Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal International Journal of Health, Engineering and Technology
Miela Agustin
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Review Of Natural Compounds And Medicinal Chemistry Approaches In Drug Development Amin, Saeful; Hilna Putri Herlina; Wulandari Wulandari; Miela Agustin
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.844

Abstract

The increasing prevalence of degenerative and infectious diseases has encouraged the development of more effective, selective, and safer therapeutic agents. Natural compounds and medicinal chemistry approaches have demonstrated considerable potential in modern drug discovery due to their diverse pharmacological activities and structural complexity. This study aims to review the role of bioactive   natural compounds and computational approaches in contemporary drug development. The method employed was a literature review based on recent scientific publications discussing medicinal chemistry, molecular docking, quantitative structure–activity relationship analysis, artificial intelligence-assisted drug design, and nanoformulation strategies. The findings indicate that several natural compounds, particularly flavonoids and quercetin, exhibit promising anticancer, antidiabetic, antioxidant, and antibacterial activities through interactions with various biological targets. Computational approaches such as molecular docking, virtual screening, predictive modeling, and deep QSAR were shown to improve the efficiency of lead identification and molecular optimization. Furthermore, nanoformulation systems contribute to enhancing bioavailability, molecular stability, and therapeutic effectiveness of bioactive compounds. Despite these advantages, challenges including compound complexity, ADMET limitations, and the necessity for experimental validation remain important considerations in drug development. In conclusion, the integration of natural compounds, medicinal chemistry, and computational technologies provides significant opportunities for accelerating and optimizing modern drug discovery and development.
Co-Authors Hilna Putri Herlina Saeful Amin, Saeful Wulandari Wulandari