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All Journal Jurnal Insan Farmasi Indonesia
safwan safwan
Department of Pharmacy, Faculty of Medicine, Mataram University, Mataram 83125 Indonesia.
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics

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Metabolit Antibakteri dari Aspergillus nidulans DSP 20, Jamur Endofit Mangrove Asosiasi Sesuvium portulacastrum safwan safwan; Baiq Desti Isnanda Maolia; Yuli Fitriana; Abdul Rahman Wahid; Widayatul Khairi
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/safz8j78

Abstract

Mangrove-associated endophytic fungi are promising producers of antibacterial secondary metabolites. This study evaluated the potential of Aspergillus nidulans DSP 20, isolated from leaves of Sesuvium portulacastrum collected from the Sekotong mangrove-associated ecosystem, as a producer of antibacterial metabolites. The isolate was obtained through surface sterilization of leaf tissue, colony purification, and morphological characterization. Metabolite production was performed by 21-day solid-state fermentation followed by ethyl acetate extraction. The metabolite profile was qualitatively analyzed using thin-layer chromatography, while antibacterial activity was tested against Staphylococcus aureus and Escherichia coli using the disc diffusion method. DSP 20 showed morphological characteristics supporting its identification as A. nidulans, produced an ethyl acetate extract with several chromatographic spots, and formed inhibition zones against both test bacteria. These findings indicate that A. nidulans DSP 20 is a potential preliminary source of antibacterial metabolites from mangrove-associated endophytic fungi.
Co-Authors Abdul Rahman Wahid Baiq Desti Isnanda Maolia Widayatul Khairi Yuli Fitriana