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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 3 Documents
 1 
Search results for , issue " Vol 8, No 1 (2008)" : 3 Documents clear
Modifikasi Protein Akibat Pembebanan Glukosa dengan Model Reaksi Glikosilasi Nonenzimatik in vitro Suhartono, Eko; Setiawan, Bambang; Mashuri, -; Juniarti, Maya; Kamilah, Insanul; Haudhiya, -
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2008)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Glycocylation reaction causes protein modification. Glycocylation is a reaction between aldehyde group from reducing sugar with amine group of protein. The aim of this study was to measure Advanced Glycation End Products (AGEs) formation, dicarbonyl compound and tyrosine degradation in glycocylation reaction in vitro. A quasi experimental study was done to four treated groups, i.e. P1= 5 ml Bovine Serum Albumin (BSA), 10 ml phosphate buffer dan 10 ml aquadest; P2= 5 ml BSA, 10 ml phosphate buffer and 10 ml glucose 125 mM; P3= 5 ml BSA, 10 ml phosphate buffer and 10 ml glucose 250 mM; P4= 5 ml BSA, 10 ml phosphate buffer and 10 ml glucose 500 mM. AGEs compound was measured for 21 days using spectrophotometer at X = 390 nm. Dicarbonyl compound was measured by DNPH odification methods at X = 470 nm. Tyrosine degradation was measured usingMillon-Nasse reaction. Anova and Tuckey HSD test concluded there are significant difference between each groups (P<0,05). Based on correlation regresion test conclude that the increase of dicarbonyl compounds, AGEs and tyrosine degradation had positive correlation with increase of glucose concentration. Glucose overloading could induce protein modification in vitro.Salah satu penyebab modifikasi protein adalah reaksi glikosilasi. Reaksi glikosilasi adalah reaksi antara gugus aldehid gula pereduksi dengan gugus amina protein. Penelitian ini bertujuan mengukur Advanced Glycation End Products (AGEs), senyawa dikarbonil maupun degradasi tirosin pada reaksi glikosilasi in vitro. Penelitian ini merupakan penelitian eksperimental semu denganpre andpost control group design terhadap empat kelompok perlakuan, yaitu P1= 5 ml Bovine Serum Albumin (BSA), 10 ml buffer fosfat dan 10 ml aquadest; P2= 5 ml BSA, 10 ml buffer fosfat dan 10 ml glukosa 125 mM; P3= 5 ml BSA, 10 ml buffer fosfat dan 10 ml glukosa 250 mM; P4= 5 ml BSA, 10 ml buffer fosfat dan 10 ml glukosa 500 mM. Absorbansi senyawa AGEs diukur selama 21 hari pada X = 340 nm sedangkan absorbansi senyawa dikarbonil diukur dengan X = 390 nm dan absorbansi degradasi tirosin dengan k=470 nm. Pengukuran absorbansi senyawa dikarbonil menggunakan metoda DNPH yang dimodifikasi, sedangkan pengukuran degradasi tirosin menggunakan reaksi Millon-Nasse. Berdasarkan hasil uji Anova dan Beda Nyata Jujur, disimpulkan bahwa terdapat perbedaan yang signifikan (P<0,05) tiap kelompok perlakuan. Berdasarkan uji korelasi regresi dapat disimpulkan bahwa pembentukan senyawa dikarbonil, AGEs dan degradasi tirosin berkorelasi positif dengan peningkatan konsentrasi glukosa. Pembebanan glukosa yang berlebih dapat memicu modifikasi protein in vitro.
Gambaran Diet Anak Usia Sekolah di Desa Sidoharjo, Kulon Progo, terhadap Standar Normal Pertumbuhannya Astuti, Yoni; Meida, Nur Shani
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2008)
Publisher : Universitas Muhammadiyah Yogyakarta

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Child growth and development are influenced by several factors including hereditary and environment factors. The environment factors that potentially influence child growth and differentiation are diet and health. Diet intake in children is expected to meet the Recommended Dietary Allowance (RDA) to enable good growth and development. The aim of this research is to identify diet description of school children in Sidoharjo District, Kulon Progo towards their normal standard of growth. The research subjects were 63 school children consisting of 33 girls and 30 boys aged 7-12 years old. This research was carried out by filling out a questionnaire consisting of respondent identity and diet survey form to record diet intake for 7 consecutive days. Subjects then underwent general physical examination i.e. bloodpressure, pulse, respiration rate, body height and weight. The results of this research showed that most children (> 80 %) had growth and development under 50% of percentile. The calorie intake was 50 % of RDA. The intake of carbohydrate, protein and lipid of the group of boys was 85,32%; 5,2%; 9,48% respectively. The intake of carbohydrate, protein and lipid of the group of girls was 83,2%; 6,5%; and 10,3% respectively. Therefore, the school children diet was below the RDA level.Pertumbuhan dan perkembangan anak dipengaruhi oleh banyak faktor diantaranya faktor herediter dan lingkungan. Faktor lingkungan yang potensial mempengaruhi pertumbuhan dan perkembangan anak antara lain diet dan kesehatannya. Asupan makanan pada anak di harapkan sesuai dengan RDA(Recommended Dietary Allowance) nya, agar pertumbuhan dan perkembangan anak dapat baik. Penelitian ini bertujuan untuk mengetahui gambaran diet anak usia sekolah (SD) di dusun Sidoharjo Kulon Progo terhadap standard normal pertumbuhannya. Subyek penelitian ini sebanyak 63 anak terbagi atas 33 anak perempuan dan 30 anak laki - laki, dengan kisaran umur 7-12 tahun. Penelitian dilakukan dengan cara mengisi kuesioner yang berisi identitas dan blangko survey diet untuk mencatat semua makanan yang dimakan berturut- turut selama 7 hari. Selanjutnya subjek diperiksa kesehatannya secara umum dengan pemeriksaan tekanan darah, nadi, respirasi, tinggi dan berat badan. Hasil penelitian menunjukkan bahwa pertumbuhan dan perkembangan anak baik perempuan dan laki - laki sebagian besar (> 80 %) di bawah persentil 50%.Asupan kalori hanya terpenuhi 50%nya. Kelompok perempuan asupan karbohidrat, protein dan lemak berturut - turut terpenuhi sebesar 85,32% , protein 5,2% dan lemak 9,48%, sedangkan pada kelompok laki - laki berturut turut 83,2%, 6,5%, dan 10,3%. Kesimpulan penelitian ini adalah diet anak - anak usia sekolah di dusun Sidoharjo, Kulon Progo berada di bawah Standar Normal Pertumbuhannya (RDA).
Permasalahan-permasalahan yang Menyertai Erupsi Gigi Kurniasih, Indri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2008)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Tooth eruption process is an normal physiological process. It may become abnormal there disturbances intervered within the process. Several disturbances such as trauma, hereditary factors, and pathological disorders can cause some problems which may leads to dental disorders if it were remain untreated. These matters have to become a serious concern of the dentists. There are several problems which are frequently associated with tooth eruption process such as ankylosis, eruption cyst, eruption hematoma and ectopic eruption. Each of these problems has their own specific clinical characteristic .Moreover, some of the problems needs special treatments to assure that dental anomaly resulted will not develop further and dental eruption is not disturbed. The aim of the writing is to elaborate the etiology, sign and clinical symptoms, and also treatment of problems during tooth eruption.Proses erupsi gigi merupakan suatu proses fisiologis yang normal. Bisa menjadi tidak normal ketika terjadi gangguan pada proses tersebut. Beberapa gangguan berupa trauma, faktor herediter, kondisi patologis terkadang menimbulkan permasalahan yang jika dibiarkan akan berlanjut menimbulkan kelainan pada gigi. Hal ini perlu menjadi perhatian serius oleh dokter gigi. Ada beberapa permasalahan yang sering menyertai proses erupsi gigi diantaranya ankylosis, eruption cyst, eruption hematoma dan ectopic eruption. Permasalahan-permasalahan tersebut mempunyai karakteristik yang khas. Beberapa diantaranya bahkan memerlukan penanganan khusus agar kelainan gigi tidak berlanjut dan proses erupsi gigi tidak terganggu. Penulisan ini bertujuan untuk menguraikan tentang etiologi, tanda dan gejala klinis serta perawatan dari permasalahan-permasalahan yang timbul selama proses erupsi gigi.

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