<![CDATA[The JAK/STAT (Janus kinase/signal transducer and activator of transcription) signaling cascade constitutes an intracellular communication framework that is responsive to cytokines and growth factors, whereas the MAPK (Mitogen-activated protein kinase) pathway represents a signaling network activated by extrinsic stimuli such as stress, growth factors, or reactive oxygen species. This literature review synthesizes scholarly investigations concerning the roles of the JAK/STAT and MAPK signaling pathways in the progression of chronic obstructive pulmonary disease (COPD), with an emphasis on elucidating the molecular interactions and mechanisms to rectify deficiencies in the comprehension of their contributions to inflammation, immune modulation, and tissue remodeling. The objectives of this review were to assess pathway activation patterns, characterize the molecular structures, and compare the therapeutic strategies. A systematic analysis of multidisciplinary studies employing in vitro, in vivo, clinical, and bioinformatics approaches was conducted. The findings revealed consistent activation of STAT3 and p38 MAPK isoforms by cigarette smoke and inflammatory stimuli, with complex crosstalk shaping macrophage polarization and cytokine production (IL-6, TNF-α). Therapeutic interventions targeting JAK/STAT and MAPK signaling have the potential to reduce airway inflammation and remodeling, although clinical efficacy remains inconsistent due to corticosteroid resistance and activation of compensatory pathway. Pathway dysregulation correlates with accelerated COPD progression, particularly through epithelial–mesenchymal transition and extracellular matrix deposition. Key challenges include balancing pathway modulation to preserve lung homeostasis while avoiding immunosuppressive effects. This analysis highlights the need for precision targeting strategies to translate molecular insights into effective therapies, thus providing a framework for future research on COPD pathogenesis and targeted network modulation.]]>
