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All Journal Jurnal Akademika Kimia
Dewi S. Ahmar
Tadulako University
Chemistry Education

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Exploration of Papaya Leaf Bioactive Compounds as Antimalarials Using Network Pharmacology, In Silico, and Learning Resources Giska Ulya; Arwansyah Arwansyah; Sitti Nuryanti; Sitti Rahmawati; Dewi S. Ahmar
Jurnal Akademika Kimia Vol. 15 No. 2 (2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2026.v15.i2.pp77-85

Abstract

Papaya leaves (Carica papaya Linn.) are plants with many benefits due to their active compounds, which can inhibit the growth of malaria parasites. Malaria is an infectious disease caused by the Plasmodium sp. parasite. This study aims to determine the potential of active compounds from papaya leaves (Carica papaya Linn) as an alternative treatment for malaria caused by Plasmodium sp. parasites. This research employs network pharmacology to identify potential protein targets for antimalarial drug development. Also, it employs molecular docking methods to predict the interaction of active compounds such as Carpaine, α,α-Trehalose, Diacylglycerol, N-octanoyl-homoserine lactone, and N-lauroyl glycine with receptors such as Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS), Falcipain, Dipeptidyl Aminopeptidase, Glucose Transporter (PfHT), Peroxiredoxin (Prx), Dihydroorotate Dehydrogenase (DHODH), Plasmepsin, Rhomboid Protease, Phosphoethanolamine N-Methyltransferase (PfPMT), Enoyl-Acyl Carrier Protein Reductase (ENR), and Apical Membrane Antigen 1 (AMA1). Based on the network pharmacology results, 94 protein targets were identified. Molecular docking results for 8 compounds revealed that 5 compounds had potential as antimalarial agents. From these five compounds, five protein targets were selected for each compound based on their high binding affinity. Among the five compounds, Carpaine was identified as having the highest binding affinity with the Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) protein, indicating significant potential for drug development, particularly for malaria prevention. This study also contributes as a scientific learning resource in the fields of chemistry, pharmacy, biotechnology, and health sciences. Therefore, a video-based learning medium was developed and validated in this study, yielding a score of 83.63%, indicating that the learning video is highly suitable as a learning resource.
Utilization of Purple Trumpet Flower Extract (Ruellia Tuberosa L.) as an Alternative Acid-Base Titration Indicator Sahri Labotano; Teguh Sukriawan; Sitti Aminah; Dewi S. Ahmar; Tri Santoso; Magfirah Magfirah
Jurnal Akademika Kimia Vol. 15 No. 2 (2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2026.v15.i2.pp150-158

Abstract

Anthocyanin-containing plants have potential as environmentally friendly natural acid–base indicators. However, information regarding the suitability of Ruellia tuberosa L. flower extract as a titration indicator remains limited. The aim of this study was to explore the potential of purple trumpet flower extract (Ruellia tuberosa L.) as an alternative acid-base titration indicator. The method used for flower extraction was stepwise maceration with n-hexane, ethyl acetate, and 70% ethanol. The extract was tested for anthocyanin content, color response in buffer solutions at pH 1–14, and performance in strong acid–strong base, weak acid–strong base, and weak base–strong acid titrations. The extract exhibited red at pH 1–3, pink at pH 4–5, colorless at pH 6–8, green at pH 9–12, and yellow at pH 13–14. Endpoint detection was comparable to phenolphthalein and methyl orange, with only slight differences in endpoint pH values. Purple trumpet flower extract shows potential as a natural acid-base indicator and may serve as an alternative for educational and laboratory applications, although further research on stability and quantitative anthocyanin content is still needed.
The Effect of the PBL Model on Literacy and Numeracy Skills in Acid-Base Material Ratman Ratman; Kasmudin Mustapa; Dewi S. Ahmar; Anastasya Anastasya; Ijirana Ijirana; Magfirah Magfirah; Haeruddin Haeruddin
Jurnal Akademika Kimia Vol. 14 No. 3 (2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2025.v14.i3.pp169-173

Abstract

Problem-Based Learning is a learning model that focuses primarily on problems in the learning process. It encourages students to collaborate in groups to solve problems through various activities. The purpose of this study was to determine the effect of the Problem-Based Learning (PBL) model on students' numeracy literacy skills in acid-base material. This study used a quantitative, true-experimental design. The research population consisted of 47 students. The research sample was obtained using purposive sampling, divided into an experimental class of 15 students from class XI MIA 2 and a control class of 16 students from class XI MIA 1. The research instruments included a literacy test comprising 20 multiple-choice questions and a numeracy test comprising five essay questions. Experts validated all instruments provided. Data analysis used the Mann-Whitney test. The results of the data analysis showed that the Mann-Whitney test p-value (0.000) was lower than the predetermined significance level of 0.05. Therefore, it can be concluded that the PBL learning model affects students' numeracy literacy skills.
The Effectiveness of Anti-Mosquito Aromatherapy Candles Formulated with Pine Leaf and Tuberose Flower Essential Oils Febby A. Elvita; Siti Nuryanti; Dewi S. Ahmar; Ijirana Ijirana; Purnama Ningsih
Jurnal Akademika Kimia Vol. 14 No. 4 (2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2025.v14.i4.pp242-250

Abstract

The essential oil of tuberose flowers has a distinctive aroma that mosquitoes dislike and can kill insects, and it also contains eugenol, a beneficial antioxidant. Therefore, this essential oil is utilised in aromatherapy candles. Another essential oil with a distinctive aroma is pine needle oil. Its aroma can relieve cold symptoms and also repel mosquitoes. The objective of this research is to determine the characteristics and effectiveness of essential oil extracts from pine needles (Pinus merkusii) and tuberose flowers (Polianthes tuberosa L) as anti-mosquito aromatherapy candles. The research method used is true experimental. The samples used in this study are pine leaves and tuberose flowers. Fresh pine leaves are steam-distilled, while tuberose essential oil is commercially produced. Then, an evaluation stage of the aromatherapy candle preparation is conducted. The results of the therapeutic effect test on F1 and F4 show a feeling of relaxation and freshness. The percentage of mosquito mortality in formulations F0, F1, F2, F3, and F4 were 0%, 27%, 37%, 43%, and 53% respectively. From these formulations, it can be concluded that F0, F1, F2, and F3 are not effective at killing mosquitoes, as only F4 meets the lethal concentration 50 (LC50) criteria. This shows that in the F4 formulation, the essential oil content, consisting of eugenol and α-pinene, produces the highest mosquito mortality rate, and this combination has the potential to be used as an anti-mosquito aromatherapy wax.
Co-Authors Anastasya Anastasya Arwansyah Arwansyah Febby A. Elvita Giska Ulya Haeruddin Haeruddin Ijirana Kasmudin Mustapa Magfirah Magfirah Purnama Ningsih Ratman Ratman Sahri Labotano Siti Nuryanti Sitti Aminah Sitti Nuryanti Sitti Rahmawati Teguh Sukriawan Tri Santoso