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All Journal Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Arie Widiansyah Hasibuan
Department of Anatomical Pathology, Universitas Sumatera Utara
Humanities Health Professions Medicine & Pharmacology Public Health

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CORRELATION ANALYSIS OF THE HISTOMORPHOLOGICAL SPECTRUM OF TUBERCULOUS GRANULOMATOUS INFLAMMATION WITH ACID-FAST BACILLI DENSITY: ANALISIS KORELASI SPEKTRUM HISTOMORFOLOGI RADANG GRANULOMATOSA TUBERKULOSIS DENGAN KEPADATAN INFILTRASI ACID-FAST BACILLI Delyuzar; Betty; T Kemala Intan; Arie Widiansyah Hasibuan
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 25 No. 2 (2026): Juli 2026
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v25i2.1152

Abstract

The histomorphological spectrum of tuberculous granulomatous inflammation is considered to reflect bacillary replication dynamics and the host immune response. This analytic observational cross-sectional study was conducted retrospectively by reviewing secondary medical records and archived histopathology slides and paraffin blocks to assess the correlation and strength of association between tuberculous granulomatous histomorphology on Hematoxylin–Eosin staining and acid-fast bacilli (AFB) density on Modified Ziehl–Neelsen staining at the Unit Patologi Anatomik Rumah Sakit Pendidikan Prof. dr. Chairuddin Panusunan Lubis USU Medan and Rumah Sakit Columbia Asia Medan during 2023–2025, using consecutive sampling; 68 cases met the inclusion criteria. Histomorphology was categorized into epithelioid granuloma with or without Langhans-type giant cells with a necrotic mass, epithelioid granuloma with or without Langhans-type giant cells without necrosis, and acellular eosinophilic mass with inflammatory cells. AFB density was graded semi-quantitatively (0, +1, +2, +3) at 1000× magnification. Statistical analysis was performed using Fisher-Freeman-Halton exact test and Cramer’s V. Most cases were extrapulmonary (95.59%), demonstrated epithelioid granuloma with necrosis (69.12%), and showed an AFB score of +1 (67.65%). Histomorphology showed a significant correlation with AFB density (p<0.001) with a strong association (Cramer’s V=0.59), whereas correlations with organ group, age, and sex were not significant (p>0.05).
CLINICOHISTOPATHOLOGICAL CHARACTERISTICS OF PROSTATE LESIONS AT RUMAH SAKIT PENDIDIKAN PROF. DR. CHAIRUDDIN PANUSUNAN LUBIS MEDAN, 2023-2024: KARAKTERISTIK KLINIKOHISTOPATOLOGI LESI PROSTAT DI RUMAH SAKIT PENDIDIKAN PROF. DR. CHAIRUDDIN PANUSUNAN LUBIS MEDAN, 2023–2024 Lidya Imelda Laksmi; Causa Trisna Mariedina; Betty; Joko S Lukitoa; Arie Widiansyah Hasibuan
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 26 No. 1 (2027): Januari 2027
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v26i1.1355

Abstract

Prostatic enlargement is a global health problem among older men, caused by non-neoplastic or neoplastic lesions and commonly presenting as lower urinary tract symptoms. Benign Prostatic Hyperplasia (BPH) is the leading non-neoplastic etiology, whereas Acinar Prostatic Carcinoma (APC) is the most common malignant neoplasm. High-Grade Prostatic Intraepithelial Neoplasia (HGPIN), a precursor lesion, and Atypical Small Acinar Proliferation (ASAP), a suspicious atypical acinar proliferation, are critical differential diagnoses and pitfalls influencing management and prognosis. Using total sampling, this retrospective cross-sectional study characterized clinicohistopathological features of prostatic lesions in patients undergoing prostate core needle biopsy and/or transurethral resection of the prostate at Rumah Sakit Pendidikan Prof. dr. Chairuddin Panusunan Lubis Medan, from January 2023 to June 2024. Histopathological evaluation used hematoxylin and eosin staining. Forty-three specimens were analyzed descriptively: 33 (76.74%) were BPH and 10 (23.26%) were APC; neither ASAP nor HGPIN was identified. Benign and malignant lesions occurred most frequently among patients aged 60–69 years; the youngest were aged 50–59 years. Ultrasonographic diagnoses agreed with histopathology in 83.33% of BPH cases and 66.67% of APC cases. BPH specimens predominantly showed papillary infolding and cystic atrophy, corpora amylacea as the principal intraluminal secretion, and squamous metaplasia as a distinctive finding. APC specimens predominantly showed tufting, cribriform, and micropapillary architectures; blue mucin and crystalloids as intraluminal secretions; and signet-ring cell morphology as a distinctive finding. Benign lesions showed papillary infolding and cystic atrophy, with intraluminal corpora amylacea. Malignant lesions showed tufting, cribriform and micropapillary patterns, with intraluminal blue mucin and crystalloids.
Co-Authors Betty Causa Trisna Mariedina Delyuzar Joko S Lukitoa Lidya Imelda Laksmi T Kemala Intan