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All Journal Jurnal Ners Advance Sustainable Science, Engineering and Technology (ASSET)
Felanda Ahsanu Nadia
Universitas Sumatera Utara
Chemistry Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing

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Exploring Serum Bilirubin as a Potential Biomarker for Primary Open-Angle Glaucoma Delfi; Masitha Dewi Sari; Felanda Ahsanu Nadia
Advance Sustainable Science Engineering and Technology Vol. 8 No. 3 (2026): May - July
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v8i3.2383

Abstract

Total bilirubin (TBIL) functions as a natural antioxidant, and its levels tend to decrease with increasing oxidative stress, including in glaucoma tissue. This study aims to explore the relationship between total serum bilirubin levels and the severity of primary open-angle glaucoma (POAG). A total of 25 POAG patients and 25 control subjects further divided into aged >60 years and ≤60 years from the Glaucoma Clinic of the Universitas Sumatera Utara Hospital and its affiliated hospitals were included, consisting of 4 patients with moderate disease and 21 with advanced disease. Serum TBIL levels were measured and analyzed using the Mann-Whitney test. Results showed an average TBIL of 0.23 mg/dL in moderate cases and 0.37 mg/dL in advanced cases, with no significant relationship between TBIL and POAG severity (p=0.131). These findings indicate that total serum bilirubin levels are not related to POAG severity and are likely not a reliable clinical biomarker for glaucoma.
Hubungan Kadar Serum Total Bilirubin Dengan Kejadian Glaukoma Pada Penderita Glaukoma Sudut Terbuka Primer Delfi Delfi; Felanda Ahsanu Nadia; Masitha Dewi Sari
Jurnal Ners Vol. 10 No. 4 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.62474

Abstract

Latar Belakang: Primary Open-Angle Glaucoma (POAG) merupakan penyakit multifaktorial yang menjadi penyebab utama kebutaan permanen. Total bilirubin (TBIL) sebagai antioksidan endogen berbanding terbalik dengan stres oksidatif yang diduga berperan pada patogenesis glaukoma. Tujuan: Mengetahui hubungan kadar serum total bilirubin dengan kejadian glaukoma pada penderita POAG di RS Universitas Sumatera Utara dan RS Jejaring. Metode: Penelitian analitik observasional dengan desain cross-sectional, melibatkan 25 subyek POAG dan 25 subyek kontrol di Poli Penyakit Mata Divisi Glaukoma RS USU dan RS Jejaring periode November 2023–Maret 2024. Kanndar serum total bilirubin diperiksa dengan Cobas 6000. Analisis menggunakan uji T-Independent, Mann-Whitney, dan Kruskal-Wallis (α=5%). Hasil: Rerata kadar bilirubin total pada kelompok POAG 0,36 mg/dL (SD 0,15) dan kontrol 0,40 mg/dL (SD 0,18), tanpa perbedaan bermakna (p=0,503; Mann-Whitney). Rerata pada POAG medium 0,25 mg/dL dan advance 0,38 mg/dL, tanpa hubungan bermakna (p=0,110). Tidak terdapat hubungan bermakna antara kadar bilirubin total dengan derajat POAG berdasarkan jenis kelamin perempuan (p=0,150), usia >60 tahun (p=0,131), maupun riwayat keluarga POAG (p=0,097 dan p=0,545). Kesimpulan: Tidak terdapat hubungan antara kadar serum total bilirubin dengan kejadian glaukoma pada penderita POAG.
Co-Authors Delfi Delfi Delfi Masitha Dewi Sari