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INDONESIA
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES
Published by Universitas Udayana
ISSN : 20854773     EISSN : 23022906     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesia Journal of Biomedical Science (IJBS), Print-ISSN 2085-4773; E-ISSN 2302-2906 is an international and peer-reviewed journal published twice per year in print and online by Indonesian of Biomedical Association in collaboration to Postgraduate School of Biomedicine Udayana University, Bali-Indonesia which was founded in 2007. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of biomedical scholarship, and to encourage a vigorous dialogue between biomedical scholars and researches. The Journal welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and biomedical researchers all over the world.
Arjuna Subject : -
Articles 4 Documents
 1 
Search results for , issue "Vol. 4, No. 2 Juli 2010" : 4 Documents clear
ERGONOMIC INTERVENTION IN ORGANIZATION AND WORK STATION INCREASES STUDENT’S WORK PERFORMANCE AND EFFICIENCY OF ELECTRICAL ENERGY CONSUMPTION Sudiajeng, Lilik; Adiputra, N.; Manuaba, A.; Sutjana, D.P.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 2 Juli 2010
Publisher : Udayana University

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Abstract

Woodworking workshop could be hazardous to workers’ health, particularly when itis done improperly. Workers could be exposed to the following risks such as overexertion,repetitive motion, noise, dust, and chemicals that may threaten workers’ health; decreaseswork inefficiency and excessive strains due to inappropriate working condition or posture.This study was conducted to examine the effect of ergonomics intervention in the students’work performance and the efficiency of the electrical energy consumption at thewoodworking workshop of Bali State Polytechnic.This is an experimental study with pre and post test control group design. Subjectswere divided into 4 groups of students, each consisting of 10 students, all performing thesame task with different working condition: (1) the original working condition for controlgroup (CG); (2) a new organization for treatment group 1 (TG1); (3) a new work station fortreatment group 2 (TG2); and (4) both new organization and work station for treatmentgroup 3 (TG3). Normally distributed and equal data were analyzed by using the One WayAnova test and followed by the Post Hoc–LSD test, and the remaining data were analyzedby using the Kruskal Wallis test and followed by the Mann-Whitney test at the level ofsignificance ? = 0.05.Result showed that students’ work performance in TG1 increased in moderately,while those in TG2 and TG3 increased very considerably. Moreover, there was nosignificant increased of the efficiency of electrical energy consumption in TG1 (p > 0.05),but there were significant increased of electrical energy consumption of about 44.74% and107.89% respectively in TG2 and TG3 (p < 0.05). This gain were accompanied by savingcost of the electrical energy consumption of about 38.64% and 58.68% respectively. It alsoappeared that the increased students’ work performance and the efficiency of electricalenergy consumption were highest in TG3.In conclussion, it may be stated that comprehensive ergonomic intervention in boththe organization and work station in an effort to apply total ergonomic approach hasproduced the best effect in terms of increased students’ work performance and efficiency ofelectrical energy consumption at the woodworking workshop Bali State Polytechnic.
ALDEHYDE DEHIDROGENASE LEVEL AND FATTY ACID ETHYL ESTER AS BIOCHEMICAL MARKERS PERSIST LONGER THAN ETHANOL IN WISTAR RATS AFTER CHRONIC ALCOHOL CONSUMPTION Suaniti, Ni Made; Sudewa Djelantik, A. A. Gde; Suastika, Ketut; Mantik Astawa, Nyoman
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 2 Juli 2010
Publisher : Udayana University

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Abstract

Alcohol consumption in human has increased from year to year in Indonesia and more recently, anincreasing number of cases of alcohol intoxication, alcoholic liver disease, and death were observed.The purpose of this experimental study was to examine the significance of two known biochemicalmarkers of alcohol given by mouth in the Wistar rats. The study design used was the “Truerandomized experimental post test only control group design". The rats were randomly distributedaccording to the experimental design and were treated daily for six weeks (chronic intake) with 5%and 20% alcohol. This study used 15 rats with 5 rats for treatment group treated with 5% alcohol, 5rats for treatment group treated with 20% alcohol, and 5 rats as control group treated with distilledwater. The biochemical markers were aldehyde dehydrogenase (ALDH) and Fatty Acid Ethyl Esters(FAEE). ALDH and FAEE were two biochemical markers of ethanol which are sensitive and specificfor alcohol consumption. The study was conducted in two phases. Initially, rats were treated orallyeveryday for six weeks with 5% and 20% alcohol, and then the blood level of ethanol, ALDH andFAEE were measured. Blood samples were collected at 6 and 24 hours after the last oral intake ofchronic alcohol administration. Qualitative analysis was carried out to detect the presence of ethanol,ALDH, and FAEE in the treatment groups and quantitative analysis to determine their levels in theblood of Wistar rats. Statistical analysis of ALDH was done by using parametric test and the presenceof FAEE persisting longer than ethanol by non-parametric test. The results showed that ALDHpersisted and increased significantly following chronic consumption of alcohol in the rats. Similarly,FAEEs persisted longer than ethanol after alcohol intake. After six hours, the ALDH level increasedby 108.14% in the rat treated chronically with 5% alcohol and by 85.07% in rat treated with 20%alcohol. After 24 hours, FAEE also persisted longer in the blood than ethanol following treatmentwith alcohol 5%. ALDH levels increased by 83.11% after chronic treatment with 5% alcohol and by112.05% in the rats treated with 20% alcohol. In the blood collected 24 hours after the last treatmentwith 5% alcohol, ALDH increased by 95.11% and by 86.79% in the rats treated with 20% alcohol.FAEE persisted longer than ethanol in the blood following administration of 5 % and 20% alcoholboth at 24 hours following chronic treatment. The longer persisting ALDH and FAEE were new andgood biochemical blood markers for chronic alcohol consumption in the Wistar rats.
ERGONOMIC INTERVENTION DECREASES THE LOAD OF LEARNING AND INCREASES THE STUDENTS PERFORMANCES Pungus, Meity; Manuaba, Adnyana; Adiputra, Nyoman; Tirtayasa, Ketut
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 2 Juli 2010
Publisher : Udayana University

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Abstract

Most students’ activities in respect to the implementation of the academic curriculumare done at home. In fact, conventional activity done by the students in boardinghouse ofMinahasa tradition showed unfavorable risks to students based on the load of learning withindicators of musculoskeletal complaints, boredom, and fatigue. Consequently, thestudents were not yet able to attain the intended performance. To overcome the problems,it has made the efforts of ergonomics intervention. In order to test the capability of theergonomics interventions, it had been done a research with the hypothesis, the ergonomicsinterventions on the activity in boardinghouse of Minahasa tradition: normalizes the bodytemperature; decreases the musculoskeletal complaints; decreases the level of boredom;decreases the level of fatigue; increases the accuracy of working; increases the speed ofworking; increases the constancy of working; and increases the results of working of thestudents. This research was done in two periods by utilizing the treatment by subjectdesign. The first and second period was done during four weeks, without and withergonomic intervention. The subjects utilized in the research were as many as 15 persons.The measurements of dependent variables were done before and after doing the activity.The results of the research showed that the ergonomics interventions on the learningactivities in boardinghouse could decrease load of learning significantly (p<0.05): the bodytemperature became normal, the musculoskeletal complaints decreased 44.79%; the levelof boredom decreased 9.79%; the level of fatigue decreased 15.20%; the accuracy ofworking decreased 55.06%; the speed of working decreased 17.32%; the constancy ofworking decreased 30.72%; and the results of working of the students increased 131.44%.It can be concluded that the ergonomics interventions can: decrease the load of learning ofthe students and increase the performance of the students.
HIGH PLASMA TNF-? LEVELS AND MONONUCLEAR CELLS iNOS AND TNF-? EXPRESSION AS RISK FACTORS FOR PAINFUL DIABETIC NEUROPATHY Eko Purwata, Thomas; Suastika, Ketut; Raka Sudewi, A. A.; Widjaja, Djoenaidi
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 2 Juli 2010
Publisher : Udayana University

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Abstract

Painful Diabetic Neuropathy (PDN) is one of the most common and annoyingcomplications of diabetes mellitus. The pathogenesis of PDN is complex and still unclear.Recently it has become clear that nitric oxide (NO) and proinflammatory cytokines playan important role in the pathogenesis and maintenance of pain in PDN. Based on thisphenomenon, this study was conducted to investigate whether the cytokine tumornecrosis factor-alpha (TNF-?) and NO, in this case inducible Nitric Oxide Synthase(iNOS), play a role in PDN pathogenesis.The study was carried in two steps. The first step was a cross sectional and thesecond step was a case-control study. The study was performed in 110 type-2 diabeticpatients. The plasma TNF-? levels were determined by ELISA while the expression ofTNF-? and iNOS in mononuclear cells were analyzed immunohistochemically.Of 110 subjects, 59 patients suffered from Painful DN (case) and the remaining51 patients were Painless DN (control). Cross sectionally, plasma TNF-? levels andimmunoreactivity for iNOS and TNF-? were higher in patients with more severe pain inthe Visual Analog Scale (VAS). There were statistically significant differences (p <0.05) between mild and severe pain in regard to TNF-? level (15.24 pg/ml ± 5.42 vs.20.44 pg/ml ± 10.34 ); to iNOS immunoreactivity (9.72 % ± 8.61 vs. 15.6% ± 11.84); andto TNF-? immunoreactivity (13.0 % ± 9. 48 vs. 20.44% ± 11.75).The case control study showed that TNF-? had an odd ratio of 5.053 [CI 95%(2.241-11.392); p < 0.001]. TNF-? immunoreactivity of 4.125 [CI 95% (1.805-9.425); p< 0.001]; and iNOS immunoreactivity of 3.546 [CI 95% (1.613-7.795); p = 0.002]. There were correlations between TNF-? level, TNF-? and iNOS immunoreactivity andVAS with coefficient correlation: 0.330; 0.285 and 0.275 (p < 0.05) respectively.It is concluded that Diabetic Neuropathy patients with high TNF-? levels, iNOSand TNF-? immunoreactivity of mononuclear cells have higher risk for painful DN thanpainless DN. The higher TNF-? level, iNOS and TNF-? immunoreactivity the moresevere was the pain. This supports the hypothesis that TNF-? and iNOS have role inPDN pathogenesis. The results of this research could be applied as a basic for furtherresearch in pursuit of better management of PDN.

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