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All Journal Media Ilmu Keolahragaan Indonesia The Indonesian Biomedical Journal Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Majalah Kedokteran Nusantara The Journal Of Medical School Sumatera Medical Journal PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) The Journal of Society Medicine (JSOCMED)

Aznan Lelo

Department Of Phannacology, University Of North Sumatera Medical School/H. Adam Malik Hospital, Medan, North Sumatera

Author-ID : 305688

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 9 Documents Claim Missing Document

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Articles

Hubungan Koloni Pseudomonas Aeruginosa dengan Persentase Split Take Thickness Skin Graft (STSG) Pada Pasien Luka Bakar Di RSUP H. Adam Malik Medan Nst, Roni Marzuki; Buchari, Frank Bietra; Tarigan, Utama; Lelo, Aznan
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 3 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pendahuluan Luka bakar masih merupakan masalah global. Insiden luka bakar di seluruh dunia pada tahun 2004 diperkirakan 1,1 per 100.000 penduduk. Dan hampir separuh terjadi di wilayah Asia Tenggara. Skin graft digunakan dalam berbagai situasi klinis termasuk rekonstruksi luka bakar. ). Patogen yang paling umum yang menyebabkan kegagalan graft adalah coagulase positive staphylococcus, Pseudomonas dan beta-haemolytic Streptococcus. Oleh karena itu, peneliti perlu meneliti hubungan koloni Pseudomonas aeruginosa dengan tingkat keberhasilan skin graft pada pasien luka bakar di RSUP H. Adam Malik Medan.Metode Penelitian ini merupakan penelitian descriptive analitik dengan desain penelitian crossectional, dilakukan di Departemen Ilmu Bedah Plastik RSUP H. Adam Malik Medan selama periode Februari sampai Juni 2014. Populasi dalam penelitian ini adalah seluruh penderita luka bakaryang dirawat di RSUP H. Adam Malik Medan pada kurun waktu Februari sampai Juni 2014 yang dilakukan skin graft.Hasil Dari 22 kasus luka bakar dijumpai persentase take skin graft > 80% pada 16 pasien (72.7%), persentase take skin graft antara 50-80% pada 5 pasien (22.7%), dan persentase take skin graft < 50% dijumpai pada 1 pasien. take skin graft >80% pada luka bakar dengan Pseudomonas aeroginosa dijumpai pada 3/7 kasus (42,86%) yang lebih sedikit pada luka bakar non Pseudomonas aeroginosa yaitu pada 13/15 kasus (86,67%). Take <80% pada penderita luka bakar dengan Pseudomonas aeroginosa ( 4/7 = 57.14% ) lebih banyak dari pada luka bakar dengan non Pseudomonas aeroginosa ( 2/15 = 13,33% ). Namun perbedaan ini secara statistik hampir bermakna (p=0,073).Kesimpulan Tingkat keberhasilan skin graft sebesar >80% pada luka bakar dengan Pseudomonas aeroginosa dijumpai pada 3/7 kasus (42,86%) yang lebih sedikit pada luka bakar non Pseudomonas aeroginosa yaitu pada 13/15 kasus (86,67%). Berdasarkan uji chi square tidak dijumpai adanya hubungan koloni Pseudomonas aeruginosa dengan tingkat keberhasilan skin graft pada penderita luka bakar (p=0,073)Kata Kunci Pseudomonas Aeruginosa, Split Take Thickness Skin Graft (STSG), Luka Bakar

The Effect of Torbangun Leaves Tea on Msg-induced Fetal Develop-ment Disorder in Mice M.Kes, Sufitni; Feriyawati, Lita; Pane, Yunita Sari; Lelo, Aznan
Sumatera Medical Journal Vol. 2 No. 1 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

The safety of MSG on the fetus has not been confirmed yet. The objective of this research is to determine the effect of tea of torbangun leaves on fetal development disorder of mice. The present study is experimental with a Completely Randomized Design (CRD). Data obtained were then analyzed by ANOVA, with p<0,05 as the level of significant. The comparison of mean values ± SEM increase number of live fetuses group C1-T1 (4,60 ± 0,93; 11,40 ± 0,87), p=0,018. The comparison of mean values ± SEM decrease number of embryo re-sorption percentage group C0-C1 (00,00 ± 00,00; 36,74 ± 15,13), group C1-C2 (36,74 ± 15,13; 00,00 ± 0,00), group C1-T1 (36,74 ± 15,13; 00,00 ± 0,00), and group C1-T2 (36,74 ± 15,13; 15,00 ± 22,36), p=0,020. This study concluded that T1 group is giving the best effect on increasing life fetuses and decreasing embryo re-sorption percentage.

Salat Dhuha Improves Blood Pressure: A Randomized Controlled Trial Boy, Elman; Lelo, Aznan; Tarigan, Amira Permatasari; Machrina, Yetty; Yusni, Yusni; Harahap, Juliandi; Sembiring, Rosita Juwita; Syafril, Santi; Sumartiningsih, Sri
Media Ilmu Keolahragaan Indonesia Vol 11, No 2 (2021): December 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/miki.v11i2.34225

The prevalence of hypertension increases with age, more than 1 in every two elderly has hypertension, dominated by women. The primary prevention of hypertension is a worldwide public health concern. Salat dhuha is a moderate-intensity physical activity. Salat 2 movement cycles demonstrated improved systolic and diastolic blood pressure in adults. Our study purpose was to assess the effect of 2 and 8 movement cycles (rakaat) of salat dhuha to improve systolic and diastolic blood pressure in healthy Muslim elderly women. Muslim elderly women in a government senior residence (aged 60-74 years) participated in a 6 weeks controlled trial. We completed formal physical, clinical, and blood assessments before admission. Participants with hypertension history were excluded. The participants were randomized into 2 groups. The intervention group performed 8 rakaat of salat dhuha (n=13) and the control group performed 2 rakaat of salat dhuha (n=13). Two participants were dropped out of this study. At baseline and at the end of 6 weeks, a blood pressure examination is recorded. Parametric and nonparametric methods were used to analyze the data. The baseline characteristics of the two groups of participants were homogeneous. Compared to the control, the 8 rakaat of salat dhuha achieved a significant reduction in systolic and diastolic blood pressure (P0.05) at the end of the 6-weeks period. The findings show that salat dhuha has significant potential to improve blood pressure.

Comparison of Tumor Necrosis Factor-α Level in Coronary Artery Disease and Coronary Slow Flow of Thrombolysis in Myocardial Infarction Muhammad Diah; Rahmawati Rahmawati; Aznan Lelo; Zulfikri Muhktar; Dharma Lindarto; Ferry Sandra
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.826

BACKGROUND: Tumor necrosis factor (TNF)-α, an important primary pro-inflammatory cytokine, has a crucial role in the pathogenesis of atherosclerosis. Since the pathophysiological mechanism of coronary slow flow (CSF) is not fully understood, we investigated the level of TNF-α in coronary artery disease (CAD), CSF and healthy subjects.METHODS: This study was conducted in cross-sectional design involving 16 CAD, 18 CSF and 18 healthy subjects. Coronary angiography was recorded at the left anterior oblique, cranial, right anterior oblique, caudal, and horizontal positions. The flow in coronary arteries of the subjects were assessed using Thrombolysis in the Myocardial Infarction (TIMI) frame count method. Peripheral blood-derived serum was collected and level of TNF-α was determined by using highly sensitive enzymelinked immunosorbent assay (ELISA).RESULTS: No significant difference in level of TNF-α in CAD, CSF and healthy subjects (2.72±2.64 pg/mL, 1.88±0.8 pg/mL, 1.64±0.35 pg/mL, respectively) (p=0.087). In addition, there was no correlation between the concentration of TNF-α and TIMI frame count (r<0.2, p>0.05).CONCLUSION: There was no significant difference of TNF-α level in CAD, CSF and healthy subjects. In addition, there was no correlation between the TNF-α level with TIMI frame count as well. Nevertheless, further clinical studies with more subjects are needed.KEYWORDS: TNF-alpha, coronary artery disease, coronary slow flow

Riboflavin as migraine prophylaxis in adolescents Athaillah Athaillah; Yazid Dimyati; Johannes H. Saing; Bistok Saing; Hakimi Hakimi; Aznan Lelo
Paediatrica Indonesiana Vol 52 No 3 (2012): May 2012
Publisher : Indonesian Pediatric Society

Background Migraine is a cause of recurrent headaches inchildren. Riboflavin has been sho\Vll to be efficacious in preventingmigraine in adults. However, there has been little research on itsuse in children and adolescents.Objective To assess the effectiveness of riboflavin for migraineprevention in adolescents.Methods We conducted a randomized, doubleô€…blind, controlledtrial in the Islamic Centre of the Musthafav.iyah Mandailing NatalDistrict, North Sumatera, from May to July 2010. Adolescents\\lith migraines, as defined criteria, were included. Subjects were divided into two groups,receiving either 400 mg of riboflavin or placebo for 3 months.Headache frequency was measured in headache days per month,headache duration was measured in hours, and functionaldisability was measured using the Pediatric Migraine DisabilityAssessment Scale (PedMIDAS). Migraines were assessed before,during and after intervention. Student's tô€…test was used forstatistical analysis.Results A total of 98 patients, ranging from 12 to 19 years inage (mean age 14.0 years) were enrolled. We found a significantreduction in headache frequency in the second and third months.Headache duration also differed significantly third months (P=0.012 and P=O.OOl, respectively). Riboflavindecreased disability, as indicated by lower PedMIDAS scores inthe riboflavin group compared to the placebo group (26.1 and34.3, respectively, P= 0.001).Conclusion Riboflavin effectively decreased migraine frequency,duration and disability in adolescents. [Paediatr Indones.2012;52:132-7].

The addition of omeprazole to ondansetron for treating chemotherapy-induced nausea and vomiting in pediatric cancer patients Perjuangan Dapot Hamonangan Simbolon; Selvi Nafianti; Pertin Sianturi; Bidasari Lubis; Aznan Lelo
Paediatrica Indonesiana Vol 58 No 1 (2018): January 2018
Publisher : Indonesian Pediatric Society

Background Chemotherapy-induced nausea and vomiting are some of the most disturbing side effects in pediatric cancer patients. The standard recommendation is the use of 5-hydroxytryptamine 3 receptor antagonist, such as ondansetron, to treat these symptoms. Despite this treatment, more than 50% of patients still experience nausea and vomiting. Objective To evaluate the effect of the addition of omeprazole to ondansetron in the treatment of chemotherapy-induced nausea and vomiting. Methods A double-blind, randomized, controlled trial was conducted at Haji Adam Malik Hospital, Medan, North Sumatera, from March to May 2016. Subjects were children aged 1 to 18 years, diagnosed with cancer, and who received intravenous chemotherapy. Patients were randomized to receive either a single dose of ondansetron (0.5 mg/kg) plus placebo or ondansetron (0.5 mg/kg) plus omeprazole (0.5 mg/kg). The severity of nausea and vomiting were measured using the Rhodes index of nausea, vomiting, and retching during the 24 hours after initiation of emetogenic chemotherapy. The primary outcome of efficacy was the proportion of patients who achieved complete response (lack of nausea/vomiting). Statistical analysis was performed by Chi-square and Fischerâ€™s exact tests. Results Seventy eligible pediatric patients were randomized into two groups: 32 subjects in the ondansetron + placebo group and 38 others in the ondansetron + omeprazole group. The therapy failed in 50% (16/32) of the ondansetron + placebo group and 18.4% (7/38) of the ondansetron + omeprazole group. There was a significant difference in the clinical response between groups (P=0.01). Conclusion The addition of omeprazole to ondansetron for the treatment of chemotherapy-induced nausea and vomiting is more effective than administration of ondansetron alone.

Intravenous and Oral Paracetamol Have the Same Effect in Reducing Fever in Pediatric Patients Fitri Asymida; Yazid Dimyati; Bidasari Lubis; Aznan Lelo; Muhammad Ali; Ayodhia Pitaloka Pasaribu; Syahril Pasaribu
Molecular and Cellular Biomedical Sciences Vol 4, No 3 (2020)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v4i3.147

Background: The antipyretic effect of intravenous versus oral paracetamol is not well known. This study was aimed to compare the antipyretic effect of intravenous and oral paracetamol therapy to reduce fever.Materials and Methods: This was an open-label randomized clinical trial study. The subjects were children who presented to Pediatric Ward and Emergency of Haji Adam Malik Hospital, aged from 2 months to 18 years old, with axillary temperature ≥38.0ºC. Subjects were divided into two groups, group 1 received 15 mg/kg paracetamol intravenous and group 2 received the same dose of paracetamol but given through intravenous. The temperature reduction was analyzed by ANOVA, and the change in temperature was recorded at 0, 15, 30, 60, 120, and 180 minutes after drug administration.Results: In the first group, the mean temperature was decreased (p<0.001) from 15 to 180 minutes after the administration of paracetamol. Nausea was documented as the adverse effect for both oral and intravenous administration groups.Conclusion: The administration of 15 mg/kg paracetamol, either though intravenous or oral, have similar effect in reducing fever in children. Paracetamol therapy though intravenous route can be given if it cannot be given orally.Keywords: antipyretic, pediatrics, fever, intravenous, oral, paracetamol

CATECHOL-O-METHYLTRANSFERASE (COMT) ENZYME LEVELS IN PATIENTS WITH PREOPERATIVE ANXIETY Hamongan Nasution, Akhyar; Lelo, Aznan
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 1 (2022): JANUARY
Publisher : Transpublika Publisher

The preoperative anxiety’s incidence is very high and mostly preoperative patients have anxiety. It was found that low COMT levels indicate a tendency to develop anxiety. Hence, this study aims to investigate COMT enzyme levels in patients with preoperative anxiety. This research is a purely experimental research with a pretest-posttest control group design and double-blind. Measurement of COMT enzyme levels was executed by utilizing ELISA technique. Blood samples were taken from preoperative anxiety patients who were assessed with the Amsterdam Preoperative Anxiety Information Scale (APAIS). The research was carried out at Haji Adam Malik General Hospital and Regional General Hospital dr. Pirngadi Medan, and Integrated Laboratory of the Faculty of Medicine, University of North Sumatra. The were 64 samples involved in this research that fit the inclusion and exclusion criteria. The findings show that COMT levels in the anxiety and control groups had differences with p values = 0.014. In addition, COMT levels in the preoperative anxiety group were lower when compared to those without the preoperative anxiety group, where in the anxiety group had COMT enzyme levels of 0,14 ± 0,08 ng/dl, while in the control group had higher COMT levels 0,96 ± 1,11 ng/dl. The results showed that patients with preoperative anxiety had lower levels of the COMT enzyme compared to patients without preoperative anxiety. Researchers suspect there is a role for the COMT enzyme in causing preoperative anxiety.

Catechol-O-Methyltransferase (COMT) Enzyme Level In Preoperative Anxiety Patients Hamonangan Nasution, Akhyar; Lelo, Aznan
Journal of Society Medicine Vol. 1 No. 1 (2022): October
Publisher : CoinReads Media Prima

Background: Incidence of perioperative anxiety is very high, many preoperative patient experience anxiety . Thiamine acts as an essential nutrition funtionate as cofactor enzyme in most of mitochondria in brain. Brain is very susceptible to thiamine deficiency because its dependency on mitochondrial ATP production. Decreased ATP production result in inhibition of COMT activity. Low COMT levels indicated tendency for anxiety. The aim of this study is to determine the effect of thiamine in increasing COMT enzyme levels in patient with preoperative anxiety Methods : A true experiment with pretest-posttest control group and double-blind design conducted at the Department of Anesthesia and Intensive Care of University of North Sumatra in August 2019. The 60 patients were analyzed which were planned for and done an elective surgery under general anesthesia. Preoperative anxiety was measured with Amsterdam Preoperative Anxiety and Information Scale (APAIS) and COMT enzyme level measured by ELISA assays. Results : The results showed that from 64 patients had incidence of preoperative anxiety in this study was 48.3%. We found that there is significant differences in COMT enzyme levels in thiamine group compared to control (p value = 0.001). In addition, it was seen that in thiamine group had an increased COMT levels from 0.96 ng/dL to 1.78 ng/dL, while in control group there also slight increasing from 0.44 ng/dL to 0.78 ng/dL. This show that increase in COMT levels is greater in thiamine group than control group. Conclusion : Thiamine can cause increasing COMT enzyme levels in patients scheduled for elective surgery with preoperative anxiety under general anesthesia

Co-Authors Abdul R. Rahman Abdul Rasyid Athaillah Athaillah Ayodhia Pitaloka Pasaribu Bidasari Lubis Bidasari Lubis Bistok Saing Buchari, Frank Bietra dharma Lindarto, dharma ELMAN BOY Feriyawati, Lita Ferry Sandra Fitri Asymida Hakimi Hakimi Hamonangan Nasution, Akhyar Hamongan Nasution, Akhyar Harahap, Juliandi Johannes H. Saing Kamaruddin Jaalam Muhammad Ali Muhammad Diah Nst, Roni Marzuki Perjuangan Dapot Hamonangan Simbolon Pertin Sianturi Rahmawati Rahmawati Santi Syafril, Santi Selvi Nafianti Sembiring, Rosita Juwita Sri Sumartiningsih Sufitni Syahril Pasaribu Tarigan, Amira Permatasari Tarigan, Utama Yazid Dimyati Yazid Dimyati Yetty Machrina Yunita Sari Pane Yusni Yusni Zulfikri Muhktar

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