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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. International Journal of Health, Engineering and Technology
Ikhwan Handirosiyanto
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Effectiveness of Petai (Parkia speciosa) Ethanol Extract in Controlling Foam Cell Numbers in Atherosclerosis-Induced Male Wistar Rats Ikhwan Handirosiyanto; Indra setiawan; Seftiana Khaerun Nisa; Dian Yuliartha Lestari
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 20 No. 1 (2024): June 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol20.SMUMM1.38652

Abstract

Atherosclerosis is a chronic inflammatory disease that causes the narrowing of the arterial lumen, and it is considered the primary cause of cardiovascular diseases such as myocardial infarction (MI), heart failure, and stroke. Cardiovascular disease is the leading of death globally. Atherosclerosis has a complex pathophysiology, such as endothelial dysfunction, thickening of the tunica intima, and the formation of atheromatous plaques. After that process, foam cells will form, which is the key to the development of atherosclerosis. Petai ethanol extract contains antioxidants, which are flavonoids, saponins, and tannins, that can reduce the number of Low-Density lipoproteins (LDL). The purpose of this study was to evaluate the effect of petai ethanol extract on the number of atherosclerotic foam cells in male white rats (Rattus norvegicus strain wistar) induced by lard. The method of this study was a genuinely experimental and post-test-only control group design with 25 rats divided into five control groups, which are one negative control group, one positive control group, and three treatment groups with extract doses of 100mg/kgBW, 200mg/kgBW and 400mg/kgBW. Observation of foam cells was carried out using a microscope with 400x magnification. Data were analyzed using Oneway ANOVA and Post Hoc Tamhane's test. The results of the study using the Oneway ANOVA test showed that there were significant differences between groups (p: 0.000). Post Hoc Tamhane's test between the positive control group and treatment groups 1, 2, and 3 can be seen that there is a significant difference between the formation of foam cells due to the administration of petai ethanol extract compared to positive control (p <0.05). This study concludes that Petai ethanol extract was effective in reducing the number of atherosclerotic foam cells formed.
Effectiveness Test of Ethanol Extract of Petai (Parkia speciosa) on the Number of Atherosclerotic Foam Cells in Male Wistar Rats (Rattus norvegicus strain Wistar) Atherosclerosis Model Ikhwan Handirosiyanto; Seftiana Khaerun Nisa; Indra Setiawan; Dian Yuliartha Lestari
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.714

Abstract

Atherosclerosis is a chronic inflammatory disease that causes narrowing of the arterial lumen and is a dominant cause of cardiovascular diseases such as myocardial infarction (MI), heart failure, and stroke. Cardiovascular disease itself is the leading cause of death worldwide. Atherosclerosis has a complex pathophysiology, starting from endothelial dysfunction, thickening of the tunica intima, and the formation of atheromatous plaques. During its progression, foam cells are formed, which play a key role in the development of atherosclerosis. The ethanol extract of petai (Parkia speciosa) contains compounds such as flavonoids, saponins, and tannins that function to reduce the levels of Low-Density Lipoprotein (LDL). The purpose of this study was to determine the effectiveness of petai ethanol extract in reducing the number of atherosclerotic foam cells formed in male Wistar rats (*Rattus norvegicus strain Wistar) induced by lard. This study used a true experimental method with a post-test only control group design. A total of 25 rats were divided into five groups: one negative control group, one positive control group, and three treatment groups receiving petai ethanol extract at doses of 100, 200, and 400 mg/kg body weight. The formation of foam cells was observed using a microscope with 400× magnification. Data were analyzed using the One-Way ANOVA test and Post Hoc Tamhane’s test. The results of the One-Way ANOVA test showed a significant difference among the groups (p = 0.000). The Post Hoc Tamhane’s test between the positive control group and treatment groups 1, 2, and 3 indicated significant differences in foam cell formation due to the administration of petai ethanol extract compared to the positive control group (p < 0.05). In conclusion, the administration of petai ethanol extract was effective in reducing the number of atherosclerotic foam cells formed.
Co-Authors Dian Yuliartha Lestari Indra Setiawan Indra Setiawan Seftiana Khaerun Nisa Seftiana Khaerun Nisa