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All Journal African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Arts, Humanities and Religious Studies African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Akafa, Tensaba Andes
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Effect of Administration of Copper plasma Activated water and Anesthetic on Hematological and Pancreatic tissues of Wister rats Umaru, Isaac John; Kingsly, Iseko Iyoko; Gyasi, Prince Kwadwo; Ogochukwu, Edom Favour; Akafa, Tensaba Andes; Malantso, Jackson Soyinka; Habibu, Bilyaminu; Umaru, Kerenhappuch Isaac
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 1 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i1.4722

Abstract

In biomedicine, applications of PAW span from biofilm removal, wound healing, deactivation of bacteria and viruses, dentistry (for teeth disinfection and whitening), and cancer therapy. The biochemical activity of PAW is derived from synergistic effects of the highly reactive species, specifically reactive oxygen and nitrogen species (RONS). PAW is considered a biofriendly and prospective solution for biotechnology applications due to the time dependent nature of its biochemical activity because of the active species, and its economic and environmental benefits of using air rather than toxic chemicals as the raw material. Thus, the study on Effect of Administration of Copper plasma Activated water and Anaesthetic on Haematological and Pancreatic tissues of Wister rats. Material and Methods: Preparation of plasma-activated water a non-thermal micro-hollow cathode discharge (MHCD) was used to generate plasma-activated waters (CU-PAWs). Results: The results showed the haematological profile of the animals treated with 400mgkg-' had a decrease in Haemoglobin, Mean capsular Haemoglobin (11.21 ± 1.23 and 22.93 ± 21.11) compared to the controlled group (15.03 ± 1.72 and 29.93 ± 7.27) and in animals treated with 200mgkg-1 and 400mgkg-1 there is a significant decrease in the platelets (21.96 ± 23.16 and 20.89 ± 24.03) compared to animals on control group (32.08± 16.70) (table 2). Animals treated with 200mgkg-' and 400mgkg-' have a decrease in platelet (22.36 ± 4.88 and 20.89 ± 24.03) compared to animals on control (32.08 ± 16.70) and also animals treated with 400mgkg-1 have an elevated white blood cell count 173-56 ± 4.50) compared to the control group (3.66 ± 3.06). Conclusion: Cupper plasma water is safe to be used since it do not have much effect on the blood biochemistry and haematological parameters unlike the aesthetic agents cause changes on the haematological and blood biochemistry parameters. Hence, it is important to be aware of the effects of these agents before using them in experiments.
Effect of Aqueous Extract of Achyranthes aspera Leaves on Antiretroviral Drug-Induced Hepatotoxicity in Rats Umaru, Isaac John; Udoh, Mary Athanasius; Akafa, Tensaba Andes; Oteng, Joseph; Akem, Ingwu Joseph; Ngbede, Ocheifa Mathew; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Ekup, Ogholo Ogholo
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5183

Abstract

Achyranthes aspera leaves are believed to reverse drug resistance and increase the efficacy of current drugs. Achyranthes aspera leaves contain many secondary metabolites needed for the redressal of diseases and ailment. Thus, the ART-induced hepatotoxicity in rats. Methodology: Thirty (30) albino rats were divided into 5 groups of 6 each and treated as follows: Group A (no antiretroviral drugs, no extract); group B (antiretroviral drugs alone); group C (extract alone); group D (antiretroviral drug plus 40 mg/kg extract); group E (antiretroviral drug plus 80 mg/kg extract). All treatment lasted for twenty-eight days. Blood samples were collescted and serum ALT and AST determined using UV-spectrophotometer. The mean (± S.E.M) of data were calculated and further analysed for statistical significance using graph Pad Prism 5.0. Results: Mean serum ALT were 36.8 ± 20.24, 56.11 ± 6.12, 54.6 ± 24.18, 90.40 ± 11.14, 88.36 ± 13.10 and that of AST were 143.8 ± 20.24, 208.4 ± 16.13, 60.0 ± 24.18, 164.40 ± 11.14, 52.36 ± 16.14 for groups A, B, C, D, and E respectively. There was a statistically significant difference between the mean values of serum AST for group B and those for group C. However, there was no statistically significant difference between the ALT values for the test and control groups of rats (p value >0.999) Also, there was no statistically significant difference between the mean values of AST for group B and those of groups A, D, E. Conclusions: This extract at a higher concentration should add to the treatment of HIV in synergy with antiviral drugs, However, the extract shown no significant reduction of serum ALT and AST in ART treated rats.
Co-Authors Abdulrasheed, Lubabatu Acha, Ozzioma Praise Agaba, Eric Agim Akafa, Ranyang R. Akafa, Vika Tensaba Akam, Odok Endurance Akem, Ingwu Joseph Akem3, Ingwu Joseph Ametsi, Smile Kobina Asare, Solomon Ossom Ayara, Charles Bafai, Favour Joel David, Izam Emmanuel Dennis, Adobeni Emmanuel Ekup, Ogholo Ogholo Eli, Isaac Kogi Enang, Kingsley Bassey Gadin, Ndentang Ira Gyasi, Prince Kwadwo Habibu, Bilyaminu Hassan, Okrah George Ihaji, Elvis O. Iseko, Kingsley Iyoko Istifanus, Dafup Katdel John, Artu Ishishen John, Tongle Nanle Kingsly, Iseko Iyoko Konka, Daniel Makanjuola, Victor Malantso, Jackson Soyinka Mark, Akaninyene Mijinyawa, Aboki Nwunuji Muoghallu, Obianuju Iheomamere Nanmar, Chakfa Ngbede, Ocheifa Mathew Ngbede, Ocheifa Matthew Ogochukwu, Edom Favour Okwori, Ameh Godwin Oladele, Gloria Omonefe Oteng, Joseph Tahidu, Issifu Tyem, Lawal Danjuma Udoh, Mary Athanasius Uduak, Peter Ise Ujah, Oche Williams Ujah, Williams Oche Umaru, Isaac John Umaru, Kerenhappuch Isaac Utioukpan, Ashaka Fidelis Williams, Queen Uyo Yuguda, Ismail Yunusa Zakariah, Danladi