cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Saka Winias
Contact Email
saka.winias@gmail.com
Phone
-
Journal Mail Official
dental_journal@yahoo.com
Editorial Address
-
Location
Kota surabaya,
Jawa timur
INDONESIA
Dental Journal (Majalah Kedokteran Gigi)
Published by Universitas Airlangga
ISSN : 19783728     EISSN : 24429740     DOI : -
Core Subject : Health,
Dentistry
The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries.
Arjuna Subject : -
Articles 11 Documents
 1   2 
Search results for , issue "Vol. 46 No. 3 (2013): September 2013" : 11 Documents clear
Korelasi antara jumlah mikronukleus dan ekspresi 8-oxo-dG akibat paparan radiografi panoramic (The correlation of micronucleus formation and 8-oxo-dG expression due to the panoramic radiography exposure) Rurie Ratna Shantiningsih; Suwaldi Suwaldi; Indwiani Astuti; Munakhir Mudjosemedi
Dental Journal (Majalah Kedokteran Gigi) Vol. 46 No. 3 (2013): September 2013
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (477.241 KB) | DOI: 10.20473/j.djmkg.v46.i3.p119-123

Abstract

Background: The expression of 8-oxo-dG is defined as one form of damaged DNA occuring as the result of oxidation reaction due to X ray exposure. Panoramic radiography exposure has been widely known to be able to increase micronucleus which are signing the early stage and as biomarker in carsinogenesis mechanism. Purpose: The purpose of this research was to determine the correlation between micronucleus number and 8-oxo-dG expression as a result of panoramic radiography exposure. Methods: Twelve New Zealand male rabbits aging 6 months were divided into 4 groups. Group I were rabbits that represented 0 day, group II represented 3th day, group III represented 6th day, and group IV represented 9th day after the panoramic radiography exposure. Respectively samples were swabbed at mandibular anterior gingival mucosa before and after the panoramic radiography exposure. The swabbed samples were coloured by using Feulgen-Rossenbeck modified staining for calculating the amount of micronucleus formation. Expression of 8-oxodG was detected using immunohistochemical of rabbit’s gingival mucosa epithelium. Statistical analysis were carried out on pearson correlation. Results: There was a highest increasing of micronucleus on the 9th day after panoramic radiography exposure. Meanwhile, there was significant correlation (p=0,049) of the increasing amount of micronucleus and 8-oxo-dG expression in negatively correlation (r = -0,578). The increasing of micronucleus formation on the 9th day after panoramic radiography exposure was accordance with some previous studies. The expression score of 8-oxo-dG decreases as the day goes by. Conclusion: There was a correlation between the number of micronucleus and expression score of 8-oxo-dG.Latar belakang: Ekspresi 8-oxo-dG adalah suatu bentuk kerusakan DNA yang terjadi akibat reaksi oksidatif dari paparan sinar X. Paparan radiografi panoramik telah diketahui menyebabkan peningkatan jumlah mikronukleus yang merupakan biomarker tahap dini mekanisme karsinogenesis. Tujuan: Tujuan penelitian ini adalah untuk meneliti korelasi antara jumlah mikronukleus dan ekspresi 8-oxo-dG akibat paparan radiografi panoramik. Metode: Sebanyak 12 ekor kelinci New Zealand jantan usia 6 bulan dibagi menjadi 4 kelompok. Kelompok I merupakan kelinci untuk mewakili hari ke-0, kelompok II untuk mewakili hari ke-3, kelompok III untuk mewakili hari ke-6, dan kelompok IV untuk mewakili hari ke-9 setelah paparan radiografi panoramik. Terhadap seluruh kelinci dilakukan usapan pada mukosa gingiva anterior rahang bawah sebelum dan sesudah dilakukan paparan radiografi. Selanjutnya terhadap sampel usapan itu dilakukan pewarnaan menggunakan teknik pewarnaan modifikasi Feulgen-Rossenbeck untuk menghitung jumlah mikronukleus. Ekspresi 8-oxo-dG dinilai dari pemeriksaan imunohistokimia pada sel epitel mukosa gingiva kelinci. Analisis statistik menggunakan uji korelasi Pearson. Hasil: Peningkatan jumlah mikronukleus paling tinggi terjadi pada hari ke-9 setelah paparan radiografi panoramik. Sementara itu, terdapat korelasi yang signifikan (p=0,049) antara peningkatan jumlah mikronukleus dan ekspresi 8-oxo-dG dengan arah korelasi yang negatif (r=-0,578). Peningkatan jumlah mikronukleus yang terjadi pada hari ke-9 setelah paparan radiografi panoramik ini sesuai dengan penelitian sebelumnya. Dengan bertambahnya hari skor ekspresi 8-oxo-dG semakin menurun. Simpulan: Terdapat korelasi antara jumlah mikronukleus dan skor ekspresi 8-oxo-dG.

Page 2 of 2 | Total Record : 11

 1   2 

Filter by Year

2013 2013


Reset
Filter By Issues
All Issue Vol. 59 No. 1 (2026) Vol. 58 No. 4 (2025): December Vol. 58 No. 3 (2025): September Vol. 58 No. 2 (2025): June Vol. 58 No. 1 (2025): March Vol. 57 No. 4 (2024): December Vol. 57 No. 3 (2024): September Vol. 57 No. 2 (2024): June Vol. 57 No. 1 (2024): March Vol. 56 No. 2 (2023): June 2023 Vol. 56 No. 1 (2023): March 2023 Vol. 56 No. 4 (2023): December Vol. 56 No. 3 (2023): September Vol. 55 No. 4 (2022): December 2022 Vol. 55 No. 3 (2022): September 2022 Vol. 55 No. 2 (2022): June 2022 Vol. 55 No. 1 (2022): March 2022 Vol. 54 No. 4 (2021): December 2021 Vol. 54 No. 3 (2021): September 2021 Vol. 54 No. 2 (2021): June 2021 Vol. 54 No. 1 (2021): March 2021 Vol. 53 No. 4 (2020): December 2020 Vol. 53 No. 3 (2020): September 2020 Vol. 53 No. 2 (2020): June 2020 Vol. 53 No. 1 (2020): March 2020 Vol. 52 No. 4 (2019): December 2019 Vol. 52 No. 3 (2019): September 2019 Vol. 52 No. 2 (2019): June 2019 Vol. 52 No. 1 (2019): March 2019 Vol. 51 No. 4 (2018): December 2018 Vol. 51 No. 3 (2018): September 2018 Vol. 51 No. 2 (2018): June 2018 Vol. 51 No. 1 (2018): March 2018 Vol. 50 No. 4 (2017): December 2017 Vol. 50 No. 3 (2017): September 2017 Vol. 50 No. 2 (2017): June 2017 Vol. 50 No. 1 (2017): March 2017 Vol. 49 No. 4 (2016): December 2016 Vol. 49 No. 3 (2016): September 2016 Vol. 49 No. 2 (2016): June 2016 Vol. 49 No. 1 (2016): March 2016 Vol. 48 No. 4 (2015): December 2015 Vol. 48 No. 3 (2015): September 2015 Vol. 48 No. 2 (2015): June 2015 Vol. 48 No. 1 (2015): March 2015 Vol. 47 No. 4 (2014): December 2014 Vol. 47 No. 3 (2014): September 2014 Vol. 47 No. 2 (2014): June 2014 Vol. 47 No. 1 (2014): March 2014 Vol. 46 No. 4 (2013): December 2013 Vol. 46 No. 3 (2013): September 2013 Vol. 46 No. 2 (2013): June 2013 Vol. 46 No. 1 (2013): March 2013 Vol. 45 No. 4 (2012): December 2012 Vol. 45 No. 3 (2012): September 2012 Vol. 45 No. 2 (2012): June 2012 Vol. 45 No. 1 (2012): March 2012 Vol. 44 No. 4 (2011): December 2011 Vol. 44 No. 3 (2011): September 2011 Vol. 44 No. 2 (2011): June 2011 Vol. 44 No. 1 (2011): March 2011 Vol. 43 No. 4 (2010): December 2010 Vol. 43 No. 3 (2010): September 2010 Vol. 43 No. 2 (2010): June 2010 Vol. 43 No. 1 (2010): March 2010 Vol. 42 No. 4 (2009): December 2009 Vol. 42 No. 3 (2009): September 2009 Vol. 42 No. 2 (2009): June 2009 Vol. 42 No. 1 (2009): March 2009 Vol. 41 No. 4 (2008): December 2008 Vol. 41 No. 3 (2008): September 2008 Vol. 41 No. 2 (2008): June 2008 Vol. 41 No. 1 (2008): March 2008 Vol. 40 No. 4 (2007): December 2007 Vol. 40 No. 3 (2007): September 2007 Vol. 40 No. 2 (2007): June 2007 Vol. 40 No. 1 (2007): March 2007 Vol. 39 No. 4 (2006): December 2006 Vol. 39 No. 3 (2006): September 2006 Vol. 39 No. 2 (2006): June 2006 Vol. 39 No. 1 (2006): March 2006 Vol. 38 No. 4 (2005): December 2005 Vol. 38 No. 3 (2005): September 2005 Vol. 38 No. 2 (2005): June 2005 Vol. 38 No. 1 (2005): March 2005 More Issue