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All Journal Hydrogen: Jurnal Kependidikan Kimia
Fakhrotun Nisa
Chemistry Department, Faculty of Mathematics and Natural Science, Universitas Pamulang, Jl. Suryakencana No. 1, Tangerang Selatan, Indonesia
Chemistry Education

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In Vitro Evaluation of the Anti-Diabetic Potential of Oxovanadium(IV) Complex with Terpyridine Ligand Fakhrotun Nisa; Djulia Onggo
Hydrogen: Jurnal Kependidikan Kimia Vol. 14 No. 2 (2026): April 2026
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v14i2.20322

Abstract

An oxovanadium(IV) complex with 2,2′:6′,2″-terpyridine ligand, [VO(terpy)]SO₄, was synthesized and characterized to evaluate its anti-diabetic potential. The complex was synthesized via a direct reaction between VOSO₄ as the metal source and terpyridine ligand in solution and confirmed through conductometric and mass spectrometric analyses. Conductivity measurements indicated that the complex behaves as a 2:2 electrolyte in aqueous solution, dissociating into [VO(terpy)]²⁺ and SO₄²⁻ ions. Mass spectrometry revealed a peak at m/z 150.0098 corresponding to the cationic species. The anti-diabetic activity was evaluated through in vivo studies using alloxan-induced diabetic rats, demonstrating a significant reduction in fasting blood glucose levels. These findings suggest that the oxovanadium(IV)–terpyridine complex is a candidate for further development as an anti-diabetic agent.
Co-Authors Djulia Onggo