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INDONESIA
The Indonesian Biomedical Journal
Published by The Prodia Education and Research Institute
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Public Health
Arjuna Subject : -
Articles 15 Documents
 1   2 
Search results for , issue "Vol 11, No 3 (2019)" : 15 Documents clear
Red Meats and Processed Meat as the Carcinogenic Foods and Phytochemical-chemoprevention Anna Meiliana; Nurrani Mustika Dewi; Andi Wijaya
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.965

Abstract

BACKGROUND: Along with its increased prevalence, in the past decade, cancer had joined the list of chronic debilitating diseases. Nutrition become substantial aspects, due to its time-dependent effect to modulate inflammation thus trigger carcinogenic effects by altering the immune check point. Thus, nutrition contributes to the progression and therapeutic response of cancer, both in human or animal models.CONTENT: Meat is well favored food with appreciable appealing. Due to its high nutritional values it plays a central role in human development. Meat or meat derivate are important sources of proteins, minerals and vitamins. Their nutritional importance is worth compare to their economic impact but recent publication of WHO has set the social alarm about the relationship between red and/or processed meat consumption and cancer. On the other side, some natural or biologic agents may inhibit or reverse tumor growth. Some phytochemical agents including curcumin, resveratrol, lycopene, folates and tea polyphenols clinically proved to tune the signaling pathways regulating cell proliferation and apoptosis in transformed cells, enhance the host immune system and sensitize malignant cells to cytotoxic agents.SUMMARY: Recent studies on chemopreventive agents involves a wide range of molecules, natural (plants, fruits and vegetables) or synthetic will provide better insights for cancer early pathogenesis, important end-point biomarker, and finally potential for reducing the burden of cancer.KEYWORDS: blocking agents, suppressing agents, red meat, processed meat, chemoprevention, phytochemicals
A Comparative Study of Leptin, Oxidant/Antioxidant Status and Some Trace Elements in Women of Healthy Control and Unexplained Infertility in Basrah-Iraq Adnan Jassim Mohammed Al-Fartosy; Nadhum Abdulnabi Awad; Rsha Abdulradha Mahmood
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.915

Abstract

BACKGROUND: To date, there is no study regarding women with unexplained infertility in the province of Basrah, Iraq. This study was conducted to compare the level of leptin, oxidant/antioxidant status, and some trace element levels in women of healthy control and unexplained infertility.METHODS: From total 96 women subjects, 32 subjects had primary unexplained infertility, 31 had secondary unexplained infertility, while 33 fertile women were taken as controls. The body mass index (BMI) of subjects was calculated with standard procedures. The level of fasting serum leptin, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), thyroid-stimulating hormone (TSH), 4-hydroxynonenal (4-HNE), lipid hydroperoxide (LOOH), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and the total antioxidant capacity (TAC) were determined by enzyme-linked immunosorbent assay (ELISA) methods. Magnesium (Mg) and zinc (Zn) were measured by flame, copper (Cu) by flameless atomic absorption spectrometry, while Selenium (Se) in whole blood was determined using hydride generation method.RESULTS: Non-significant changes (p>0.05) were seen in the level of BMI, leptin, TSH, FSH, LH and LH/FSH ratio. Level of 4-HNE, LOOH and Cu were significantly increased (p<0.01), while level of GSH, SOD, CAT, TAC, Se, Zn and Mg were significantly decreased (p<0.01) in primary and secondary type of unexplained infertility, compared to control.CONCLUSION: Serum leptin hormone is significantly associated with BMI and physical activity in both groups. The significant difference in oxidant/antioxidants status between unexplained infertile and fertile women may suggests a possible additional role of oxidative stress mechanisms in pathophysiology of unexplained infertility.KEYWORDS: unexplained infertility, leptin, oxidative stress, antioxidants, trace elements 
Plasma MicroRNA-200c as A Prognostic Biomarker for Epithelial Ovarian Cancer Addin Trirahmanto; Hariyono Winarto; Aria Kekalih; Ferry Sandra
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.761

Abstract

BACKGROUND: Ovarian cancer is the 8th most prevalent cancer in women in the world. Current biomarker prognosis for ovarian cancer has numerous limitations, thus new biomarkers are needed. MicroRNAs (miRs) are considered as potential biomarkers in ovarian cancer as they are stable in blood. One candidate is miR-200c, the main regulator in epithelial transition to the mesenchyme. The aim of this study is to determine the role of miR-200c as prognostic biomarker for epithelial ovarian cancer (EOC).METHODS: This is a prospective cohort study conducted at Dr. Sardjito Central General Hospital in Yogyakarta from September 2015 to July 2018. Sampling was done using consecutive sampling method. Forty plasma samples of EOC subjects were included in this study. miR-200c expression was quantified using Reverse Transcriptase Quantitative Quantitative Polymerase Chain Reaction (RTqPCR) with miR-16 as the reference gene.RESULTS: The expression of miR-200c was significantly higher in the group of subjects with preoperative CA-125 levels >500 U/mL (p=0.009) than the group of subjects with preoperative CA-125 levels <500 U/mL. Subjects with higher miR-200c expression had lower survival rate than subjects with lower miR-200c expression, although not statistically significant.CONCLUSION: The miR-200c could be a promising biomarker for EOC. Further studies with larger sample sizes are needed to clarify the prognostic value of miR200c.KEYWORDS: miR-200c, epithelial ovarian cancer, prognosis, overall survival
Comparison of Tumor Necrosis Factor-α Level in Coronary Artery Disease and Coronary Slow Flow of Thrombolysis in Myocardial Infarction Muhammad Diah; Rahmawati Rahmawati; Aznan Lelo; Zulfikri Muhktar; Dharma Lindarto; Ferry Sandra
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.826

Abstract

BACKGROUND: Tumor necrosis factor (TNF)-α, an important primary pro-inflammatory cytokine, has a crucial role in the pathogenesis of atherosclerosis. Since the pathophysiological mechanism of coronary slow flow (CSF) is not fully understood, we investigated the level of TNF-α in coronary artery disease (CAD), CSF and healthy subjects.METHODS: This study was conducted in cross-sectional design involving 16 CAD, 18 CSF and 18 healthy subjects. Coronary angiography was recorded at the left anterior oblique, cranial, right anterior oblique, caudal, and horizontal positions. The flow in coronary arteries of the subjects were assessed using Thrombolysis in the Myocardial Infarction (TIMI) frame count method. Peripheral blood-derived serum was collected and level of TNF-α was determined by using highly sensitive enzymelinked immunosorbent assay (ELISA).RESULTS: No significant difference in level of TNF-α in CAD, CSF and healthy subjects (2.72±2.64 pg/mL, 1.88±0.8 pg/mL, 1.64±0.35 pg/mL, respectively) (p=0.087). In addition, there was no correlation between the concentration of TNF-α and TIMI frame count (r<0.2, p>0.05).CONCLUSION: There was no significant difference of TNF-α level in CAD, CSF and healthy subjects. In addition, there was no correlation between the TNF-α level with TIMI frame count as well. Nevertheless, further clinical studies with more subjects are needed.KEYWORDS: TNF-alpha, coronary artery disease, coronary slow flow 
Protective Effect of Curcumin on Quality Parameters of Sperm and Testicular Tissue Alterations in Alloxan-induced Diabetic Rats as Animal Model Damoon Sadoughi; Mohammad Amin Edalatmanesh; Raheleh Rahbarian
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.733

Abstract

BACKGROUND: Type one diabetes mellitus (DM) is a multisystem disorder whose effects are observed in the reproductive system. Considering the role of curcumin in lowering blood glucose and enhancing antioxidant defense, this research aimed to determine protective effect of curcumin on quality parameters of sperm and testicular tissue alterations in diabetic rats.METHODS: Forty male Wistar rats were randomly divided into five groups, including control (healthy rats), DM (for diabetic model), and also curcumin-treated diabetic model (DM+CUR)50, DM+CUR100 and DM+CUR150. Diabetes was induced using an intraperitoneal injection of 240 mg/ kg alloxan. Following completion of the test period, all rats were sacrificed, and their testes were removed to assess sperm parameters and histological evaluation. The data was analyzed with one-way ANOVA and Tukey post hoc test. The p<0.05 was set as the significance level.RESULTS: Concentration, total sperm motility (TMot), progressive sperm motility (PMot), average path velocity (VAP), curvilinear velocity (VCL), straight line velocity (VSL) of sperm in DM+CUR100 and DM+CUR150 were significantly increased (p=0.005) compared to the diabetic group. Mean diameter (p=0.004) and thickness of the germline epithelium of testis semeniferous tubules (p=0.005) in DM+CUR100 and DM+CUR150 significantly increased compared to the diabetic group.CONCLUSION: It can be concluded that curcumin plays a protective role in testicular tissue alterations and improves sperm parameters. In this regard, curcumin could be suggested to be one of the natural antioxidants that can improve fertility in diabetic patients.KEYWORDS: diabetes mellitus, curcumin, spermatozoa, testis, rats

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