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All Journal Journal of Educational Innovation and Public Health
Naswa Salsabila
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Formulasi dan Evaluasi Sediaan Body Lotion Ekstrak Etanol Kulit Jeruk Manis (Citrus x aurantium L.) Embun Larasati Kuncoro; Naswa Salsabila; Margaret Rianti Martalina; Renata Amalia Azizah; Zefanya Yoga Permana Purba
Journal of Educational Innovation and Public Health Vol. 4 No. 2 (2026): April: Journal of Educational Innovation and Public Health
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i2.9110

Abstract

Sweet orange peel (Citrus x aurantium L.) is an agricultural by-product rich in bioactive compounds including flavonoids, phenolics, terpenoids, and vitamin C with antioxidant and moisturizing potential. This study aimed to formulate and evaluate a body lotion using 15% ethanol extract of sweet orange peel obtained by maceration with 96% ethanol. Evaluations included organoleptic, homogeneity, pH, adhesion, spreadability, viscosity, irritation, cycling test, cream type, and DPPH antioxidant activity assessments. The preparation was semisolid, yellow, with a characteristic herbal aroma, homogeneous, pH 8, adhesion time of 4.10 seconds, spreadability of 9.9–11.1 cm, and acceptable viscosity. The preparation caused no skin irritation, remained stable through six cycling test cycles, and formed an oil-in-water (O/W) emulsion. Antioxidant activity showed an IC₅₀ of 284.6 ppm (weak category) compared to vitamin C as positive control (IC₅₀ 4.2 ppm). It was concluded that ethanol extract of sweet orange peel can be formulated into a stable and safe body lotion, though further optimization is needed to enhance its antioxidant activity.
Formulasi dan Evaluasi Sediaan Suppositoria Ibuprofen Naswa Salsabila; Lubna Nurul Mumtazah; Sayna Wahyu Ananta; Adriansyah Adriansyah; Zahra Alatas
Journal of Educational Innovation and Public Health Vol. 4 No. 2 (2026): April: Journal of Educational Innovation and Public Health
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i2.9121

Abstract

Ibuprofen is an antipyretic and anti-inflammatory drug classified as Biopharmaceutics Classification System (BCS) class II, characterized by low water solubility and high permeability. Its limited solubility may reduce the dissolution rate and influence therapeutic effectiveness. This study aimed to formulate ibuprofen suppositories using cocoa butter (oleum cacao) as the suppository base through the melting method. Each suppository was prepared with a total weight of 2500 mg containing 125 mg ibuprofen, oleum cacao as the base, tween 80 as an emulsifier, and liquid paraffin as a mold lubricant. Before formulation, a displacement value test was performed to determine the exact amount of base required. The prepared suppositories were evaluated through organoleptic examination, weight uniformity, melting time, and dissolution testing. The evaluation results demonstrated that the suppositories possessed acceptable physical characteristics, uniform weight distribution, appropriate melting properties, and satisfactory dissolution behavior. Based on these findings, ibuprofen suppositories formulated with oleum cacao fulfilled pharmaceutical quality requirements in accordance with the Indonesian Pharmacopoeia standards.
Co-Authors Adriansyah Adriansyah Embun Larasati Kuncoro Lubna Nurul Mumtazah Margaret Rianti Martalina Renata Amalia Azizah Sayna Wahyu Ananta Zahra Alatas Zefanya Yoga Permana Purba