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All Journal Journal of Pharmaceutical and Sciences.
Puteri Rahma Maharani
Universitas Singaperbangsa Karawang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Perbandingan Aktivitas Antioksidan Senyawa Flavonoid dari Ekstrak Daun Kelor (Moringa Oleifera L.) Menggunakan Metode Spektrofotometri Uv-Vis Puteri Rahma Maharani; Izmi Haura Syahida; Munir Alinu Mulki
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.677

Abstract

The bioactive compounds found in moringa leaves (Moringa oleifera L.) can function as natural antioxidants to protect cells from damaging free radicals. The purpose of this study is to ascertain the antioxidant activity of moringa leaves according to the type of solvent, analyze the relationship between antioxidant capacity and concentration of active compounds, and determine the best solvent. Extraction was carried out using ethanol, methanol, and aquades solvents, followed by testing antioxidant activity using UV-Vis spectrophotometry method on DPPH radicals. The content of phenols, flavonoids, and tannins in the extract was measured to understand their contribution to antioxidant activity Based on the results of the study, the extract containing ethanol solvent showed the most powerful antioxidant activity, with an IC50 value of 103.98 ppm. In conclusion, the type of solvent has a significant effect on the antioxidant activity of moringa leaves, with ethanol solvents being the most effective option. This research strengthens the potential of moringa leaves as a natural source of antioxidants that can be utilized for applications in the pharmaceutical and health fields, although further research is needed to optimize extraction techniques and the development of moringa oleifera leaf-based product
Interaksi Warfarin dan Aspirin terhadap Risiko Perdarahan pada Pasien Penderita Penyakit Kardiovaskular Firli Reisya Subekti; Zahra Nurhafidah; Jasmine Rahma Saputri; Adhwa'a Kaylla; Jahra Almas Shadrina; Puteri Rahma Maharani; Mukarromah Dita Putri; Hadi Sudarjat; Indah Laily Hilmi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1196

Abstract

Background: Cardiovascular disease (CVD) remains a leading cause of global morbidity and mortality; therefore, antithrombotic therapy such as warfarin and aspirin plays a crucial role in preventing thromboembolic events. The combination of these two agents provides a synergistic effect in inhibiting thrombus formation but significantly increases the risk of bleeding. Objective: To evaluate the impact of concominant ose of warfarin and aspirin on bleeding risk and its clinical benefits in patients with CVD. Methods: A systematic literature search was conducted using Google Scholar and Pubmed, with eligible studies analyzed. Result: The concomitant use of warfarin and aspirin increases the incidence of major bleeding without providing additional benefits in preventing stroke or myocardial infarction. Moreover, poor anticoagulation control further exacerbates this risk. Conclusion: The combination of warfarin and aspirin should be reserved only for patients with strong clinical indications, while warfarin monotherapy is safer for those with stable conditions. These findings emphasize the importance of individualized therapy evaluation and optimal INR monitoring to balance therapeutic benefits and bleeding risks.
Co-Authors Adhwa'a Kaylla Firli Reisya Subekti Indah Laily Hilmi Izmi Haura Syahida Jahra Almas Shadrina Jasmine Rahma Saputri Mukarromah Dita Putri Munir Alinu Mulki Sudarjat, Hadi Zahra Nurhafidah