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All Journal Journal of Pharmaceutical and Sciences.
Mukarromah Dita Putri
Universitas Singaperbangsa Karawang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Interaksi Warfarin dan Aspirin terhadap Risiko Perdarahan pada Pasien Penderita Penyakit Kardiovaskular Firli Reisya Subekti; Zahra Nurhafidah; Jasmine Rahma Saputri; Adhwa'a Kaylla; Jahra Almas Shadrina; Puteri Rahma Maharani; Mukarromah Dita Putri; Hadi Sudarjat; Indah Laily Hilmi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1196

Abstract

Background: Cardiovascular disease (CVD) remains a leading cause of global morbidity and mortality; therefore, antithrombotic therapy such as warfarin and aspirin plays a crucial role in preventing thromboembolic events. The combination of these two agents provides a synergistic effect in inhibiting thrombus formation but significantly increases the risk of bleeding. Objective: To evaluate the impact of concominant ose of warfarin and aspirin on bleeding risk and its clinical benefits in patients with CVD. Methods: A systematic literature search was conducted using Google Scholar and Pubmed, with eligible studies analyzed. Result: The concomitant use of warfarin and aspirin increases the incidence of major bleeding without providing additional benefits in preventing stroke or myocardial infarction. Moreover, poor anticoagulation control further exacerbates this risk. Conclusion: The combination of warfarin and aspirin should be reserved only for patients with strong clinical indications, while warfarin monotherapy is safer for those with stable conditions. These findings emphasize the importance of individualized therapy evaluation and optimal INR monitoring to balance therapeutic benefits and bleeding risks.
Tinjauan literatur: Evaluasi Kepatuhan Terapi Obat Pada Pasien Diabetes Melitus 2 Menggunakan Media edukasi Booklet Diyanah Fauziyah Tamimah; Mukarromah Dita Putri; Elsyifa Salsabila
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1154

Abstract

Type 2 diabetes mellitus is a chronic disease that requires long-term treatment and continuous management, with its prevalence increasing in Indonesia. Patient adherence to treatment is crucial for effective disease control. This article explains that the use of booklets as educational media can play an important role in improving treatment adherence among patients with type 2 diabetes. A Systematic Literature Review was conducted following the PRISMA guidelines by searching PubMed and Google Scholar for articles published between 2015 and 2025. The findings show that booklets are effective when used independently or in combination with other educational methods; however, combining them with direct education from healthcare professionals yields more optimal results in improving adherence. Factors such as age, educational level, family support, and ease of access to information influence the success of this intervention. Booklets are superior to other educational media because they can be reread, provide comprehensive information, and are affordable without requiring advanced technology. The results indicate that booklets are an effective and valuable educational tool to enhance treatment adherence among patients with type 2 diabetes mellitus. Therefore, it is recommended that they be incorporated into chronic disease management strategies in primary healthcare facilities.
Pengaruh Berbagai Bentuk Intervensi Apoteker terhadap Kepatuhan Pengobatan dan Kualitas Hidup Pasien Rawat Jalan Skizofrenia : Narrative Review Annisa Sambada; Mukarromah Dita Putri; Noviani Ayu Mulyati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1204

Abstract

Schizophrenia is a global issue with a significant increase in recurrence, affecting approximately 23 million people or 1 in every 345 individuals worldwide, with recurrence rates increasing from 28% in 2019 to 54% in 2021[2]. This narrative review examined the literature from 2015–2024 from PubMed and Google Scholar with inclusion criteria of pharmacist interventions in outpatient schizophrenia patients, the use of assessment instruments such as MARS, PANSS, and WHOQOL-BREF, and the reporting of quantitative outcomes related to adherence and quality of life. Seven studies that met the criteria showed that pharmacist counseling can significantly improve medication adherence. In the Si-Care model, adherence rates increased from 77.38% to 97.57% (an increase of 20.19%; p = 0.000). Higher effectiveness was seen in longer-duration interventions, interactive methods such as home visits, and implementation involving collaboration with psychiatrists, which also supported improvements in quality of life. However, variations in study design resulted in diverse findings, and single-session interventions tended to be less optimal than ongoing support. Without counseling, adherence rates remained low, at around 65%. Overall, the available evidence confirms the benefits of pharmacist counseling, but further research is needed to standardize intervention models and evaluate the long-term impact on outpatients with schizophrenia.
Co-Authors Adhwa'a Kaylla Annisa Sambada Diyanah Fauziyah Tamimah Elsyifa Salsabila Firli Reisya Subekti Indah Laily Hilmi Jahra Almas Shadrina Jasmine Rahma Saputri Noviani Ayu Mulyati Puteri Rahma Maharani Sudarjat, Hadi Zahra Nurhafidah