 mg/kgBB/hr (Pl), kelompok IV, diberi solasodin dosis 175,63 mg/kgBB/ in kelompok V diberi solasodin 263,43 mg/kgBB/hr. Perlakuan diberikan selama : izii kemudian pada hari ke-37 semua mencit dimatikan dan diambil cauda :ijdmisnya untuk pemeriksaan motilitas dan viabilitas spermatozoa. Hasil penelitian lezunjukkan bahwa pada semua kelompok perlakuan terjadi penurunan motilitas BE iabilitas spermatozoa secara bermakna (Analisis varian dilanjutkan dengan uji 12 nyata terkecil, p < 0,05).
Arteria Renalis Accessoria Estri, Siti Aminah Tri Susilo
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 1, No 2 (2001)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

The vascularisation of the kidneys varies in number and location. The kidney that has two or more renal arteries found in 25-30% of population. The variation of renal arteries arises as result of the persistence of embryonic vessel that normally degeneratic when definitive renal arteries are formed.Vascularisation variation of the kidney in the forms of renalis artery and accessory renal artery were found in one of five cadavers dissected in the Laboratory of Anatomy, Faculty of Medicine, Muhammadiyah University of Yogyakarta.The left kidney has one principal artery and one accessory artery that branched from abdominal aorta. The accessory renal artery was located in the inferior of the principal artery and passed the inferior polus of the left kidney. In this case no obstruction of the ureter nor hydronephrosis was found as the main clinical feature usually observed in the cases.Vaskularisasi pada ren bervariasi pada jumlah dan posisi . Pada 25% - 30% populasi ditemukan adanya ren yang mempunyai 2 atau lebih arteria renalis. Variasi ini berasal dari tetap adanya vasa darah embryonal yang seharusnya mengalami degenerasi ketika vasa renalis (definitive) terbentuk.Variasi vaskularisasi pada ren berupa arteria renalis dan satu arteria renalis accessoria telah ditemukan pada saat diseksi kadafer ke-5 kali di Laboratorium Anatomi Universitas Muhammadiyah Yogyakarta.Ren sinistra tampak mempunyai a. renalis sinistra (principalis) dan satu a. renalis accessoria, yang dipercabangkan langsung dari aortae abdominalis. Arteria renalis accessoria terletak di sebelah inferior dari a. renalis sinistra dan pergi ke polus inferior ren sinistrae. Pada kasus ini tidak ditemukan adanya obstruksi ureter maupun hidronefrosis.
Gambaran Pendistribusian Kartu Sehat pada Program JPSBK di Wilayah Propinsi Daerah Istimewa Yogyakarta Achmawati, Faridha; Mukti, Ali Ghufron; Prabandari, Yayi Suryo
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 1, No 2 (2001)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

The social and political crisis happening since July 1997 has affected the economic condition among Indonesians, as well as their health condition. In terms of health field, the government has held JPSBK or Health- Based Social Safety Net.The objective of this reseach is to learn the distribution of health cards provided for the community in Yogyakarta Special Province.This was an evaluative study using post-test only with secondary data from PIMU (Province Independent Monitoring Unit) survey in Yogyakarta in 2001. This study was conducted in 10 community health centers in Yogyakarta Province, and from those 10 community health centers, 220 re¬spondents were obtained.From the poverty criteria from BKKBN or National Family Planning Field Coordinator and village team, it was found that the criteria for family members of the poor that 99.1% of them could eat the basic food twice a day. All 95 % family members had different clothes to wear at home, in the office or school, and travelling. Fifty point nine percent family members joined family planning using health facility.Ninety-four point one percent of the family members went to health facil¬ity. Sixty one point four percent of the floor of the poor family ’s houses was not clay. Fifty two point three percent of the walls of their houses were made of cement and 98.2 %. of the ceilings were made of tiles. Forty fife percents of the respondents had cattles at home.This reseach showed that the distribution of health cards in Yogyakarta has not been appropriate, as there are many holders who do not full f ill the criteria as cardholders (BKKBN poverty criteria & Village Team).Krisis politik dan krisis sosial yang terjadi sejak bulan Juli 1997 telah menimbulkan dampak yang besar sekali pada kondisi ekonomi masyarakat Indo¬nesia termasuk pada kondisi kesehatannya. Khusus untuk bidang kesehatan, pemerintah melaksanakan program Jaring Pengaman Sosial Bidang Kesehatan JPSBK) .Tujuan dari penelitian ini adalah untuk mengetahui bagaimana gambaran pendistribusian Kartu Sehat yang diberikan pada masyarakat di wilayah Propinsi Daerah Istimewa Yogyakarta.Penelitian ini merupakan penelitian jenis evaluatif dengan rancangan post test only yang menggunakan data sekunder dari hasil survey PIMU (Province inde¬pendent Monitoring Unit) Propinsi Daerah Istimewa Yogyakarta tahun 2001. Penelitian dilakukan pada 10 puskesmas di Propinsi Daerah istimewa Yogyakarta, dari 10 puskesmas tersebut didapatkan responden berjumlah 220.Kriteria miskin dari BKKBN dan tim desa didapatkan kriteria seluruh anggota keluarga bisa makan makanan pokok sehari 2 kali atau lebih berjumlah 99.1 %, seluruh anggota keluarga memiliki pakaian yang berbeda untuk digunakan ii rumah, bekerja/sekolah, dan berpergian berjumlah 95%, bila ada Pasangan Usia Subur yang ingin melaksanakan KB pergi ke sarana / petugas kesehatan berjumlah 50,9%, seluruh anggota keluarga bila sakit dibawa ke sarana / fasilitas kesehatan berjumlah 94,1 %, bagian terluas lantai bukan dari tanah berjumlah 61,4%, dinding terluas rumah dari tembok berjumlah 52,3%, atap rumah terluas dari genting berjumlah 98,2%, ditambah dengan kepemilikan ternak dari 220 responden yang menjawab memiliki ternak ada 45%.Dari hasil penelitian diketahui bahwa pendistribusian Kartu Sehat di wilayah Propinsi Daerah Istimewa Yogyakarta belum sesuai dengan yang diharapkan karena masih banyak penerima Kartu Sehat yang tidak memenuhi kriteria sebagai penerima Kartu Sehat (kriteria miskin dari BKKBN dan dari tim desa).

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