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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Insan Farmasi Indonesia
Izza Aulia Rizqika Nasution
Program Studi Farmasi, Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau, Pekanbaru
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

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AKTIVITAS SITOTOKSIK EKSTRAK ETIL ASETAT DAUN AKAR KAIK-KAIK (Uncaria cordata (Lour.) Merr) PADA SEL KANKER SERVIKS HeLa Noveri Rahmawati; Nur Annisya Ulfa; Izza Aulia Rizqika Nasution; Nurdina Putri
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v9i1.2817

Abstract

Cervical cancer is one of the leading causes of death in women worldwide and is a highly prevalent disease in developing countries. Efforts to prevent and treat cervical cancer continue to be developed, one of which is through the use of natural ingredients that have anticancer activity. This study aims to determine the cytotoxic activity of ethyl acetate extracts of Kaik-Kaik root leaves (Uncaria cordata (Lour.) Merr) against HeLa cervical cancer cells in vitro. Kaik-Kaik root leaves were extracted using a stepwise maceration method with n-hexane, ethyl acetate, and methanol solvents. The ethyl acetate extract was then tested for its cytotoxic activity using the MTT assay at various concentrations. Phytochemical screening results showed the presence of secondary metabolites such as flavonoids, tannins, saponins, and terpenoids that play a role in biological activity. Cytotoxicity test results showed that the ethyl acetate extract had very strong potential with an IC₅₀ value of 0.524 μg/mL, which is classified as highly toxic to cancer cells. These findings indicate that Uncaria cordata has the potential to be developed as a herbal-based anticancer agent. This study is expected to contribute to the development of safer, more effective, and more affordable alternative therapies for cervical cancer patients.
Hipertensi sebagai Prediktor Luaran Klinis pada Pasien COVID-19 pasien Rawat Inap: Studi di Rumah Sakit Achmad Mochtar Najmi Hilaliyati; Reza Laila Najmi; Efilia Meirita; Izza Aulia Rizqika Nasution; Fitratul Wahyuni; Resi Rizki Banjarani
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.7009

Abstract

Populations with comorbidities, especially hypertension, are susceptible to COVID-19 infection and are known to be at risk of increasing disease severity, increasing the risk of poor clinical outcomes, and high mortality. There is no specific therapy to treat this disease, but several types of antivirals have been developed. The purpose of this study was to study the impact of comorbidities and antiviral therapy on clinical outcomes in the form of a length of stay and vital signs (pulse, respiratory rate, temperature, and oxygen saturation) of COVID-19 patients with or without comorbid hypertension. The study was conducted with a cross-sectional design. Data were collected retrospectively through the medical records of 80 patients who met the inclusion criteria and were treated during the period April 2020–March 2021 at Bukittinggi Hospital. Data were analyzed using the Mann-Whitney U Test, Kruskal Wallis Test, Friedman Test, and Repeated Measures Anova. The results showed that comorbidity had a significant impact on the patient's respiratory rate (p<0.05). The administration of different antivirals in patients with or without comorbid hypertension had a significant impact on the length of stay, body temperature, and oxygen saturation of patients (p<0.05). Patients receiving favipiravir therapy showed a shorter length of stay than the antivirals Oseltamivir, Ramdesivir and Hydroxychloroquine.
Co-Authors Efilia Meirita Fitratul Wahyuni Najmi Hilaliyati Noveri Rahmawati Nur Annisya Ulfa Nurdina Putri Resi Rizki Banjarani Reza Laila Najmi