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All Journal Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Tri Diana Puspita Rini
Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Islam Sultan Agung, Semarang, Jawa Tengah, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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ANALISIS JEJARING FARMAKOLOGI DAUN TEMBELEKAN (Lantana camara L.) TERHADAP ANTI LUKA BAKAR Tri Diana Puspita Rini; Wardah Salsabila Rafli; Rissa Maharani Dewi; Meki Pranata
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/p32xd546

Abstract

Burn injuries are skin lesions that can cause tissue damage, infection, and impaired regeneration if not properly treated. Lantana camara L. leaves are known to contain various secondary metabolites with potential wound-healing properties. This study aimed to analyze the anti-burn potential of Lantana camara using a network pharmacology approach. Computational analyses were performed using the KNApSACK, SwissADME, SwissTargetPrediction, GeneCards, STRING-DB, Cytoscape–CytoHubba, and ShinyGO 0.77 databases. A total of 39 secondary metabolites were identified, all of which fulfilled Lipinski’s Rule of Five, indicating good potential oral bioavailability. Protein target analysis revealed 305 intersecting proteins between metabolite targets and burn-related proteins. Network analysis identified AKT1 as the main hub protein, followed by TNF, IL6, STAT3, BCL2, HIF1A, and EGFR. The major biological pathways involved included the PI3K/Akt and HIF-1 signaling pathways, which regulate cell proliferation, angiogenesis, anti-apoptosis, and hypoxia response. In addition, positive regulation of peptidyl-serine phosphorylation was identified as the dominant biological process associated with inflammation regulation and tissue regeneration. These findings suggest that Lantana camara has strong potential as an anti-burn agent through a multitarget mechanism that supports tissue healing.
JEJARING FARMAKOLOGI DAUN UBI JALAR (Ipomoea batatas L.) SEBAGAI PENYEMBUHAN LUKA BAKAR Tri Diana Puspita Rini; Wa Ode Fefen Nurmalah
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 12 No. 1 (2026): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v12i1.970

Abstract

Burns are complex tissue injuries involving inflammation, oxidative stress, and cell death, requiring effective and safe therapy. Sweet potato leaves (Ipomoea batatas L.) are known to contain bioactive compounds such as flavonoids and polyphenols, which have potential as wound healing agents. This study aims to identify the molecular mechanisms of active compounds from sweet potato leaves in burn wound healing using a network pharmacology approach. The research methods included identification of active compounds through the KNApSAcK database and literature, structure verification using PubChem, and drug-likeness analysis using SwissADME based on Lipinski’s rules. Protein target prediction was performed using SwissTargetPrediction, while disease targets were obtained from GeneCards. Protein-protein network analysis (PPI) was performed using STRING and visualization with Cytoscape. Gene Ontology and KEGG pathway analysis were then performed. The results showed 29 active compounds with 231 target proteins that overlapped with burn injury genes. Topological analysis identified key proteins such as STAT3, IL6, AKT1, and CASP3. GO and KEGG analyses revealed the involvement of inflammatory pathways, oxidative stress, and tissue proliferation and regeneration. These findings suggest that sweet potato leaves have potential as a burn wound healing agent through an integrated multi-target mechanism.
Co-Authors Meki Pranata Rissa Maharani Dewi Wa Ode Fefen Nurmalah Wardah Salsabila Rafli