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All Journal Vitek : Bidang Kedokteran Hewan
Lita Rakhma Yustinasari
Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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In Silico Evaluation of Physalis angulata Secondary Metabolites as Potential QcrB Inhibitors in Mycobacterium tuberculosis and Mycobacterium bovis  Zahir Thoriq -; Lia Puspitasari; Lita Rakhma Yustinasari; Suryo Kuncorojakti; Tarshan Sharma Suresh
VITEK : Bidang Kedokteran Hewan Vol. 16 No. 1 (2026): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/b51bvx32

Abstract

Antimicrobial resistance in Mycobacterium tuberculosis and Mycobacterium bovis remains a major challenge in human and veterinary medicine, emphasizing the importance of identifying novel therapeutic compounds. This study aimed to predict the most promising secondary metabolite of Physalis angulata as a quinol–cytochrome c reductase subunit B (QcrB) inhibitor using an in silico approach. Sequence alignment of QcrB proteins from M. tuberculosis and M. bovis demonstrated complete sequence identity, indicating that compounds targeting QcrB in M. tuberculosis may exhibit comparable binding behavior toward QcrB in M. bovis. Among 51 identified metabolites, nine satisfied drug-likeness and safety criteria and underwent molecular docking analysis. Docking simulations predicted that four metabolites occupied the QcrB binding pocket, with withaphysanolide A exhibiting the most favorable interaction profile based on predicted binding free energy and correspondence with reference residues. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis predicted favorable pharmacokinetic and safety-related characteristics for withaphysanolide A. However, these findings should be interpreted in light of several limitations, including the use of rigid docking and the absence of molecular dynamics simulations. Collectively, the results suggest that withaphysanolide A may represent a promising QcrB inhibitor candidate for further investigation, although in vitro and in vivo validation remains necessary.
A comperhensive review: Antimicrobial Resistance in Indonesia One Health Challenge Ranto Bayu Damanik; Alfiana Laili Dwi Agustin; Agus Widodo; Eka Pramyrtha Hestianah; Danti Nur Indiastuti; Ratna Damayanti; Kuncoro Puguh Santoso; Boedi Setiawan; Rahmi Sugihartuti; Vivi Oktaviana; Rury Mega Wahyuni; Lita Rakhma Yustinasari
VITEK : Bidang Kedokteran Hewan Vol. 16 No. 1 (2026): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/3svevz51

Abstract

Antimicrobial resistance has become a major global health concern affecting humans, animals, and the environment. The increasing occurrence of antibiotic resistant bacteria threatens the effectiveness of antimicrobial therapy and poses serious public health risks. This review aims to describe the occurrence and distribution of antimicrobial resistant Escherichia coli across humans, animals, wildlife, and environmental sources using a One Health perspective. A literature review approach was conducted by collecting scientific articles published between 2015 and 2025 from international and national databases including PubMed, Scopus, and Google Scholar. Articles were selected based on relevance to antimicrobial resistance in Escherichia coli within human, animal, and environmental contexts. The reviewed studies indicate that Escherichia coli isolates frequently show resistance to commonly used antibiotics such as ampicillin, tetracycline, fluoroquinolones, and third generation cephalosporins. Multidrug resistant strains and extended spectrum beta lactamase producing bacteria have been reported in clinical samples, livestock, companion animals, wildlife, and environmental samples including wastewater and river water. These findings highlight the interconnected nature of antimicrobial resistance transmission between humans, animals, and the environment. Integrated surveillance and responsible antibiotic use are essential to control the spread of antimicrobial resistance through the One Health approach
Co-Authors Agus Widodo Alfiana Laili Dwi Agustin Boedi Setiawan Eka Pramyrtha Hestianah Indiastuti, Danti Nur Kuncoro Puguh Santoso Lia Puspitasari Rahmi Sugihartuti Ranto Bayu Damanik Ratna Damayanti Rury Mega Wahyuni Suryo Kuncorojakti Tarshan Sharma Suresh Vivi Oktaviana Zahir Thoriq -