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All Journal Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Delyuzar
Department of Anatomical Pathology, Universitas Sumatera Utara
Humanities Health Professions Medicine & Pharmacology Public Health

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CORRELATION ANALYSIS OF THE HISTOMORPHOLOGICAL SPECTRUM OF TUBERCULOUS GRANULOMATOUS INFLAMMATION WITH ACID-FAST BACILLI DENSITY: ANALISIS KORELASI SPEKTRUM HISTOMORFOLOGI RADANG GRANULOMATOSA TUBERKULOSIS DENGAN KEPADATAN INFILTRASI ACID-FAST BACILLI Delyuzar; Betty; T Kemala Intan; Arie Widiansyah Hasibuan
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 25 No. 2 (2026): Juli 2026
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v25i2.1152

Abstract

The histomorphological spectrum of tuberculous granulomatous inflammation is considered to reflect bacillary replication dynamics and the host immune response. This analytic observational cross-sectional study was conducted retrospectively by reviewing secondary medical records and archived histopathology slides and paraffin blocks to assess the correlation and strength of association between tuberculous granulomatous histomorphology on Hematoxylin–Eosin staining and acid-fast bacilli (AFB) density on Modified Ziehl–Neelsen staining at the Unit Patologi Anatomik Rumah Sakit Pendidikan Prof. dr. Chairuddin Panusunan Lubis USU Medan and Rumah Sakit Columbia Asia Medan during 2023–2025, using consecutive sampling; 68 cases met the inclusion criteria. Histomorphology was categorized into epithelioid granuloma with or without Langhans-type giant cells with a necrotic mass, epithelioid granuloma with or without Langhans-type giant cells without necrosis, and acellular eosinophilic mass with inflammatory cells. AFB density was graded semi-quantitatively (0, +1, +2, +3) at 1000× magnification. Statistical analysis was performed using Fisher-Freeman-Halton exact test and Cramer’s V. Most cases were extrapulmonary (95.59%), demonstrated epithelioid granuloma with necrosis (69.12%), and showed an AFB score of +1 (67.65%). Histomorphology showed a significant correlation with AFB density (p<0.001) with a strong association (Cramer’s V=0.59), whereas correlations with organ group, age, and sex were not significant (p>0.05).
Co-Authors Arie Widiansyah Hasibuan Betty T Kemala Intan