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Anti-Inflammatory and Anti-Microbial Effects of Prosopis Africana Methanol Stem Back Extract Aduwamai, Umaru Hauwa; Oluwatosin, Jegede Olosola; Malgwi, Jemimah Mohammed; Umaru, Kerenhappuch Isaac
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3732

The anti-inflammatory and anti-microbial effect of Prosopis Africana methanol stem bark extract was determined. Results of qualitative phytochemical screening revealed the presence of tannins, saponins, flavonoids, alkaloids, phenols, steroids and terpenoids. The quantitative analysis revealed the quantity of alkaloids (0.11%), tannins (1.92%), phenols (3.77%), flavonoids (0.77%), steroids (0.14%), terpenoids (0.21%) and saponins (4.01%). The anti-inflammatory effect of methanol stem-bark extract of Prosopis africana was assessed in male albino rats using paw immersion method. The anti-inflammatory effect produced by methanol stem-bark extract of Prosopis africana was found to be significant (p<0.05) at the dose of 200mg/kg, which was more effective than other concentrations at time interval of 0-90minutes. The antimicrobial activities of the methanol stem-bark extract of Prosopis africana produced the highest zone of inhibition (l7mm) on Pseudomonas aeruginosa and the lowest zone of inhibition (11mm) on Staphylococcus aureus. The minimum inhibitory concentration value of Prosopis Africana methanol stem-bark extract against E.coli, S. aureus and P. areuginosa was 2.5mg/ml each compared to K. pneumonia which was 5.5mg/ml. Results obtained indicate the antimicrobial effect of the methanol stem-bark extract of Prosopis Africana against K. pneumoniae was more effective than ampicillin. This work has further supported the basis for the use of the plant as anti-inflammatory agent in the treatment of various diseases associated with the microorganisms studied.

The Effect of Punica granatum Leaf Tea on Potassium Oxonate Induced Gout in Male Wistar Rats Wonderful, Akinniyi Ezekiel; Aduwamai, Umaru Hauwa
African Journal of Biochemistry and Molecular Biology Research Vol 3 No 2 (2026): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v3i2.9479

Gout is a prevalent and debilitating inflammatory condition caused by the deposition of monosodium urate crystals in the joints, leading to acute pain, swelling, and redness. This study aimed to evaluate the effect of Punica granatum leaf tea on potassium oxonate-induced gout in male Wistar rats. Thirty rats were allocated into six groups of five animals each, and gout was induced by intraperitoneal administration of potassium oxonate at 250 mg/kg body weight for 14 days. P. granatum leaf tea was administered at doses of 10, 20, and 30 mg/kg body weight. The findings showed that potassium oxonate significantly increased serum uric acid, creatinine, IL-1β, IL-6, TNF-α, and hepatic xanthine oxidase activity relative to the normal control. Among the tested doses, 30 mg/kg body weight produced a significant (p < 0.05) reduction in uric acid (4.80 ± 0.06 mg/dL vs. 7.37 ± 0.15 mg/dL), IL-1β (25.41 ± 0.79 pg/mL vs. 31.45 ± 2.71 pg/mL), and hepatic xanthine oxidase activity (5.93 ± 0.20 U/L vs. 11.89 ± 1.11 U/L), with effects comparable to the standard drug group. The same dose also showed a more pronounced effect than the standard drug in reducing TNF-α (7.44 ± 0.58 pg/mL vs. 10.95 ± 1.87 pg/mL) and ALP (63.16 ± 2.06 U/L vs. 68.00 ± 1.98 U/L). The study concludes that Punica granatum leaf tea exhibits anti-hyperuricemic, anti-inflammatory, and organ-protective effects in potassium oxonate-induced gout, highlighting its potential contribution as a natural therapeutic candidate for gout management.

Anti-Inflammatory and Anti-Microbial Effects of Prosopis Africana Methanol Stem Back Extract Aduwamai, Umaru Hauwa; Oluwatosin, Jegede Olosola; Malgwi, Jemimah Mohammed; Umaru, Kerenhappuch Isaac
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3732

The anti-inflammatory and anti-microbial effect of Prosopis Africana methanol stem bark extract was determined. Results of qualitative phytochemical screening revealed the presence of tannins, saponins, flavonoids, alkaloids, phenols, steroids and terpenoids. The quantitative analysis revealed the quantity of alkaloids (0.11%), tannins (1.92%), phenols (3.77%), flavonoids (0.77%), steroids (0.14%), terpenoids (0.21%) and saponins (4.01%). The anti-inflammatory effect of methanol stem-bark extract of Prosopis africana was assessed in male albino rats using paw immersion method. The anti-inflammatory effect produced by methanol stem-bark extract of Prosopis africana was found to be significant (p<0.05) at the dose of 200mg/kg, which was more effective than other concentrations at time interval of 0-90minutes. The antimicrobial activities of the methanol stem-bark extract of Prosopis africana produced the highest zone of inhibition (l7mm) on Pseudomonas aeruginosa and the lowest zone of inhibition (11mm) on Staphylococcus aureus. The minimum inhibitory concentration value of Prosopis Africana methanol stem-bark extract against E.coli, S. aureus and P. areuginosa was 2.5mg/ml each compared to K. pneumonia which was 5.5mg/ml. Results obtained indicate the antimicrobial effect of the methanol stem-bark extract of Prosopis Africana against K. pneumoniae was more effective than ampicillin. This work has further supported the basis for the use of the plant as anti-inflammatory agent in the treatment of various diseases associated with the microorganisms studied.

The Effect of Punica granatum Leaf Tea on Potassium Oxonate Induced Gout in Male Wistar Rats Wonderful, Akinniyi Ezekiel; Aduwamai, Umaru Hauwa
African Journal of Biochemistry and Molecular Biology Research Vol 3 No 2 (2026): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v3i2.9479

Gout is a prevalent and debilitating inflammatory condition caused by the deposition of monosodium urate crystals in the joints, leading to acute pain, swelling, and redness. This study aimed to evaluate the effect of Punica granatum leaf tea on potassium oxonate-induced gout in male Wistar rats. Thirty rats were allocated into six groups of five animals each, and gout was induced by intraperitoneal administration of potassium oxonate at 250 mg/kg body weight for 14 days. P. granatum leaf tea was administered at doses of 10, 20, and 30 mg/kg body weight. The findings showed that potassium oxonate significantly increased serum uric acid, creatinine, IL-1β, IL-6, TNF-α, and hepatic xanthine oxidase activity relative to the normal control. Among the tested doses, 30 mg/kg body weight produced a significant (p < 0.05) reduction in uric acid (4.80 ± 0.06 mg/dL vs. 7.37 ± 0.15 mg/dL), IL-1β (25.41 ± 0.79 pg/mL vs. 31.45 ± 2.71 pg/mL), and hepatic xanthine oxidase activity (5.93 ± 0.20 U/L vs. 11.89 ± 1.11 U/L), with effects comparable to the standard drug group. The same dose also showed a more pronounced effect than the standard drug in reducing TNF-α (7.44 ± 0.58 pg/mL vs. 10.95 ± 1.87 pg/mL) and ALP (63.16 ± 2.06 U/L vs. 68.00 ± 1.98 U/L). The study concludes that Punica granatum leaf tea exhibits anti-hyperuricemic, anti-inflammatory, and organ-protective effects in potassium oxonate-induced gout, highlighting its potential contribution as a natural therapeutic candidate for gout management.

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