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All Journal Jurnal Ilmu Kefarmasian Indonesia Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks
Ayuningtyas, Dhyan Kusuma
Bandung Institute Of Technology
Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Medicine & Pharmacology Public Health Social Sciences Other

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Cardioprotective Potential of Ethanol Extract of Sonchus Arvensis L. Leaves on Isoproterenol-Induced Myocardial Infarction in Rat Neng Fisheri Kurniati; Elin Yulinah Sukandar; Rian Pardilah; Nova Suliska; Dhyan Kusuma Ayuningtyas
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1805.662 KB) | DOI: 10.35814/jifi.v16i1.434

Abstract

Sonchus arvensis L. leaves have been used traditionally to treat various disease conditions. This study is designed to evaluate cardioprotective potential of ethanol extract of S. arvensis leaves on isoproterenol-induced myocardial infarction in Wistar rat. Male Wistar albino rats were divided into three main groups: negative control (saline only), positive control (isoproterenol only), and S. arvensis extract treated groups. S. arvensis extract was administered in three doses; 50, 100, and 200 mg/kg b.w. p.o for 14 days. On day 13 and 14, isoproterenol (85 mg/kg bw) was given intraperitoneally to positive control and extract treated groups. The parameters studied were cardiac biomarker enzymes which were Creatine Kinase (CK), Creatine Kinase-MB (CK-MB), Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Lactate Dehydrogenase (LDH). The results showed that S. arvensis at dose of 50 mg/kg b.w. could significantly (P<0.05) reduce the level of CK, CK-MB, AST, ALT, and LDH in myocardial infarcted rats compared to positive control. The increase of the dose of S. arvensis extract was not followed by an increase of its cardioprotective activity. In conclusion, Sonchus arvensis L. leaves extract at dose of 50 mg/kg b.w. has potential to be developed as cardioprotective drug.
MALLOW APPS: Aplikasi Berbasis Android untuk Pencegahan dan Monitoring Gangguan Depresi Pratiwi Wikaningtyas; Hubbi Nashrullah Muhammad; Dhyan Kusuma Ayuningtyas; Spoudy Lucianus; Maria Ines Wibowo
Warta Pengabdian Andalas Vol 30 No 3 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.3.451-460.2023

Abstract

Depression is often defined as a mental condition characterized by severe despondency and dejection, typically also with feelings of inadequacy and guilt, often accompanied by a lack of energy and disturbance of appetite and sleep. Its mortality rate is 800 thousand deaths worldwide. This project aims to make a gamified Android-based application to prevent and treat depression titled Mallow apps. The stages of this project were planning, designing, prototyping, usability testing and satisfaction, and publishing. Figma was the primary tool used for designing and prototyping. The prototype’s functionality was measured by success rate and ease of use. User satisfaction was measured by using a SERVQUAL-based questionnaire. Mallow has several features: medication and appointment reminders, drug information, depression self-test, education specifying depression, and a mood board, a collage art therapy. The functionality test showed a success rate of 88.9% and an easiness rating of 4.4 on a scale of one to five in the latest Mallow version. The satisfaction evaluation showed an expectation score of 4.63 and a perception score of 4.42 on a scale from 1 to 5. It is possible to use Mallow Apps for widespread.
Co-Authors Elin Yulinah Sukandar Hubbi Nashrullah Muhammad Maria Ines Wibowo Neng Fisheri Kurniati Pratiwi Wikaningtyas Rian Pardilah Spoudy Lucianus Suliska, Nova