Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Riset Kefarmasian Indonesia
Pande Made Desy Ratnasari
Universitas Pendidikan Nasional
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Adverse Drug Reactions to Antituberculosis Drugs in Tuberculosis Patients Using the Naranjo Algorithm at a Regional Hospital in Mataram Recta Olivia Umboro; Fitri Apriliany; Pande Made Desy Ratnasari; Anita Mursiany
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.975

Abstract

Tuberculosis (TB) remains one of the major health problems in Indonesia. As of October 2023, 67,770 TB cases were reported in West Nusa Tenggara Province (NTB). TB treatment requires long-term therapy using combinations of antituberculosis drugs (ATBD), which have the potential to cause Adverse Drug Reactions (ADRs). ADRs that are not properly identified and managed can increase morbidity and mortality in TB patients and negatively affect treatment outcomes.This study aimed to determine the incidence of ADRs related to the use of ATBD in TB patients at Mataram City Regional General Hospital, NTB, from February to June 2023. This observational study employed a cross-sectional design. Data were collected through structured interviews, and the Naranjo Algorithm was used to assess the causality between reported symptoms and drug use. A total of 66 patients were included in the study. The most common definite ADRs was associated with rifampicin, characterized by reddish discoloration of urine (45.70%), followed by isoniazid-induced fatigue (34%). Probable ADRs were observed with streptomycin, isoniazid, rifampicin, and pyrazinamide, mainly presenting as itching or skin rash (11.10%). Possible ADRs included headache (4.90%) and pain (4.30%), predominantly related to rifampicin use. In conclusion, ADRs among TB patients receiving ATBD at Mataram City Regional General Hospital were diverse, with rifampicin-related urine discoloration being the most prevalent. Identification of ADRs using the Naranjo Algorithm is important for early intervention, improving treatment success, and preventing drug resistance.
Analysis of the Relationship Between Providing Drug Information, Medication Adherence, and Glycemic Control in Type 2 Diabetes Outpatients at the North Denpasar Health Center Pande Made Desy Ratnasari; Agustina Nila Yuliawati; Anak Agung Ngurah Putra Riana Prasetya; Ni Luh Koming Krisnamahesswari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009708

Abstract

Medication adherence among patients with type 2 diabetes mellitus (T2DM) continues to be a difficult challenge. Providing drug information (PDI) at health centers can enhance medication adherence and help patients achieve glycemic control. A cross-sectional study was conducted in February-April 2024 at the North Denpasar Health Center. Inclusion criteria were patients 18 years old either with or without comorbidities, receiving the same antidiabetic treatment for ≥3 months. Exclusion criteria were patients who withdrew from the study, changed their care, or had unstable health conditions. Medication adherence data were collected using the Probabilistic Medication Adherence Scale (ProMAS) questionnaire, PDI data and fasting blood glucose (FBS) examination results in medical records using data collection documents. Correlation analysis between PDI and medication adherence and glycemic control used the Kendall's tau-b/c test. Results showed patients were mostly male (53.84%), age ≥65 (43.20%), elementary school education (35.50%), unemployed (63.90%), no family history (70.41%), disease duration 5 years (62.72%), with comorbidities (65.09%), and FBS achieved (81.66%). The antidiabetic used was a combination of metformin and glimepiride (54.43%). A total of 81.65% obtained routine PDI with high medication adherence (48.52%). The conclusion of the study was that there was a significant relationship between PDI with medication adherence (p=0.000; r=0.253) and glycemic control (p=0.000; r=0.447).
Co-Authors Agustina Nila Yuliawati Anak Agung Ngurah Putra Riana Prasetya Anita Mursiany Fitri Apriliany, Fitri Ni Luh Koming Krisnamahesswari Umboro, Recta Olivia