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Dental Journal (Majalah Kedokteran Gigi)
Published by Universitas Airlangga
ISSN : 19783728     EISSN : 24429740     DOI : -
Core Subject : Health,
Dentistry
The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries.
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Articles 11 Documents
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Search results for , issue "Vol. 44 No. 2 (2011): June 2011" : 11 Documents clear
The activity of Stichopus hermanii extract on triglyceride serum level in periodontitis Rima Parwati Sari; Syamsulina Revianti
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 2 (2011): June 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.562 KB) | DOI: 10.20473/j.djmkg.v44.i2.p106-110

Abstract

Background: The level of triglyceride can be used as a parameter of  hypercholesterolemia. Periodontitis can make the condition of hypercholesterolemia worse. Stichopus hermanii extract is a source of saturated fatty acid containing omega-3 which can decrease triglyceride blood level. Purpose: The aim of this research was to investigate the effect of Stichopus hermanii extract in triglyceride blood level of wistar rats which got periodontitis. Methods: The samples of this research were 30 rats divided into 5 groups, namely group K(–) as negative control group (without treatment), group K(+) as positive control group (induced with periodontopathogen mix), group P1 as treatment group1 (induced with periodontopathogen and Stichopus hermanii extract mix, 0.09 ml/kgW), Group P2 (induced with periodontopathogen and Stichopus hermanii extract mix, 0,18 ml/kgW), and group P3 (induced with periodontopathogen and Stichopus hermanii extract mix, 0,36 ml/kgW). Then, all of those rats were sacrificed and all serum was measured for their level of triglyceride. Results: All data was analyzed with ANOVA test showing a significant result. LSD test showed a significant different between group K(–) and group K(+), and between group K(+) and group P2 and P3. Conclusion: Stichopus hermanii extract can decrease the triglyceride blood level in wistar rats with periodontitis.Latar belakang: Kadar trigliserida dalam darah dapat digunakan sebagai parameter hiperkolesterolemia. Periodontitis dapat memperburuk kondisi hiperkolesterolemia. Stichopus hermanii ekstrak mengandung asam lemak jenuh terutama omega-3 yang dapat berfungsi menurunkan kadar trigliserida dalam darah. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui pengaruh ekstrak Stichopus hermanii terhadap kadar trigliserida dalam darah tikus wistar yang mengalami periodontitis. Metode: Sampel penelitian ini adalah 30 ekor tikus wistar yang dibagi dalam 5 kelompok. Kelompok K(–) sebagai kelompok kontrol negatif (tanpa perlakuan), kelompok K(+) sebagai kelompok kontrol positif (tikus diinduksi periodontopatogen campuran), kelompok P1 sebagai kelompok perlakuan 1 (tikus diinduksi periodontopatogen campuran dan Stichopus hermanii ekstrak 0,09 ml/kgW), kelompok P2 (tikus diinduksi periodontopatogen campuran dan Stichopus hermanii ekstrak 0,18 ml/kgW) dan P3 (tikus diinduksi periodontopatogen campuran dan Stichopus hermanii ekstrak 0,36 ml/kgW). Kemudian semua tikus dikorbankan dan diukur kadar trigliserida serumnya. Hasil: Semua data dianalisis dengan uji ANOVA dan menunjukkan hasil yang signifikan, dan uji LSD menunjukkan terdapat perberbedaan yang bermakna antara kelompok K(–) dengan K(+) dan kelompok K(+) dengan P2 dan P3. Kesimpulan: Ekstrak Stichopus hermanii dapat menurunkan kadar trigliserida darah pada tikus wistar yang mengalami periodontitis.

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