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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Akademika Kimia
Sitti Nuryanti
Tadulako University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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The Effect of Seaweed Soy Tempe Extract on the Reduction of Blood Sugar Levels in Alloxan Induced Rats (Mus musculus) Abdul Hakim Laenggeng; Asriani Hasanuddin; Sitti Nuryanti; Manap Trianto
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11307

Abstract

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia due to impaired insulin secretion or action. This study aimed to examine the antihyperglycemic effect of seaweed soybean tempeh extract in alloxan-induced diabetic mice. A Completely Randomized Design (CRD) was used with 20 healthy male mice (2–3 months old, 25–30 g), divided into five groups: negative control, positive control (metformin), and three treatment groups receiving extract doses of 25, 75, and 125 mg/kg BW. Prior to treatment, mice underwent acclimatization to ensure uniform baseline conditions. Blood glucose levels were measured to assess the effects of the extract. Data were analyzed using ANOVA followed by the Least Significant Difference (LSD) test. The results showed that alloxan effectively induced hyperglycemia by damaging pancreatic beta cells. Administration of seaweed soybean tempeh extract significantly reduced blood glucose levels (p < 0.05). The highest dose (125 mg/kg BW) produced the most notable effect, comparable to metformin, while the 75 mg/kg BW dose also demonstrated significant efficacy. Both were significantly more effective than the lowest dose. In conclusion, seaweed soybean tempeh extract has potential as an alternative antihyperglycemic agent, especially at higher doses.
Development of Katuk Leaf Dietary Supplement for Stunting Prevention Using an In Silico Method Wafiq Azizah; Arwansyah Arwansyah; Sri M. Sabang; Sitti Nuryanti; Sitti Rahmawati
Jurnal Akademika Kimia Vol. 15 No. 1 (2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2026.v15.i1.pp32-38

Abstract

Stunting is a chronic nutritional problem caused by long-term malnutrition, resulting in growth disorders in children. This study aims to predict the mechanism of action of secondary metabolites of katuk leaves as an alternative treatment for growth disorders in children (stunting). This research used network pharmacology to predict compounds from katuk leaves (Sauropus androgynus) based on literature studies. Network pharmacology analysis of katuk leaf (Sauropus androgynus) compounds identified 19 proteins, with HSP90AA1 having the highest degree, 14. This study uses molecular docking to predict interactions between active compounds, such as butyrolactone, phenol, and 2,3,4-trimethylpyrrole, and NAD-dependent protein deacetylase sirtuin-1, Aldo-keto reductase family 1 member C3, Carbonic anhydrase 5A, mitochondrial, Cyclin-dependent-like kinase 5, and Glucocorticoid receptor. The molecular docking results show that the butyrolactone compound has the highest binding affinity for 3 proteins, including NAD-dependent protein deacetylase sirtuin-1, with a binding affinity of -4.7 kcal/mol. The phenol compound has 3 proteins with the highest binding affinity, including Aldo-keto reductase family 1 member C3 at -5.5 kcal/mol. And the compound 2,3,4-trimethylpyrrole has 3 proteins with the highest binding affinity values, including the Glucocorticoid receptor, with a value of -5.8 kJ/mol.
Exploration of Papaya Leaf Bioactive Compounds as Antimalarials Using Network Pharmacology, In Silico, and Learning Resources Giska Ulya; Arwansyah Arwansyah; Sitti Nuryanti; Sitti Rahmawati; Dewi S. Ahmar
Jurnal Akademika Kimia Vol. 15 No. 2 (2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2026.v15.i2.pp77-85

Abstract

Papaya leaves (Carica papaya Linn.) are plants with many benefits due to their active compounds, which can inhibit the growth of malaria parasites. Malaria is an infectious disease caused by the Plasmodium sp. parasite. This study aims to determine the potential of active compounds from papaya leaves (Carica papaya Linn) as an alternative treatment for malaria caused by Plasmodium sp. parasites. This research employs network pharmacology to identify potential protein targets for antimalarial drug development. Also, it employs molecular docking methods to predict the interaction of active compounds such as Carpaine, α,α-Trehalose, Diacylglycerol, N-octanoyl-homoserine lactone, and N-lauroyl glycine with receptors such as Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS), Falcipain, Dipeptidyl Aminopeptidase, Glucose Transporter (PfHT), Peroxiredoxin (Prx), Dihydroorotate Dehydrogenase (DHODH), Plasmepsin, Rhomboid Protease, Phosphoethanolamine N-Methyltransferase (PfPMT), Enoyl-Acyl Carrier Protein Reductase (ENR), and Apical Membrane Antigen 1 (AMA1). Based on the network pharmacology results, 94 protein targets were identified. Molecular docking results for 8 compounds revealed that 5 compounds had potential as antimalarial agents. From these five compounds, five protein targets were selected for each compound based on their high binding affinity. Among the five compounds, Carpaine was identified as having the highest binding affinity with the Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) protein, indicating significant potential for drug development, particularly for malaria prevention. This study also contributes as a scientific learning resource in the fields of chemistry, pharmacy, biotechnology, and health sciences. Therefore, a video-based learning medium was developed and validated in this study, yielding a score of 83.63%, indicating that the learning video is highly suitable as a learning resource.
Co-Authors Abdul Hakim Laenggeng Arwansyah Arwansyah Asriani Hasanuddin Dewi S. Ahmar Giska Ulya Manap Trianto Sitti Rahmawati Sri M. Sabang Wafiq Azizah