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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JURNAL KESEHATAN YAMASI MAKASSAR
Andi Paluseri
universitas almarisah madani
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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KNOWLEDGE OF DRUG MANAGEMENT OFFICERS AND DRUG AVAILABILITY AT PRIMARY HEALTH CENTERS IN MAKASSAR CITY Andi Paluseri; yuniati; Lukman Lukman
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/e10wv796

Abstract

Adequate drug availability at primary health centers (Puskesmas) is a key indicator of effective drug management and may be influenced by the knowledge of drug management officers. This study aimed to examine the relationship between officers’ knowledge and drug availability at selected Puskesmas in Makassar City. A descriptive analytical observational study with a cross-sectional design was conducted on May 16–17, 2025, at Paccerakkang, Mamajang, Pattingalloang, and Mangasa Puskesmas, which were selected using cluster random sampling. All eligible drug management officers were included through total sampling, resulting in seven respondents. Knowledge was assessed using a 20-item questionnaire with excellent reliability (Cronbach’s alpha = 0.9675), while drug availability was evaluated using 2024 Drug Usage and Request Reports (LPLPO) for 40 indicator drugs. Data were analyzed using the Shapiro–Wilk normality test and Pearson’s correlation test. The mean knowledge score was 90%, categorized as good; six respondents had good knowledge and one had sufficient knowledge. Drug availability varied across facilities: one Puskesmas was categorized as good (69.87%), while three were categorized as sufficient, with an average availability of 46.29%. Pearson’s correlation showed no significant relationship between officers’ knowledge and drug availability (r = -0.853; p = 0.147). These findings suggest that drug availability is likely influenced more by procurement policies, distribution systems, and health budget allocation than by officers’ knowledge alone.
Studi In Silico Jatropon, Jatropolon A, Jatropolon B, dan Turunan Sebagai Anti Kanker Terhadap Reseptor Bcl-2 Ramanda R Syaifullah; Muhammad Sholeh; Wafiq Azizah; Nur F Kasman; Nursamsiar; Andi Paluseri; Lukman
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64761

Abstract

Jatrophone and its congeners jatropholone A and B, have shown potent cytotoxicity by triggering apoptosis through Bcl-2–regulated mechanisms. We evaluated jatrophone, jatropholones A and B and twenty-two related derivatives as Bcl-2–targeting anticancer leads using in silico approaches. Molecular properties and preliminary affinity estimates were obtained with ChemOffice; molecular docking to the Bcl-2 binding site was performed with AutoDock Tools. ADME predictions used PreADMET and toxicity risk assessment applied Toxtree with the Benigni/Bossa rule-base. Twelve compounds violated Lipinski’s rule of five, while thirteen displayed identical amino-acid contacts at the receptor, suggesting a conserved binding mode. Predicted plasma protein binding was high for most derivatives except compounds 20 and 22. Six derivatives were flagged as potentially genotoxic; none were predicted mutagenic. Docking ranked jatropholone A as the top candidate (binding energy −8.67 kcal/mol). These results prioritize jatropholone A for experimental validation as a promising Bcl-2–targeting anticancer agent.
Co-Authors Lukman Muhammad Sholeh Muslimin, Lukman Nur F Kasman Nursamsiar Ramanda R Syaifullah Wafiq Azizah yuniati