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Dental Journal (Majalah Kedokteran Gigi)
Published by Universitas Airlangga
ISSN : 19783728     EISSN : 24429740     DOI : -
Core Subject : Health,
Dentistry
The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries.
Arjuna Subject : -
Articles 15 Documents
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Search results for , issue "Vol. 58 No. 3 (2025): September" : 15 Documents clear
Ethanol extracts of Rhynchosia nulubilis induce G2/M phase arrest by inducing deoxyribonucleic acid damage in human oral squamous cell carcinoma cells Hwang, Young Sun
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p273-279

Abstract

Background: Early cancer diagnosis is very important for cancer treatment and improvement of patient prognosis, but the development of effective cancer treatment agents is also necessary to overcome cancer. Accordingly, research is being actively conducted to derive ingredients that control cancer progression. Purpose: The antioxidant and anti-inflammatory effects of Rhynchosia nulubilis have been reported in various human cells. We attempted to ascertain the underlying mechanism by which the ethanol extracts of Rhynchosia nulubilis (EERN) induced cytotoxicity and cell cycle arrest in human oral squamous cell carcinoma (OSCC) cells. Methods: The EERN was prepared from the whole Rhynchosia nulubilis. A 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for cytotoxicity of EERN in YD38 OSCC cells. A Matrigel-coated Transwell was used for invasion assay. Changes in the cell cycle distribution were monitored using fluorescence-activated cell sorting analysis. A phosphorylated form of H2AX (γH2AX) foci formation was observed using a fluorescence microscope. Results: Invasion activity of YD38 cells in a Matrigel-coated Transwell was significantly decreased by EERN in a dose-dependent manner. Cytotoxicity was observed at a treatment concentration of 8–10 mg/ml EERN, which induced Transwell invasion inhibition. The YD38 cells were more sensitive to EERN cytotoxicity than immortalized gingival fibroblasts. The EERN treatment arrested the YD38 cell cycle in the G2/M phase, and DNA damage marker γH2AX formation was increased by the EERN treatment. The phosphorylation of ataxia telangiectasia mutated and Chk2 was also increased by EERN treatment. Conclusion: These results indicate that EERN inhibits YD38 cancer cell growth and invasion activity through DNA damage and cell cycle arrest.
Parental awareness of oral health in children with epidermolysis bullosa in Indonesia Azzahra, Rissa Shabira; Dwiyana, Reiva Farah; Diana, Inne Arline; Setiawan, Arlette Suzy
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p249-255

Abstract

Background: Children affected by epidermolysis bullosa (EB) have serious oral conditions that may affect their quality of life. It is the parents’ crucial role to maintain the oral health of children with EB. Purpose: This study aims to determine the crucial role of parents in maintaining the oral health of children with EB. It also aims to assess parents’ oral health knowledge and perceptions of their children’s oral health-related quality of life. Methods: Conducted at Yayasan Dystrophic Epidermolysis Bullosa Research Association, Indonesia, this descriptive study employed a questionnaire translated through cross-cultural adaptation and the Caregiver Perception Questionnaire using a Likert scale. Results: Among the 18 respondents, parental knowledge appeared favorable. Regarding the oral symptoms dimension, 56% of children were in the excellent category, 28% in the moderate category, and 17% in the poor category. In terms of functional limitations, 50% were in the suitable category, 39% were moderate, and 11% were poor. In the emotional state dimension, 78% of participants were in the excellent category, whereas 22% were in the moderate category. In the social conditions dimension, 89% were in the excellent category and 11% in the moderate category. Conclusion: Although parents demonstrated an understanding of oral health care for EB, challenges in implementation emerged.
A dilution method to increase the yield of engineered basic fibroblast growth factor Widyantoro, Indira; Hirata, Isao; Kato, Koichi
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p219-223

Abstract

Background: Genetically engineered chimeric proteins have potential applications as components of dental materials and can be synthesized recombinantly in various cells, including bacteria, yeast, insects and mammals. However, increasing the yields of functionally active products remains a challenge. Purpose: This study focused on basic fibroblast growth factor fused with pentadeca (GGGGS)3 peptide as a linker and hexahistidine as an affinity tag (bFGF-PH). The objective was to enhance the yield of bFGF-PH expressed in bacteria by employing a dilution method. Methods: Escherichia coli was used to express bFGF-PH in a soluble form, which was then purified using metal chelate affinity chromatography. The protein solution was diluted 100-fold with a buffer solution to promote spontaneous refolding. Subsequently, the protein solution was concentrated using metal chelate affinity chromatography. Circular dichroism (CD) spectroscopy was used to analyze the protein’s structure, assessing its correct folding by comparing it to a reference spectrum obtained through computer-based simulation. Results: The dilution method prevented bFGF-PH aggregation, and CD spectroscopy suggested that the protein was correctly folded. As a result, a total of 3.0 mg of bFGF-PH was obtained per liter of lysogeny broth medium, which was higher than the yield achieved using the conventional method. Conclusion: The dilution method examined in this study increased the yield of correctly folded bFGF-PH.
Influence of anxiety and vital signs before dental treatment Pilco-Chicaiza, Joselyn G.; Tubon, Irvin; Salinas-Goodier, Carmen; Dalgo-Flores, Violeta; Vaca-Altamirano, Gabriela L.
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p237-241

Abstract

Background: In the dental field, the anxiety that patients experience before attending a dental appointment is a factor that has increased the rates of oral diseases. This could be because patients visit the dentist less frequently and, in many cases, when they already require specialized treatment. Purpose: The purpose of this research was to determine the levels of anxiety and how they influence the vital signs of patients. Methods: The population consisted of 217 patients who received dental care at a health center and accepted the informed consent provided. The Modified Corah Dental Anxiety Scale (MDAS) was used to determine the level of anxiety. Statistical tests, such as the chi-square test, logistic regression, and odds ratio, were used to determine whether anxiety influences vital signs and dental treatment success. Results: All patients showed anxiety, which was distributed as mild (24.9%), moderate (26.7%), high (7.4%), and severe or phobic (41%). Regarding vital signs, 61.8% of patients presented some alteration in blood pressure, 56.7% had alterations in heart rate, 12.4% showed low oxygen saturation levels, and 24% presented alterations in respiratory rate. Despite these factors, 98.6% of the treatments the patients underwent were successful, and only 1.4% were affected by the influence of anxiety. Conclusion: It was found that the patients presented anxiety at different levels, which affected the typical values of vital signs. However, this situation did not affect the success of the dental treatment.
Oral health promotion on social media: Perceptions of Malaysian young adults Zaberi, Zarikh Hafizah Saqina; Mohd Nor, Nor Azlida; Kamarudin, Yasmin; Kherul Anuwar, Ainol Haniza; Hariyani, Ninuk
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 3 (2025): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i3.p224-230

Abstract

Background: Over the years, social media (SM) has become a powerful tool for communication and health promotion, enabling health professionals to connect with wider audiences in real time. However, there is a lack of qualitative data to understand end users’ perspectives on what is effective and what may require improvement. Purpose: This study aimed to explore preferences, reactions, and perceived impacts of oral health (OH) promotion on SM among Malaysian young adults. Methods: This qualitative study involved in-depth interviews with young adults aged 20–35 years. Purposive sampling was used to ensure diverse representation across several states in Malaysia. Twenty interviews were recorded and transcribed verbatim. Data were coded and analyzed thematically using Atlas.ti software. Three main themes—preferences, reactions, and perceived impacts—and seven sub-themes emerged from the analysis. Results: The young adults expressed positive views regarding OH promotion activities on SM. Most participants preferred visually appealing OH content, such as short videos and infographics, delivered in simple terms in the national language, and presented by health professionals. Although some participants identified as silent readers who did not actively engage with OH-related content, most believed that SM interventions had positively influenced their OH knowledge, attitudes, and behaviors. Conclusion: Most participants had positive perceptions of OH promotion through SM interventions, with some expressing clear content preferences. These findings may support the development of more effective OH promotion strategies in Malaysia that better align with user expectations.

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