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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Indonesian Journal of Herbal Science and Innovation
Nursamsiar
Universitas Almarisah Madani
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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Evaluation of α-Glucosidase Inhibitor Activity of Ethanol Extract of Soursop Leaf (Annona muricata L.) Nursamsiar; Anjas Kila; Fitriyanti Jumaetri Sami
Indonesian Journal of Herbal Science and Innovation Vol. 1 No. 1 (2025): Indonesian Journal of Herbal Science and Innovation
Publisher : PT CENDEKIA SCIENCE AND TECHNOLOGY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64673/ijherbsi.v1i1.4

Abstract

Soursop (Annona muricata L.) is a plant widely used in traditional medicine, where people typically consume soursop leaf infusions or supplements to help regulate blood sugar levels. This plant contains several bioactive compounds, including flavonoids, quercetin, tannins, alkaloids, fatty acids, phytosterols, morinol alcohol, and annonol. Among these, flavonoids, quercetin, and tannins are suspected to have antidiabetic properties. In recent years, interest has increased in the potential of natural products, especially plant extracts, as alternative therapeutic agents for managing diabetes, particularly through the inhibition of α-glucosidase, an enzyme involved in carbohydrate digestion and glucose absorption. Despite the widespread use of soursop, there is limited scientific evidence evaluating its α-glucosidase inhibitory activity. This research aims to assess the potential of ethanol extract of soursop leaves (Annona muricata L.) as an α-glucosidase inhibitor using a microplate reader. In this study, the inhibition of α-glucosidase was determined by the enzymatic reaction between α-glucosidase and the substrate p-nitrophenyl-α-D-glucopyranoside (PNPG), measured spectrophotometrically using a microplate reader. The results of the study indicate that the ethanol extract of soursop leaves exhibited moderate inhibition of α-glucosidase, with an IC50 value of 764.14 µg/mL. While the extract demonstrated some inhibitory potential, it was less potent compared to standard α-glucosidase inhibitors. These findings suggest that although the ethanol extract of soursop leaves has α-glucosidase inhibitory activity, it may require further optimization or combination with other compounds to enhance its effectiveness. This research contributes to the growing body of evidence regarding the antidiabetic properties of soursop and provides insights into its potential as a functional food or herbal supplement for managing diabetes.
Studi In Silico Jatropon, Jatropolon A, Jatropolon B, dan Turunan Sebagai Anti Kanker Terhadap Reseptor Bcl-2 Ramanda R Syaifullah; Muhammad Sholeh; Wafiq Azizah; Nur F Kasman; Nursamsiar; Andi Paluseri; Lukman
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64761

Abstract

Jatrophone and its congeners jatropholone A and B, have shown potent cytotoxicity by triggering apoptosis through Bcl-2–regulated mechanisms. We evaluated jatrophone, jatropholones A and B and twenty-two related derivatives as Bcl-2–targeting anticancer leads using in silico approaches. Molecular properties and preliminary affinity estimates were obtained with ChemOffice; molecular docking to the Bcl-2 binding site was performed with AutoDock Tools. ADME predictions used PreADMET and toxicity risk assessment applied Toxtree with the Benigni/Bossa rule-base. Twelve compounds violated Lipinski’s rule of five, while thirteen displayed identical amino-acid contacts at the receptor, suggesting a conserved binding mode. Predicted plasma protein binding was high for most derivatives except compounds 20 and 22. Six derivatives were flagged as potentially genotoxic; none were predicted mutagenic. Docking ranked jatropholone A as the top candidate (binding energy −8.67 kcal/mol). These results prioritize jatropholone A for experimental validation as a promising Bcl-2–targeting anticancer agent.
Co-Authors Andi Paluseri Anjas Kila Fitriyanti Jumaetri Sami Lukman Muhammad Sholeh Nur F Kasman Ramanda R Syaifullah Wafiq Azizah