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All Journal Journal of Food and Pharmaceutical Science Jurnal Insan Farmasi Indonesia Journal of Food and Pharmaceutical Sciences
Eka Kumalasari
Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Banjarmasin, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics

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PROFIL FINGERPRINTING KLT DAN PENENTUAN AKTIVITAS PENANGKAL RADIKAL BEBAS (DPPH) FRAKSI METANOL, ETIL ASETAT, DAN N-HEKSAN DAUN DADANGKAK (Hydrolea spinosa L.) Dwi Rizki Febrianti; Desy Ayu Lestari PRAMUDITO; Rakhmadhan Niah PRAMUDITO; Eka Kumalasari; Inderiyani; Novia Ariani; Subagus Wahyuono; Siska Musiam
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v9i1.3022

Abstract

Dadangkak leaves (Hydrolea spinosa L.) contain various secondary metabolites with potential antioxidant activity. This study aimed to evaluate the thin-layer chromatography (TLC) fingerprinting profile and antioxidant activity of the n-hexane, ethyl acetate, and methanol fractions of Dadangkak leaf extract. Extraction was performed using ethanol followed by fractionation based on solvent polarity. Compound profiling was analyzed by TLC under UV light at 254 and 366 nm using several spray reagents. Antioxidant activity was assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method with UV-Vis spectrophotometric measurement at 517 nm to determine IC₅₀ values. The results demonstrated that the methanol fraction exhibited the most comprehensive chromatographic profile, showing positive responses to all spray reagents, indicating a higher diversity of secondary metabolites compared with the other fractions. All fractions showed free radical scavenging activity against DPPH radicals. The IC₅₀ values were 0.110 ppm for the n-hexane fraction, 0.245 ppm for the ethyl acetate fraction, and −1.588 ppm for the methanol fraction. Furthermore, the methanol fraction showed the highest coefficient of determination (R²), indicating the strongest linear relationship between concentration and inhibition percentage. These findings suggest that the methanol fraction possesses the greatest potential as a natural antioxidant source.
Formulation and Evaluation of Liquid Soap Containing Ethanolic Extract of Eleutherine palmifolia (L.) Merr. Leaves Erna Prihandiwati; Nur Ainah; Muhammad Ma'ruf; Senya Puteri Amalia; Eka Kumalasari; Muhammad Aulia Irwansyah; Olivia Olivia
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.30088

Abstract

Eleutherine palmifolia (L.) Merr is a native plant of South Kalimantan with considerable potential for health applications. Previous studies have reported that its leaves contain various bioactive compounds, including alkaloids, flavonoids, steroids, tannins, and saponins, which contribute to antibacterial and antioxidant activities. Liquid soap is one of the most practical and widely used dosage forms for antibacterial purposes. Therefore, this study aimed to formulate and evaluate the physical characteristics of liquid soap containing ethanol extract of E. palmifolia leaves and to determine the optimal formulation that meets quality standards. An experimental study was conducted using three formulations with different concentrations of Cocamide DEA (0.5%, 1%, and 1.5%). The formulations consisted of E. palmifolia leaf extract, virgin coconut oil (VCO), potassium hydroxide (KOH), Na-CMC, stearic acid, BHT, lemongrass oil, and distilled water. The prepared liquid soaps were evaluated for pH, viscosity, foam stability, storage stability, hedonic properties, antibacterial activity, and irritation potential. The results showed that Formula 2 containing 1% Cocamide DEA exhibited the most favorable overall characteristics, providing a balance between physical stability, user comfort, and respondent acceptance. Formula 3 produced the highest foam stability but caused a dry sensation on the skin. Furthermore, Formula 2 containing 1.5% E. palmifolia extract demonstrated strong inhibitory activity against Staphylococcus aureus and moderate inhibitory activity against Escherichia coli. All formulations met the required quality parameters and showed no irritation effects. In conclusion, liquid soap formulated with 1% Cocamide DEA and 1.5% E. palmifolia leaf extract was identified as the optimal formulation. The conclusion of the results of this product meets the requirements of SNI 06-4085-1996, exhibited good physical stability, was non-irritating, and showed potential as a natural antiseptic liquid soap.
Formulation and Evaluation of Liquid Soap Containing Ethanolic Extract of Eleutherine palmifolia (L.) Merr. Leaves Erna Prihandiwati; Nur Ainah; Muhammad Ma'ruf; Senya Puteri Amalia; Eka Kumalasari; Muhammad Aulia Irwansyah; Olivia Olivia
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.30088

Abstract

Eleutherine palmifolia (L.) Merr is a native plant of South Kalimantan with considerable potential for health applications. Previous studies have reported that its leaves contain various bioactive compounds, including alkaloids, flavonoids, steroids, tannins, and saponins, which contribute to antibacterial and antioxidant activities. Liquid soap is one of the most practical and widely used dosage forms for antibacterial purposes. Therefore, this study aimed to formulate and evaluate the physical characteristics of liquid soap containing ethanol extract of E. palmifolia leaves and to determine the optimal formulation that meets quality standards. An experimental study was conducted using three formulations with different concentrations of Cocamide DEA (0.5%, 1%, and 1.5%). The formulations consisted of E. palmifolia leaf extract, virgin coconut oil (VCO), potassium hydroxide (KOH), Na-CMC, stearic acid, BHT, lemongrass oil, and distilled water. The prepared liquid soaps were evaluated for pH, viscosity, foam stability, storage stability, hedonic properties, antibacterial activity, and irritation potential. The results showed that Formula 2 containing 1% Cocamide DEA exhibited the most favorable overall characteristics, providing a balance between physical stability, user comfort, and respondent acceptance. Formula 3 produced the highest foam stability but caused a dry sensation on the skin. Furthermore, Formula 2 containing 1.5% E. palmifolia extract demonstrated strong inhibitory activity against Staphylococcus aureus and moderate inhibitory activity against Escherichia coli. All formulations met the required quality parameters and showed no irritation effects. In conclusion, liquid soap formulated with 1% Cocamide DEA and 1.5% E. palmifolia leaf extract was identified as the optimal formulation. The conclusion of the results of this product meets the requirements of SNI 06-4085-1996, exhibited good physical stability, was non-irritating, and showed potential as a natural antiseptic liquid soap.
Co-Authors Desy Ayu Lestari PRAMUDITO Erna Prihandiwati Febrianti, Dwi Rizki Inderiyani Muhammad Aulia Irwansyah Muhammad Ma'ruf Novia Ariani Nur Ainah Olivia Olivia Rakhmadhan Niah PRAMUDITO Senya Puteri Amalia Siska Musiam Subagus Wahyuono