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All Journal Jurnal Akademika Kimia
Sri M. Sabang
Tadulako University
Chemistry Education

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Development of Katuk Leaf Dietary Supplement for Stunting Prevention Using an In Silico Method Wafiq Azizah; Arwansyah Arwansyah; Sri M. Sabang; Sitti Nuryanti; Sitti Rahmawati
Jurnal Akademika Kimia Vol. 15 No. 1 (2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2026.v15.i1.pp32-38

Abstract

Stunting is a chronic nutritional problem caused by long-term malnutrition, resulting in growth disorders in children. This study aims to predict the mechanism of action of secondary metabolites of katuk leaves as an alternative treatment for growth disorders in children (stunting). This research used network pharmacology to predict compounds from katuk leaves (Sauropus androgynus) based on literature studies. Network pharmacology analysis of katuk leaf (Sauropus androgynus) compounds identified 19 proteins, with HSP90AA1 having the highest degree, 14. This study uses molecular docking to predict interactions between active compounds, such as butyrolactone, phenol, and 2,3,4-trimethylpyrrole, and NAD-dependent protein deacetylase sirtuin-1, Aldo-keto reductase family 1 member C3, Carbonic anhydrase 5A, mitochondrial, Cyclin-dependent-like kinase 5, and Glucocorticoid receptor. The molecular docking results show that the butyrolactone compound has the highest binding affinity for 3 proteins, including NAD-dependent protein deacetylase sirtuin-1, with a binding affinity of -4.7 kcal/mol. The phenol compound has 3 proteins with the highest binding affinity, including Aldo-keto reductase family 1 member C3 at -5.5 kcal/mol. And the compound 2,3,4-trimethylpyrrole has 3 proteins with the highest binding affinity values, including the Glucocorticoid receptor, with a value of -5.8 kJ/mol.
Influence Problem-Based Learning Model (PBL) on Student Learning Outcomes on Colloidal Systems Material Nurjanna Nurjanna; Sri M. Sabang; Ijirana Ijirana; Ratman Ratman
Jurnal Akademika Kimia Vol. 15 No. 1 (2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2026.v15.i1.pp46-54

Abstract

Students' chemistry learning outcomes remain relatively low, especially in the colloidal system material, which is considered difficult to understand due to a lack of active student involvement in the learning process. The Problem-Based Learning (PBL) model is an innovative approach that can improve student learning outcomes by presenting real problems that encourage students to think critically, analytically, and actively in finding solutions. This study aims to examine the effect of the PBL model on student learning outcomes in the colloidal system material for class XI at SMA Negeri 1 Palu. The type of research used is a quasi-experiment with a Nonequivalent Control Group Design. The research sample consisted of two classes: class XI-3, the control class, and XI-4, the experimental class, each with 36 students. The research instrument was a multiple-choice learning-outcome test consisting of 15 questions, validated by an expert and found to have 82% validity. Pretest and posttest data were analyzed using the SPSS program version 26.0. The t-test results showed a p-value of 0.043 < 0.05, so H0 was rejected, and H1 was accepted. Thus, it can be concluded that the application of the Problem-Based Learning (PBL) model significantly improves student learning outcomes in colloidal systems. This study provides empirical evidence that the application of PBL can increase active involvement and student learning outcomes, and can serve as a reference for teachers in developing more contextual and student-centered chemistry learning strategies.
Co-Authors Arwansyah Arwansyah Ijirana Nurjanna Nurjanna Ratman Ratman Sitti Nuryanti Sitti Rahmawati Wafiq Azizah